Self-driven pump

• US 4,753,651 A
• Filed: 08/30/1982
• Issued: 06/28/1988
• Est. Priority Date: 08/30/1982
• Status: Expired due to Fees

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Eckenhoff, James B.
• Primary Examiner(s): NOT, DEFINED
• Assistant Examiner(s): Macey, H.
• Application Number:
  US06/412,465
• Time in Patent Office: 2,129 Days
• Field of Search: 604/896, 604/890, 604/891, 604/892, 604/51-53, 604/93, 604/31, 604/150, 604/151
• US Class Current: 424/449
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/145 using pressurised reservoirs, e.g. pressurised by means of pistons

Abstract

A self-driven pump that delivers a flowable composition at a constant baseline rate and may be manipulated to supplement the baseline rate with one or more pulses of the composition. One pump embodiment consists of a rigid hollow housing with one fixed end wall and one axially moveable end wall; an axially slideable water imbibing assembly mounted transversely in the housing lumen that divides the lumen into a first compartment containing the composition to be dispersed and a second liquid to be imbibed, preferably water, containing compartment. An outlet port extends through the wall of the housing into the first compartment. In operation the subassembly imbibes water from the second compartment and expands into the first compartment to displace the composition therefrom through the outlet at the baseline rate. Pulses are effected by depressing the axially moveable end wall which in turn slides the subassembly toward the fixed end wall thereby exerting pressure on the composition to be dispersed and increasing the injection rate.

Claims

1. A self-driven pump for dispensing a fluid composition comprising

(a) a hollow closed rigid body;

(b) a liquid imbibing member mounted within the body that divides the lumen of the body into a first compartment adapted to hold the fluid to be dispensed and a second compartment adapted to hold the liquid to be imbibed, the liquid imbibing member comprising;

(i) a rigid semipermeable wall that faces the second compartment;

(ii) an expandable impermeable wall that faces the first compartment; and

(iii) a liquid imbibing composition contained between the rigid semipermeable wall and the expandable impermeable wall; and

(c) outlet means extending through the wall of the body, in fluid communication with said first compartment.

2. The pump of claim 1 wherein the liquid imbibing member is mounted within the body such that the member is not capable of movement other than the expansion of said expandable impermeable wall.

3. The pump of claim 1 wherein the liquid imbibing member is able to slide toward the first compartment and the injector includes:

(d) manually operable means for exerting a force on the member to cause it to slide within the body toward the first compartment.

15. The pump of claims 1 or 4 including (d) manually operable means for exerting pressure on the composition to be dispensed.

16. The pump of claim 15 wherein the means is an opening through the wall of the body to the first compartment and a piston that fits into the opening.

17. The pump of claims 1, 2, 3, 4, 5, 6, 7, 8, 12, 13, 14, 6, 7, 8, or 16 wherein said liquid to be imbibed is water.

18. The pump of claim 15 wherein said means for exerting pressure on the composition to be dispensed comprise fluid transmitting means extending through said wall providing fluid communication between the interior of said first compartment and externally operated pressure generating means.

19. The pump of claim 15 wherein the outlet means is in fluid communication with the interior of a live animal.

20. The pump of claims 1 or 4 wherein said outlet means is in fluid communication with the interior of the body of a live animal.

4. A self-driven pump for dispensing a fluid composition comprising:

(a) a rigid hollow housing having a cylindrical lumen, said housing being provided with means for closing the ends of the housing;

(b) a liquid imbibing member mounted transversely within the housing that divides the lumen of the housing into a first compartment that contains the fluid composition and a second compartment that contains the liquid to be imbibed, the liquid imbibing member comprising

(i) a rigid semipermeable wall that faces the second compartment;

(ii) an expandable impermeable wall that faces the first compartment; and

(iii) a liquid imbibing composition contained between the semipermeable wall and the impermeable wall; and

(c) outlet means extending from the first compartment through the housing through which said composition may be pumped.

5. The pump of claim 4 wherein the liquid imbibing member is mounted within the housing such that the member is not capable of movement other than the expansion of the expandable impermeable wall.

6. The pump of claim 5 wherein the liquid imbibing composition is itself a liquid and the injector includes means for manually exerting pressure on said liquid imbibing composition thereby causing the expandable impermeable wall to expand.

7. The pump of claim 6 wherein the liquid imbibing member includes a support member positioned between the liquid imbibing composition and the semipermeable wall, the support member having a plurality of axial holes opening to the semipermeable wall and the liquid imbibing composition and an axial opening defined by a cylindrical axially elongated collar that extends through the semipermeable wall into the second compartment and one end of said housing is capable of being depressed axially and carries a piston member that is received in the collar, whereby when said one end of said housing is depressed pressure is exerted on the liquid imbibing composition.

8. The pump of claim 7 wherein the exterior surface of the housing proximal the end capable of axial depression is threaded and said means for closing said end has interior threads in threaded engagement therewith whereby it may be screwed onto the housing to effect said axial depression.

9. The pump of claim 4 wherein the liquid imbibing member is slideably mounted in the housing such that the member is able to slide toward one end thereof and the injector pump includes

(d) manually operable means for exerting a force on the liquid imbibing member to cause it to slide within the housing toward said one end thereof.

10. The pump of claim 4 wherein the liquid imbibing member includes an axially slideable ring on which the semipermeable wall, expandable impermeable wall, and water imbibing composition are mounted and one of the ends of said housing is capable of being depressed axially to bear against the axially slideable ring and drive and liquid imbibing member toward said other end of said housing.

11. The pump of claim 10 wherein the interior surface of the housing provided the end capable of axial depression is threaded and said means for closing said end is in threaded engagement therewith whereby it may be screwed into the housing to effect said axial depression.

12. The pump of claim 10 including sealing means between the interior of the housing and the exterior of the axially slideable ring.

13. The pump of claim 4 wherein the liquid-imbibing member includes an axially slideable ring on which the semipermeable wall, expandable impermeable wall and liquid imbibing composition are mounted, said ring being connected to the one end of said housing which end is capable of being depressed axially thereby causing the liquid imbibing member to slide toward the other end of said housing.

14. The pump of claim 13 including sealing means between the interior of the housing and the exterior of the axially slideable ring.