Rate responsive pacing using the ventricular gradient

• US 4,759,366 A
• Filed: 03/19/1986
• Issued: 07/26/1988
• Est. Priority Date: 03/19/1986
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Telectronics Incorporated
• Inventors: Callaghan, Frank J.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US06/841,517
• Time in Patent Office: 860 Days
• Field of Search: 128/419, 128/702-704, 128/707
• US Class Current: 607/26
• CPC Class Codes: A61N 1/36507 controlled by gradient or slope of the heart potential
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold

Abstract

A rate responsive cardiac pacing system is provided. In the illustrative embodiment, electrical stimulus pulses are applied to the heart ventricle and the evoked potential of the applied electrical stimulus pulses is detected. The detected potential is integrated over time to obtain a depolarization gradient and a repolarization gradient. A peak to peak time interval is determined from the peak of the depolarization gradient to the peak of the repolarization gradient. The peak to peak time interval is compared to the peak to peak time interval of at least one previous cardiac cycle. The rate of the electrical stimulus pulses is controlled in response to this comparison.

Claims

1. A cardiac pacing method which comprises the steps of:

applying electrical stimulus pulses to the heart;

detecting a cardiac event potential;

integrating the detected potential over time to obtain the depolarization gradient and a repolarization gradient;

sensing the peak of the depolarization gradient;

sensing the peak of the repolarization gradient;

determining the peak to peak time interval from the depolarization gradient peak to the repolarization gradient peak;

storing said peak to peak time interval;

comparing said peak to peak time interval with a corresponding peak to peak time interval of at least one previous cardiac cycle that has been stored; and

controlling the rate of said electrical stimulus pulses in response to said comparison.

2. A cardiac pacing method as described in claim 1, in which said cardiac event potential is a natural ventricular event potential.

3. A cardiac pacing method as described in claim 1, in which said cardiac event potential is an evoked potential.

4. A cardiac pacing method as described in claim 1, including the step of inhibiting the application of a stimulus pulse if a natural ventricular event is sensed within a predetermined time period.

5. A cardiac pacing method as described in claim 1, in which the rate controlling step includes the steps of not changing the pacing rate if the compared peak to peak time intervals are equal, varying the pacing rate in one direction if the peak to peak time interval is less than the prior value, and varying the pacing rate in the opposite direction if the peak to peak time interval is greater than the prior value.

6. A cardiac pacing method as described in claim 5, in which the controlling step includes the steps of not changing the pacing rate if the compared peak to peak time intervals are equal, increasing the pacing rate if the peak to peak time interval is less than the prior value, and decreasing the pacing rate if the peak to peak time interval is greater than the prior value.

7. A method as described in claim 6, in which the rate controlling step comprises the following steps:

if the peak to peak time interval is less than the prior value, then determining if the pacing rate is at a predetermined maximum; and

if the pacing rate is at a predetermined maximum, then not changing the pacing rate, but if the pacing rate is less than said predetermined maximum then increasing the pacing rate; and

if the peak to peak time interval is greater than the prior value, then determining whether the pacing rate is at a predetermined minimum value, and if the pacing rate is at a predetermined minimum value, then not changing the pacing rate, but if the pacing rate is greater than said predtermined minimum, then decreasing the pacing rate.

8. A method as described in claim 6, including the step of inhibiting the application of a stimulus pulse if a natural ventricular event is sensed within a predetermined time period.

9. A cardiac pacing method which comprises the steps of:

applying electrical stimulus pulses to the heart;

detecting a cardiac event potential;

integrating the detected potential over time to obtain a depolarization gradient and a repolarization gradient;

sensing the peak of the depolarization gradient;

sensing the peak of the repolarization gradient;

determining the peak to peak time interval from the depolarization gradient peak to the repolarization gradient peak;

comprising said peak to peak time interval with a target value; and

controlling the rate of said electrical stimulus pulses in response to said comparison.

10. A cardiac pacing method as described in claim 9, in which said cardiac event potential is a natural ventricular event potential.

11. A cardiac pacing method as described in claim 9, in which said cardiac event potential is an evoked potential.

12. A cardiac pacing method as described in claim 9, including the step of inhibiting the application of a stimulus pulse if a natural ventricular event is sensed within a predetermined time period.

13. A cardiac pacing method as described in claim 9, in which the rate controlling step includes the steps of not changing the pacing rate if the compared peak to peak time interval and target value are equal, varying the pacing rate in one direction if the peak to peak time interval is less than the target value, and varying the pacing rate in the opposite direction if the peak to peak time interval is greater than the target value.

14. A cardiac pacing method as described in claim 13, in which the controlling step includes the steps of not changing the pacing rate if the compared values are equal, increasing the pacing rate if the time interval is less than the target value, and decreasing the pacing rate if the time interval is greater than the target value.

15. A method as described in claim 14, in which the rate controlling step comprises the following steps:

if the time interval is less than the target value, then determining if the pacing rate is at a predetermined maximum; and

if the pacing rate is at a predetermined maximum, then not changing the pacing rate, but if the pacing rate is less than said predetermined maximum then increasing the pacing rate; and

if the time interval is greater than the target value, then determining whether the pacing rate is at a predetermined minimum value, if the pacing rate is at a predetermined minimum value, then not changing the pacing rate, but if the pacing rate is greater than said predetermined minimum then decreasing the pacing rate.

16. A cardiac pacing method which comprises the steps of:

applying electrical stimulus pulses to the heart;

detecting a cardiac event potential;

integrating the detected potential over time to obtain a depolarization gradient and a repolarization gradient;

sensing the peak of the depolarization gradient;

sensing the peak of the repolarization gradient;

determining the peak to peak time interval from the depolarization gradient to the repolarization gradient peak;

comparing the peak to peak time interval with a target value;

controlling the rate of said electrical stimulus pulses in response to said comparison, said controlling step including the steps of not changing the pacing rate if the compared values are equal, increasing the pacing rate if the time interval is less than the target value, and decreasing the pacing rate if the time interval is greater than the target value;

if the time interval is less than the target value, then determining if the pacing rate is at a predetermined maximum; and

if the pacing rate is at a predetermined maximum, then not changing the pacing rate, but if the pacing rate is less than said predetermined maximum then increasing the pacing rate; and

if the time interval is greater than the target value, then determining whether the pacing rate is at a predetermined minimum value; and

if the pacing rate is at a predetermined minimum value, then not changing the pacing rate, but if the pacing rate is greater than said predetermined minimum then decreasing the pacing rate; and

inhibiting the application of a stimulus pulse if a natural ventricular event is sensed within a predetermined time period.