Wearable, continuously internally operable and externally regenerable dialysis device

• US 4,765,907 A
• Filed: 10/18/1984
• Issued: 08/23/1988
• Est. Priority Date: 03/28/1984
• Status: Expired due to Fees

• Current Assignee: Research Development Systems Incorporated
• Original Assignee: Research Development Systems Incorporated
• Inventors: Scott, Robert D.
• Primary Examiner(s): Spear, Frank
• Application Number:
  US06/662,250
• Time in Patent Office: 1,405 Days
• Field of Search: 210/648, 210/321.3, 210/321.4, 210/321.2, 210/321.78, 604/27, 604/28, 604/29, 128/DIG. 3
• US Class Current: 210/648
• CPC Class Codes: A61M 1/1678 intracorporal peritoneal dialysis A61M1/28
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/28 Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
• CPC Class Codes: A61M 1/284 Continuous flow peritoneal dialysis [CFPD]
• CPC Class Codes: A61M 2209/088 on the body
• CPC Class Codes: A61M 2210/1017 Peritoneal cavity

Abstract

Wearable, continuously internally operable, externally regenerable dialysis system in which body fluids are dialyzed against a first dialysis fluid within a chamber in the body without invasion of veins or arteries, the chamber being a body cavity or a semi-permeable wall within the body, the dialysis fluid being regenerated in a chamber outside the body against a second dialysis fluid which is continuously regenerated in a belt supported apparatus, the internal and external chambers being in fluid communication.

Claims

1. Wearable, continuously internally operable and externally regnerable dialysis device comprising means concurrently dialyzing a confined dialysis dluid against body fluids within the body intestines and regenerating said dialysis fluid outside the body.

2. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 1, in which said means includes pump means for exchanging said dialysis fluid from within and outside the body.

3. Wearable, continuously internally operable and externally regenerable dialysis device according to to claim 1, in which said means includes an internal chamber disposed within the body for confining said dialysis fluid, said chamber having a semipermeable wall adapted to dialysis.

4. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 1, in which said means includes an external chamber disposed outside the body, said external chamber having a semipermeable wall for dialyzing spent dialysis fluid there against a regenerating fluid.

5. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 1, in which said means includes conduit means continuously communicating the confined portion of said dialysis fluid with dialysis fluid outside the body.

6. Wearable, continuously internally operable and externally regenerable dialysis device comprising a body fluid-dialyzing semipermeable generally tubular internal chamber resistant to deterioration from exposure within the body, and an external chamber, said internal chamber being adapted to extended disposition within a user'"'"'s body intestines in body fluid-dialzying relation and freely of interior communication with veins and arteries, said external chamber being in continuous open communication with said internal chamber, a pump to exchange a first dialysis fluid between said internal chamber and said external chamber, and means to regenerate said first dialysis fluid during passage through said external chamber for return to said internal chamber.

7. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 6, in which said internal chamber is elongated and located inward of the peritoneum, and including also a continued extent of said chamber defining a conduit for passing first dialysis fluid through said peritoneum.

8. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 7, in which said internal chamber comprises a section of the large or small intestine out of interior fluid communication with the intestine from which it is take, but constituted of common living tissue therewith.

9. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 8, in which said external chamber is an elongated tube adapted to contain said first dialysis fluid, and including also an envelope surrounding said tube for holding said second dialysis fluid against said tube in dialyzing relation to regenerate said first dialyzing fluid.

10. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 9, in which said envelope comprises a second tube surrounding said external chamber tube along its length.

11. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 9, including also valve means selectively openable to draw said second dialysis fluid from said envelope.

12. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 9, in which said means to exchange said first dialysis fluid includes a first pump in open communication with said internal and external chambers.

13. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 12, including also means to regenerate said first dialysis fluid by addition or subtraction of components for dialysis in said first dialysis fluid.

14. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 13, including also a waist encircling belt carrying said envelope and supporting said external chamber therein, and belt-carried means supporting said first pump and regenerating means at the hip region of the wearer.

15. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 14, in which said external chamber is disposed within said belt in multiply reverse-turned relation, and including also a second pump for circulating said second dialysis fluid through said envelope.

16. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 12, in which said means to exchange said first dialysis fluid includes a first pump in open communication with said chambers.

17. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 16, including also a second pump in open communication with said envelope, a solids adjustment zone in open communication with envelope comprising means selected from a filter means and a supply of second dialysis fluid make-up solids in flow communication with said zone for adding to or removing solids from said second dialysis fluid pumped by said pump.

18. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 17 in which said first and second pumps are external of the body.

19. Wearable, continuously internally operable and externally regenerable dialysis device comprising a body fluid dialyzing internal chamber sized and arranged to define an extended dialyzing interface with body fluids outside the veins and arteries of the user'"'"'s body, said internal chamber being integral with living tissue of the user'"'"'s intestine, and free of interior open communication with said intestine.

22. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 19, 20 or 21, including also means to exchange said first dialysis fluid from within the body into and through said external chamber for regeneration against a second dialysis fluid of different composition for adding or subtracting components form said circulating dialysis fluid according to the user'"'"'s need.

20. Wearable, continuously internally operable and externally regenerable dialysis device comprising a body fluid dialyzing internal chamber sized and arranged to define an extended dialzying interface with body fluids outside the veins and arteries of the user'"'"'s body, said internal chamber being defined by the living tissue of the user'"'"'s body, said internal chamber being defined by the living tissue of the user'"'"'s rectum, and free of interior open communication with the user'"'"'s intestine.

21. Wearable, continuously internally operable and externally regenerable dialysis device comprising a body fluid dialyzing internal chamber sized and arranged to define an extended dialzying interface with body fluids outside the veins and arteries of the user'"'"'s body, said internal chamber being defined by a closed semipermeable wall disposed within the user'"'"'s rectum free of interior open communication with the user'"'"'s intestine.

23. Wearable, continuously internally operable and externally regenerable dialysis device comprising a body fluid-dialzying internal chamber an external chamber in continuous open communication therewith, said internal chamber being defined at least in part by the rectum out of communication with the intestine and adapted to contain dialyzing fluid in body fluid-dialyzing relation, pump means to exchange a first dialysis fluid between said internal and external chambers and means to dialyze said first dialysis fluid in said external chamber for return to said internal portion and concurrently with said exchange.

24. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 23, including also said external chamber being an elongated tube, an envelope surrounding said tube, and a second dialyzing fluid within said envelope for regenerating said circulating dialysis fluid within said external chamber.

25. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 24, including also valve-controlled means to tap said second dialysis fluid from said envelope.

26. Wearable, continuously internally operable and externally regenerable dialysis device for a person having a by-passed rectum as by a colostomy, said device having an internal chamber and an external chamber, said internal chamber being defined by the rectum of the wearer, whereby fluids passed from the rectum interior wall, said external chamber comprising a body fluid-dialyzing relation with the rectum interior wall, said external chamber comprising a body fluid-dialyzing semipermeable chamber in open communication with said internal chamber, means to exchange dialysis fluid between said internal and external chambers, and means to regenerate said first dialysis fluid within said external chamber for return to said internal chamber for continuing body fluid dialysis.

27. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 26, including also a deflector adapted to deflect dialysis fluid within the rectum into dialyzing proximity with the rectum interior wall.

28. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 26, including also a closed semipremeable wall disposed within the rectum for confining said first dialysis fluid within the rectum.

29. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 27 or 28, in which said means to exchange dialysis fluid further includes means defining a first fluid passage to the rectum, and means defining a second fluid passage out of the rectum via the anus.

30. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 28, in which said external chamber is an elongated tube adapted to contain said first dialysis fluid, and including also an envelope surrounding said tube for holding said second dialysis fluid against said tube in dialyzing relation to regenerate said first dialyzing fluid.

31. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 30, in which said envelope comprises a second tube surrounding said external chamber tube along its length.

32. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 31, including also valve means selectively openable to draw an aliquot portion of said second dialysis fluid from said envelope.

33. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 32, in which said means to exchange said first dialysis fluid includes a first pump in open communication with said chambers.

34. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 33, including also means to regenerate said second dialysis fluid by addition or subtraction of components for dialysis of said first dialysis fluid.

35. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 34, in which said pump and regenerating means are body-external.

36. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 35, including also a waist encircling belt carrying said envelope and supporting said external chamber therein, and belt-carried means supporting said pump and regenerating means at the hip region of the wearer.

37. Wearable, continuously internally operable and externally regenerable dialysis device according to claim 36, in which said body-external portion is disposed within said belt in multiply reverse-turned relation.

38. Method for the continuous dialyzing of body fluid within the body, including urging a first dialysis fluid through the body intestines in body-fluid dialyzing relation and dialyzing said first dialysis against a second dialysis fluid differing in composition from said first dialysis fluid in first dialyzing fluid regenerating relation.

39. The method according to claim 38 including also disposing an internal chamber within and an external chamber without the user'"'"'s body freely of interior communication with veins and arteries of the body for exchange of said first dialysis fluid between said chambers, said external chamber comprising a semipermeable membrane, said internal chamber being in dialyzing communication with body fluids within the body, and said external chamber being in dialzying communication with said second dialysis fluid outside the body.

40. The method according to claim 39, including also employing a tissue of the user'"'"'s body to define the internal chamber in dialyzing communication with body fluids.

41. The method according to claim 40, including also selecting a section of the user'"'"'s intestine and connection said section be be common living tissue with said intestine but out of interior fluid communication therewith to define the internal chamber in dialyzing communication with body fluids.

42. The method according to claim 40, including also selecting a section of the user'"'"'s rectum isolated from the intestine to define the internal chamber, introducing said first dialyzing fluid thereinto and withdrawing said fluid at the anal opening, said fluid being diffused in dialzying contact with the rectum wall between said introduction and withdrawl.

43. The method according to claim 42, including also interposing a semipermeable wall between said first dialysis fluid and said rectum wall, whereby said semipermeable wall dialyzes body fluids within the rectum wall against said first dialysis fluid.

44. Method for dialysis including concurrently dialyzing a confined dialysis fluid against body fluids within the body intestines and regnerating said dialysis fluid outside the body.

45. The method according to claim 44, including also exchanging said dialysis fluid outside the body for dialysis fluid within the body to renew the dialysis fluid within the body.

46. The method according to claim 44, including also employing a section of the user'"'"'s body tissue to confine said dialysis fluid within the body.

47. The method according to claim 46, including also employing a semipermeable membrane to confine said dialysis fluid within the body.

48. The method according to claim 44, including also dialyzing spent dialysis fluid from within the body against a regenerating fluid outside the body.

49. The method according to claim 48, including also continuously exchanging the confined portion of said dialysis fluid with said dialysis fluid outside the body.

50. Method for internally dialyzing the body while externally regenerating the dialysis fluid including confining within the body intestines a common dialyzing fluid in body fluid dialyzing relation, regenerating said common dialysis fluid against a second dialysis fluid outside the body, and exchanging said regenerated dialysis fluid with said confined dialysis fluid.

51. The method according to claim 50, including also confining said common dialysis fluid within living tissue of the user.

52. The method according to claim 50, including also confining said common dialysis fluid within a semipermeable membrance.

53. The method according to claim 52, including also dialzying said semipermeable membrance confined fluid against the rectum wall of the user.