Drug delivery system comprising a volume increasing matrix containing a plurality of tiny pills
First Claim
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1. A tablet dosage form for the controlled delivery of an orally administrable beneficial drug to the gastrointestinal tract for executing a therapeutic program over a prolonged period of time, the tablet dosage form comprising:
- (1) a tablet matrix hydrogel which absorbs and imbibes water, and swells and expands and increases in size or volume, and, in the expanded state, acts as a means for stomach retention for an extended period of time comprising a pharmaceutically acceptable starch fraft copolymer composition; and
,(2) a plurality of tiny pills housed throughout the tablet matrix, the tiny pills comprising;
(a) a dosage amount of an orally administrable beneficial drug; and
,(b) a wall surrounding the drug, the wall comprising a cellulose composition selected from the group consisting of cellulose acylate, cellulose diacylate, cellulose triacylate and ethyl cellulose.
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Abstract
A delivery device is disclosed for delivering a beneficial drug to a biological environment of use. The device comprises a hydrogel reservoir containing tiny pills. The tiny pills comprise a wall surrounding a drug core.
75 Citations
1 Claim
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1. A tablet dosage form for the controlled delivery of an orally administrable beneficial drug to the gastrointestinal tract for executing a therapeutic program over a prolonged period of time, the tablet dosage form comprising:
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(1) a tablet matrix hydrogel which absorbs and imbibes water, and swells and expands and increases in size or volume, and, in the expanded state, acts as a means for stomach retention for an extended period of time comprising a pharmaceutically acceptable starch fraft copolymer composition; and
,(2) a plurality of tiny pills housed throughout the tablet matrix, the tiny pills comprising; (a) a dosage amount of an orally administrable beneficial drug; and
,(b) a wall surrounding the drug, the wall comprising a cellulose composition selected from the group consisting of cellulose acylate, cellulose diacylate, cellulose triacylate and ethyl cellulose.
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Specification
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Current AssigneeALZA Corporation (Johnson & Johnson)
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Original AssigneeALZA Corporation (Johnson & Johnson)
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InventorsTheeuews, Felix, Urquhart, John
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Primary Examiner(s)Rose, Shep K.
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Application NumberUS07/014,944Time in Patent Office550 DaysField of Search604/892, 424/458, 424/461, 424/464, 424/465, 424/468, 424/469, 424/474, 424/480, 424/484, 424/486, 424/487, 424/488, 424/489, 424/490, 424/494, 424/497, 424/501US Class Current424/465CPC Class CodesA61K 9/0065 Forms with gastric retentio...A61K 9/2077 Tablets comprising drug-con...
