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Osmotic device for administering certain drugs

  • US 4,765,989 A
  • Filed: 09/02/1986
  • Issued: 08/23/1988
  • Est. Priority Date: 05/11/1983
  • Status: Expired due to Term
First Claim
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1. An osmotic device for the oral administration at a controlled rate the beneficial drug nifedipine to an environment of use, the osmotic device comprising:

  • (a) a wall comprising in at least a part of a semipermeable material permeable to the passage of an exterior fluid present in the environment of use and substantially impermeable to the passage of the beneficial drug, the wall surrounding and forming;

    (b) a compartment;

    (c) a first composition in the compartment, said first composition comprising the beneficial drug nifedipine and an osmopolymer that exhibits an osmotic pressure gradient across the wall against an external fluid;

    (d) a second composition in the compartment, said second composition comprising an osmopolymer that exhibits an osmotic pressure gradient across the wall against an external fluid; and

    ,(e) at least one passageway in the wall communicating with the first composition and the exterior of the device for delivering the beneficial drug nifedipine through the passageway from the osmotic device.

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