Optical sensor for monitoring the partial pressure of oxygen

• US 4,752,115 A
• Filed: 02/07/1985
• Issued: 06/21/1988
• Est. Priority Date: 02/07/1985
• Status: Expired due to Term

• Current Assignee: Becton Dickinson Critical Care Systems Pte Ltd. (Becton, Dickinson & Co)
• Original Assignee: Spectramed, Inc.
• Inventors: Lefkowitz, Steven M., Murray, Richard C. Jr.
• Primary Examiner(s): LaRoche, Eugene R.
• Assistant Examiner(s): Mottola, Steven J.
• Application Number:
  US06/699,515
• Time in Patent Office: 1,230 Days
• Field of Search: 250/357.1, 250/361 C, 250/361 R, 250/362, 250/458.1, 250/459.1, 250/483.1, 250/484.1, 250/485.1, 250/486.1, 250/487.1, 350/96.29, 350/96.30, 350/96.31, 350/96.33, 350/96.34, 356/41
• US Class Current: 385/12
• CPC Class Codes: C09K 11/06 containing organic luminescent materials
• CPC Class Codes: G01N 2021/6432 Quenching
• CPC Class Codes: G01N 2021/7786 Fluorescence
• CPC Class Codes: G01N 21/6428 Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" in vivo A61B5/00; immunoassay G01N33/53
• CPC Class Codes: G01N 21/7703 using reagent-clad optical fibres or optical waveguides using measurement of total internal reflection or attenuated total reflection G01N21/552; optical fibres or waveguides per se G02B

Abstract

A device is described for sensing oxygen, particularly for use in medical applications. The device includes an optical waveguide and an oxygen sensing medium disposed on the waveguide. The sensing medium fluoresces in response to light from a light source such that the intensity of fluorescence is dependent on the partial pressure of oxygen in the environment. The sensing medium includes an oxygen sensitive fluorescent dye in a matrix consisting of a plasticized polymer.

Claims

1. A device for monitoring oxygen in an environmental in response to light transmitted from a light source comprising:

an optical waveguide to receive light transmitted from the light source; and

a coating of oxygen-sensitive medium disposed on said waveguide wherein said sensitive medium fluoresces in response to light from said light source, the intensity of fluorescence of said sensitive medium being dependent on the partial pressure of oxygen present in the environment being monitored, said sensitive-medium including an inorganic oxygen-sensitive fluorescent dye in a plasticized polymer matrix.

2. A device for monitoring oxygen as recited in claim 1, wherein:

said plasticized polymer includes at least twenty-five percent plasticizer.

3. A device for monitoring oxygen as recited in claim 2, wherein:

said oxygen-sensitive fluorescent dye includes tris (4,7-diphenyl-1,10-phenanthroline) Ru(II) perchlorate.

4. A device for monitoring oxygen as recited in claim 2, wherein:

said oxygen-sensitive fluorescent dye is formed of any oxygen-responsive fluorescent salt of tris (4,7-diphenyl-1,10-phenanthroline) Ru(II) cation.

5. A device for monitoring oxygen as recited in claim 2, wherein:

said oxygen-sensitive fluorescent dye is made of any oxygen-responsive, fluorescent salt of a transition metal complex having as a ligand a derivative of 1,10-phenanthroline.

6. A device for monitoring oxygen as recited in claim 2, wherein:

said oxygen-sensitive fluorescent dye is made of any oxygen-responsive, fluorescent salt of a transition metal complex having as a ligand 1,10-phenanthroline.

7. A device for monitoring oxygen as recited in claim 5, wherein:

said transition-metal complex is selected from the group consisting of ruthenium (II), osmium (II), rhodium (III) and iridium (III).

8. A device for monitoring oxygen as recited in claim 2, wherein:

said plasticized polymer is formed of polyvinyl chloride plasticized with didecyl phthalate.

9. A device for monitoring oxygen as recited in claim 8, wherein:

said plasticized polymer includes fifty weight percent of didecyl phthalate.

10. A device for monitoring oxygen as recited in claim 2, wherein:

said plasticized polymer is plasticized with a derivative of phthalic acid, said derivative being compatible with said polymer.

11. A device for monitoring oxygen as recited in claim 2, wherein:

said plasticized polymer includes a plasticizer selected from the group of materials consisting of phthalic acid derivatives, citric acid derivatives, adipic acid derivatives, and sebacic acid derivatives.

12. A device for monitoring oxygen as recited in claim 2, wherein:

said plasticized polymer includes a polymer selected from the group of materials consisting of polyvinyl chloride, polystyrene, polyurethane, polyvinyl butyral, polymethyl methacrylate and silicone rubber.

13. A device for monitoring oxygen as recited in claim 1, wherein:

said waveguide is a fiber optic waveguide having a core surrounded by a cladding, a portion of said cladding being removed from said waveguide to expose a portion of said core, said oxygen sensing medium being disposed on said exposed core.

14. A device for monitoring oxygen as recited in claim 1, wherein:

said waveguide is a fiber-optic waveguide having first and second ends, said oxygen-sensing medium being disposed on said first end of said waveguide, said light source being disposed at said second end of said waveguide.

15. A device for monitoring oxygen as recited in claim 1, wherein:

said waveguide is a fiber-optic waveguide having a core surrounded by a cladding and having first and second ends, said light source being disposed at said second end of said waveguide, said first end of said waveguide terminating in an acute angle exposing an elongated portion of said core, said oxygen sensing medium being disposed on said elongated portion of said core.

16. A device for monitoring oxygen as recited in claim 15, wherein:

said acute angle is less than about sixty degrees.

17. A device for monitoring oxygen as recited in claim 15, wherein:

said angle is between about twenty and about thirty degrees.

18. A device as recited in claim 1, further comprising:

a sleeve surrounding said waveguide, said sleeve being formed of a gas-permeable, solution-impermeable membrane.

19. A device for monitoring oxygen as comprising:

an acrylic optical fiber, having a generally cylindrical core surrounded by a cladding, said fiber having first and second ends, said first end terminating in an acute angle of between about twenty degrees and about thirty degrees to expose an elongated portion of said core; and

an oxygen-sensing medium composed of tris (4,7-diphenyl-1,10-phenanthroline) (RuII) perchlorate dye in a matrix of polyvinyl chloride and didecyl phthalate, said matrix consisting of fifty-weight-percent didecyl phthalate, said matrix being saturated with said dye, said oxygen sensing medium being disposed on said exposed portion of said core.

20. A device as recited in claim 19, further comprising:

a gas permeable, solution impermeable membrane disposed about said fiber and said sensing medium.

21. A method for forming an oxygen sensor comprising the steps of:

immersing an elongated portion of an exposed optical fiber core in an oxygen sensing medium dissolved in a volatile solvent, said solvent being unable to dissolve said fiber, and said elongated portion terminating in an acute angle of less than about sixty degrees; and

allowing said solvent to evaporate to cause said oxygen sensing medium to dry to a solid phase.

22. A method for forming an oxygen sensor as recited in claim 21 further comprising the step of:

forming a gas-permeable, solution-impermeable membrane about said fiber and said sensing medium.

23. A device for monitoring oxygen in an environment in response to light transmitted from a light source comprising:

a fiber-optic waveguide having a core surrounded by a cladding and having first and second ends, said light source being disposed at said second end of said waveguide, said first end of said waveguide terminating in an acute angle exposing an elongated portion of said core, said oxygen sensing medium being disposed on said elongated portion of said core.

24. A device for monitoring oxygen as recited in claim 23, wherein:

said acute angle is less than about sixty degrees.

25. A device for monitoring oxygen as recited in claim 23, wherein:

said angle is between about twenty degrees and about thirty degrees.