Device for controlled release drug delivery
First Claim
1. A device for the controlled release and delivery of a pharmacologically active agent, comprising a gelled vinyl plastisol layer and a pharmacologically active agent uniformly dispersed in the layer in a pharmacologically effective amount,said vinyl layer comprising an emulsion polymerized polyvinyl chloride resin, a primary plasticizer for the polyvinyl chloride resin, and an organic, nonvolatile gel forming additive in an amount sufficient to form a gel.
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Accused Products
Abstract
A device for the controlled release and delivery of a pharmacologically active agent, comprising a vinyl gel layer and a pharmacologically active agent uniformly dispersed in the layer in a pharmacologically effective amount, the vinyl layer comprising an emulsion polymerized polyvinyl chloride resin, a primary plasticizer for the polyvinyl chloride resin, and an organic, nonvolatile gel forming additive in an amount sufficient to form a gel.
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Citations
28 Claims
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1. A device for the controlled release and delivery of a pharmacologically active agent, comprising a gelled vinyl plastisol layer and a pharmacologically active agent uniformly dispersed in the layer in a pharmacologically effective amount,
said vinyl layer comprising an emulsion polymerized polyvinyl chloride resin, a primary plasticizer for the polyvinyl chloride resin, and an organic, nonvolatile gel forming additive in an amount sufficient to form a gel.
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28. A method for the transdermal delivery of nitroglycerin to a patient to provide said patient with nitroglycerin, comprising applying to said patient a device for the controlled release and delivery of nitroglycerin, the device comprising a vinyl gel layer and nitroglycerin uniformly dispersed in the layer in a pharmacologically effective amount, the vinyl layer comprising an emulsion polymerized polyvinyl chloride resin, a primary plasticizer for the polyvinyl chloride resin, and an organic, nonvolatile gel forming additive in an amount sufficient to form a gel.
Specification