Chewable capsules

• US 4,755,389 A
• Filed: 09/10/1986
• Issued: 07/05/1988
• Est. Priority Date: 09/11/1985
• Status: Expired due to Term

• Current Assignee: Shionogi Europe BV (Mitsubishi Chemical Group Corp.)
• Original Assignee: Lilly Industries Limited
• Inventors: Walker, Mark A., Knight, Paula M., Jones, Brian E.
• Primary Examiner(s): Swisher, Naney A. B.
• Application Number:
  US06/905,905
• Time in Patent Office: 664 Days
• Field of Search: 424/456, 424/485, 424/441
• US Class Current: 424/456
• CPC Class Codes: A61K 9/0056 Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
• CPC Class Codes: A61K 9/006 Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
• CPC Class Codes: A61K 9/4858 Organic compounds
• CPC Class Codes: A61K 9/4866 Organic macromolecular compounds

Abstract

A hard gelatin capsule is filled with a chewable composition containing an ingredient for buccal absorption or having buccal activity.

Claims

1. A hard gelatin capsule containing a chewable composition which comprises (a) a semi-solid composition comprising an ingredient for buccal absorption or having buccal activity in association with a non-toxic carrier and (b) a masticatory enhancing agent, said chewable composition being liquid at a temperature below 100°

C.

3. A capsule as claimed in claim 1 or claim 2, wherein the masticatory agent is a stabilizing or suspending agent.

4. A capsule as claimed in claim 3, wherein the masticatory agent is a gum.

5. A capsule as claimed in claim 4, wherein the gum is Xanthan gum.

9. A capsule as claimed in any one of claims 1 or 2 wherein the composition comprises up to 95% by weight of active ingredient.

11. A capsule as claimed in claims 1 or 2 wherein the active ingredient is a cardioactive drug or an analgesic drug.

12. A capsule as claimed in claim 1 wherein the ingredient for buccal absorption or having buccal activity is a liquid and the carrier is a solid.

13. A capsule as claimed in claim 12 wherein the carrier is colloidal silicon dioxide or a cellulose derivative.

14. A capsule as claimed in claims 1 or 2 additionally containing a flavouring agent.

2. A hard gelatin capsule containing a chewable composition which comprises (a) an ingredient for buccal absorption or having buccal activity, (b) a non-toxic semi-solid carrier and (c) a masticatory enhancing agent, said chewable composition being liquid at a temperature below 100°

C.

6. A capsule as claimed in claim 2, wherein the carrier is a polyethylene glycol having a molecular weight in the range 200-10,000.

7. A capsule as claimed in claim 6, wherein the carrier is a polyethylene glycol having a molecular weight in the range 400-4,000.

8. A capsule as claimed in claim 7, wherein the PEG has a molecular weight in the range 1000 to 2000.

10. A capsule as claimed in claim 2, wherein the composition comprises from up to 20% of a solid active ingredient.