Method of treating pain with urea and glyoxal compositions

• US 4,752,620 A
• Filed: 11/21/1986
• Issued: 06/21/1988
• Est. Priority Date: 11/21/1986
• Status: Expired due to Term

• Current Assignee: David Roberts
• Original Assignee: David Roberts
• Inventors: Roberts, David
• Primary Examiner(s): FRIEDMAN, STANLEY
• Application Number:
  US06/934,243
• Time in Patent Office: 578 Days
• Field of Search: 514/588, 514/693
• US Class Current: 514/588
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/11 Aldehydes
• CPC Class Codes: A61K 31/17 having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine isoureas, isothioureas A61K31/155; sulfonylureas A61K31/64

Abstract

A method of alleviating or "breaking" pain caused by contusions to the skin using a composition containing glyoxal, urea and an inert carrier.

Claims

1. A method for relieving pain, in a mammal, from body contusions which comprises topically applying to the skin of said mammal, an effective amount of an analgesic composition comprising:

a. from about 0.08 to about 4 percent by weight of glyoxal;

b. from about 0.04 to about 8 percent by weight of urea; and

c. as an inert carrier, water, a lower alkanol, or a mixture of water and lower alkanol,

whereby said skin is substantially instaneously relieved of pain.

2. A method according to claim 1 wherein said composition also includes from about 0.1 to about 4 percent of benzyl alcohol.

3. A method according to claim 1 wherein said composition also includes from about 0.1 to about 4 percent of diethylene glycol monoethyl ether.

4. A method according to claim 1 wherein said composition also includes:

d. from about 0.1 to about 4 percent by weight of benzyl alcohol; and

e. from about 0.1 to about 4 percent by weight of diethylene glycol monoethyl ether.

6. A method of relieving pain from body contusions comprising applying to the skin of a composition as defined in claim 4.

5. A method for relieving pain, in a mammal, from body contusions which comprises topically applying to the skin of said mammal, an effective amount of an analgesic composition comprising (a) an analgesic effective amount of glycoxal, (b) an analgesic effective amount of urea;

and (c) an inert carrier selectd from the group consisting of water, a lower alkanol and mixtures thereof.