Therapeutic and diagnostic processes using isotope transfer to chelator-target recognition molecule conjugate
First Claim
1. An in vivo diagnostic method, which comprises:
- (1) forming a diagnostic agent labeled with a radioactive metal ion by contacting(i) an unlabeled diagnostic agent comprising(a) a molecularly recognizable portion attached to(b) a chelating portion capable of substantially chelating with said radioactive metal ion, wherein said chelating portion is not a part of said molecularly recognizable portion, with(ii) an ion transfer material having said radioactive metal ion bound thereto and having a binding affinity for said radioactive metal ion less than the binding affinity of said chelating portion for said radioactive metal ion.wherein, prior to said contacting, said chelating portion is unchelated or is chelated with a second metal having a binding affinity with said chelating portion less than the binding affinity of said radioactive metal ion, whereby a radiolabeled diagnostic agent is formed by said contacting; and
(2) separtating, if necessary, said ion transfer material from said radiolabeled diagnostic agent;
(3) administering said agent to a human or animal; and
(4) detecting radiation emitted by said radioactive metal ion.
1 Assignment
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Accused Products
Abstract
A method of forming a therapeutic or diagnostic agent labeled with a radioactive metal ion, which comprises: contacting an unlabeled therapeutic or diagnostic agent, consisting of a substantially non-metal chelating portion and a chelating portion capable of chelating with the radioactive metal ion, with an ion transfer material having the radioactive metal ion bound thereto and having a binding affinity for the radioactive metal less than the binding affinity of the chelating portion for the radioactive metal ion, wherein prior to contacting the chelating portion is unchelated or is chelated with a second metal having a binding affinity with the chelating portion less than the binding affinity of the radioactive metal ion, whereby a radiolabeled therapeutic or diagnostic agent is formed by the contacting, and separating the radiolabeled therapeutic or diagnostic agent from the ion transfer material, is disclosed along with various components and kits useful in practicing this method and several variations thereof.
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Citations
27 Claims
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1. An in vivo diagnostic method, which comprises:
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(1) forming a diagnostic agent labeled with a radioactive metal ion by contacting (i) an unlabeled diagnostic agent comprising (a) a molecularly recognizable portion attached to (b) a chelating portion capable of substantially chelating with said radioactive metal ion, wherein said chelating portion is not a part of said molecularly recognizable portion, with (ii) an ion transfer material having said radioactive metal ion bound thereto and having a binding affinity for said radioactive metal ion less than the binding affinity of said chelating portion for said radioactive metal ion. wherein, prior to said contacting, said chelating portion is unchelated or is chelated with a second metal having a binding affinity with said chelating portion less than the binding affinity of said radioactive metal ion, whereby a radiolabeled diagnostic agent is formed by said contacting; and (2) separtating, if necessary, said ion transfer material from said radiolabeled diagnostic agent; (3) administering said agent to a human or animal; and (4) detecting radiation emitted by said radioactive metal ion. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A therapeutic process which comprises:
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(1) forming a therapeutic agent labeled with a radioactive metal ion by contacting (i) an unlabeled therapeutic agent comprising (a) a molecularly recognizable portion attached to (b) a chelating portion capable of substantially chelating with said radioactive metal ion, wherein said chelating portion is not a part of said molecularly recognizable portion, with (ii) an ion transfer material having said radioactive metal ion bound thereto and having a binding affinity for said radioactive metal ion less than the binding affinity of said chelating portion for said radioactive metal ion. wherein, prior to said contacting, said chelating portion is unchelated or is chelated with a second metal having a binding affinity with said chelating portion less than the binding affinity of said radioactive metal ion, whereby a radiolabeled therapeutic agent is formed by said contacting; and (2) separating, if necessary, said ion transfer material radiolabeled therapeutic agent; (3) administering said agent to a human or animal wherein said agent selectively localizes in a target region of said human or animal, therety concentrating radiation from said radioactive metal ion in said target region. - View Dependent Claims (8, 9, 10, 11, 12)
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13. A kit suitable for forming an in vivo therapeutic or diagnostic agent labeled with a radioactive metal ion, which comprises:
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(A) carrier means compartmentalized to receive in close confinement therein one or more containers; (B) a first container confined within said carrier and containing a therapeutic or diagnostic agent consisting of (1) a substantially non-metal chelating portion attached to (2) a chelating portion capable of chelating with a radioactive metal ion; and (C) a second container confined within said carrier and containing an ion transfer material capable of binding said radioactive metal ion bound thereto wherein the binding affinity of said ion transfer material for said radioactive metal ion is less than the binding affinity of said chelating portion for said radioactive metal ion. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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Specification