Spartein compounds, their preparation and use

• US 4,755,520 A
• Filed: 06/17/1986
• Issued: 07/05/1988
• Est. Priority Date: 06/22/1985
• Status: Expired due to Fees

• Current Assignee: Solvay Pharmaceuticals GmbH (Abbvie Incorporated)
• Original Assignee: Kali-Chemie Pharma GmbH
• Inventors: Kuhl, Ulrich G., Buschmann, Gerd, Schon, Uwe, Hachmeister, Bernd, Kehrbach, Wolfgang
• Primary Examiner(s): Daus, Donald G.
• Assistant Examiner(s): Teoli, Jr., William A.
• Application Number:
  US06/875,311
• Time in Patent Office: 749 Days
• Field of Search: 546/63, 514/286
• US Class Current: 514/286
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/06 Antiarrhythmics
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07D 471/22 in which the condensed systems contains four or more hetero rings

Abstract

Compounds of Formula (I)

S--(CH.sub.2).sub.n --A                                    (I)

in which

S is a 17-spartein nucleus

n is 0 or 1

and A is 2-furyl, 2-thienyl or 2-(N-alkyl)pyrryl when n=0, or 3-furyl or 3-thienyl when n=1, or pyridyl or a phenyl group of Formula (II) ##STR1## in which at least one of R₁, R₂ and R₃ is a defined substituent other than hydrogen. Such compounds and corresponding compounds in which A is an unsubstituted phenyl group are useful in pharmaceutical compositions as heart affecting agents. Methods of preparing such compounds and pharmaceutical compositions are also disclosed.

Claims

1. A compound corresponding to the Formula (I)

View Dependent Claims (2, 3)

2. A compound according to claim 1, wherein A is 3-methoxyphenyl or 2-chlorophenyl.

3. A compound according to claim 2, wherein A is 3-methoxyphenyl.

4. A pharmaceutical composition comprising a pharmaceutically suitable carrier or adjuvant and a compound corresponding to Formula (I)

View Dependent Claims (5)

5. A pharmaceutical composition according to claim 4, wherein A is 3-methoxyphenyl.