Iontophoretic administration of ionizable or polar medicaments to a mammalian body

• US 4,767,401 A
• Filed: 08/26/1982
• Issued: 08/30/1988
• Est. Priority Date: 04/22/1975
• Status: Expired due to Fees

• Current Assignee: Maurice Seiderman
• Original Assignee: Maurice Seiderman
• Inventors: Seiderman, Maurice
• Primary Examiner(s): Cohen, Lee S.
• Application Number:
  US06/411,657
• Time in Patent Office: 2,196 Days
• Field of Search: 128/82.1, 128/419 R, 128/803, 604/20
• US Class Current: 604/20
• CPC Class Codes: A61F 13/00063 comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic drug delivery dressings A61K9/70; chemical aspect of the additives A61L15/00
• CPC Class Codes: A61F 2013/00157 for burns or skin transplants A61F2013/00187 takes precedence; not adhering to the wound A61F2013/00217
• CPC Class Codes: A61F 2013/00221 biodegradable, non-irritating
• CPC Class Codes: A61F 2013/00519 for treating burn bandages for burns or skin transplants A61F2013/00157
• CPC Class Codes: A61F 2013/00927 with biological activity, e.g. enzymes for debriding wounds or others, collagen or growth factors
• CPC Class Codes: A61F 2013/00936 metal wound bandages with a metallic layer A61F2013/00234
• CPC Class Codes: A61L 15/325 Collagen
• CPC Class Codes: A61N 1/0428 Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
• CPC Class Codes: A61N 1/0436 Material of the electrode

Abstract

A method for the iontophoretic administration of topical or systemic ionizable or polar medicaments to a mammalian body, and articles adapted therefor, are disclosed.

Claims

1. A bandage for iontophoretically administering a topical or systemic ionizable or polar medicament to a mammalian body having a wound, lesion, or the like thereon, comprising:

(a) a substrate

(b) an ionizable or polar medicament borne on said substrate, which medicament is responsive, in terms of migration to an electric field; and

(c) a single electrode of an electrochemically-active material in electrically cooperative relationship with said medicament, for generating an iontophoretically effective, localized electric current between said medicament and the mammalian body to which the bandage is applied, to thereby cause the medicament to migrate deeply within said wound, lesion, or the like upon activation of the bandage by electrolytic fluids.

2. The bandage of claim 1, wherein said substrate defines a medial portion bounded by terminal portions, said electrode borne upon said substrate within said medial portion and supporting a discrete quantity of said medicament within its peripheral dimensions, said electrode presenting sufficient surface area for contact with said body to establish an iontophoretically-effective electric current between said medicament and said body to cause migration of said medicament deeply within said wound, lesion, or the like thereon.

3. The bandage of claim 1, wherein said substrate defines a medial portion bounded by terminal portions, said medicament borne upon said substrate within said medial portion, said electrode being confined to at least one of said terminal portions and partially overlapping said medial portion in electrically-cooperative relationship with said medicament.

4. The bandage of claim 1, wherein said medicament is absorbed within a carrier selected from the group consisting of sterile paper, sterile cloth, and hydrogel polymers, said carrier being adhered to said bandage.

5. The bandage of claim 1, wherein said medicament is a proteinaceous medicament.

6. The bandage of claim 5, wherein said proteinaceous medicament is comprised of an undenatured protein.

7. The bandage of claim 5, wherein said proteinaceous medicament is comprised of a denatured protein.

8. The bandage of claim 7, wherein said proteinaceous medicament further comprises a bio-compatible metallic medicament.

9. The bandage of claim 8, wherein the metal is silver.

10. The bandage of claim 5, wherein said medicament is silver protein.

11. The bandage of claim 10, wherein said electrode is aluminum metal.

12. The bandage of claim 11, wherein said aluminum is applied as either a foil or as a paint.

13. A method for iontophoretically administering a topical or systemic ionizable or polar medicament to a mammalian body having a wound, lesion, or the like thereon, whereby said medicament is responsive, in terms of migration, to an electric field, comprising the step of generating an electric field by voltaic interaction between a single electrode of electrochemically-active material borne upon a bandage substrate and in electrically-cooperative relationship with said medicament, and said body when said bandage substrate is placed over said wound, lesion, or the like, upon activation of the bandage by electrolytic fluids, whereby the medicament is caused to migrate deeply within said wound, lesion, or the like.

14. The method of claim 13, wherein said medicament is a proteinaceous medicament.

15. The method of claim 14, wherein said proteinaceous medicament is comprised of an undenatured protein.

16. The method of claim 14, wherein said proteinaceous medicament is comprised of a denatured protein.

17. The method of claim 16, wherein said proteinaceous medicament further comprises a bio-compatible metallic medicament.

18. The method of claim 17, wherein the metal is silver.

19. The method of claim 14, wherein said medicament is silver protein and said electrode is a metal foil capable of establishing a net positive electric charge with respect to said body.

20. The method of iontophoretically adminstering an ionizable or polar medicament as defined by claim 13, wherein said medicament is in a dry state, said method further comprising the step of hydrating said medicament with an electrolyte fluid.

21. The method of claim 20, wherein said electrolyte fluid is either the fluid within the wound, lesion, or the like or is isotonic saline.

22. The method of claim 20, wherein said electrode is aluminum foil.