Ultrasound enhancement of transdermal drug delivery
First Claim
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1. A method for enhancing and controlling transdermal infusion of molecules comprising:
- (a) selecting the molecules having a low rate of permeability through the skin to be infused;
(b) applying to the skin said molecules in a medium with an absorption coefficient similar to that of water;
(c) applying ultrasound to said molecules in said medium at a frequency of between 20 kHz and 10 MHz and an intensity of between 0 and 3 W/cm2 ; and
(d) varying the frequency and intensity over time to transdermally infuse said molecules at an optimal rate into the circulatory system without delay or damaging the skin, wherein the optimal rate is determined by measurements of a physiological fluid.
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Abstract
The present invention is a method using ultrasound to enhance permeation of molecules through the skin and into the blood stream, at a controlled rate. Depending on the drug being infused through the skin, the rate of permeation is increased as well as the efficiency of transfer. Drugs which may not be effective under other conditions, for example, due to degradation within the gastrointestinal tract, can be effectively conveyed transdermally into the circulatory system by means of ultrasound.
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Citations
12 Claims
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1. A method for enhancing and controlling transdermal infusion of molecules comprising:
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(a) selecting the molecules having a low rate of permeability through the skin to be infused; (b) applying to the skin said molecules in a medium with an absorption coefficient similar to that of water; (c) applying ultrasound to said molecules in said medium at a frequency of between 20 kHz and 10 MHz and an intensity of between 0 and 3 W/cm2 ; and (d) varying the frequency and intensity over time to transdermally infuse said molecules at an optimal rate into the circulatory system without delay or damaging the skin, wherein the optimal rate is determined by measurements of a physiological fluid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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