Method and apparatus for calibrating plural pump fluid flow system

• US 4,769,001 A
• Filed: 11/27/1985
• Issued: 09/06/1988
• Est. Priority Date: 02/25/1987
• Status: Expired due to Term

• Current Assignee: Baxter International Inc.
• Original Assignee: Baxter International Inc.
• Inventors: Prince, Paul R.
• Primary Examiner(s): NOT, DEFINED
• Assistant Examiner(s): Wilkens, Frank
• Application Number:
  US06/802,330
• Time in Patent Office: 1,014 Days
• Field of Search: 604/4, 604/5, 604/6, 604/53, 604/30, 604/246, 604/247, 604/80, 604/151, 604/31, 604/50, 604/65-67, 604/153, 604/118, 210/927, 210/97, 210/101, 210/102, 210/134, 137/14, 128/DIG. 13, 417/2, 417/5, 417/DIG. 3
• US Class Current: 604/6.07
• CPC Class Codes: A61M 1/3621 Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 1/3639 Blood pressure control, pressure transducers specially adapted therefor
• CPC Class Codes: A61M 1/3643 Priming, rinsing before or after use
• CPC Class Codes: A61M 1/3644 Mode of operation
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/70 with testing or calibration facilities
• CPC Class Codes: Y10S 128/13 Infusion monitoring

Abstract

A blood constituent processing system uses a disposable plastic fluid flow path into which an anticoagulant must be accurately metered with respect to pumped blood flow. In a preliminary calibration phase, a closed fluid flow path is provided between the anticoagulant pump and the blood pump. One of the pumps is then controlled to inject fluid into such closed path while the other pump is controlled to withdraw fluid from that path at what is nominally an equal fluid flow rate. Changes in fluid pressure within the closed fluid flow path are then monitored and the flow rate of at least one of the pumps is changed as necessary to achieve an approximately constant fluid pressure within the closed fluid flow path. The relative pump flow control required to achieve constant pressure may then be taken as a relative flow rate calibration between the two pumps so as to permit subsequent accurate pumped metering of anticoagulant into the pumped blood flow. A similar arrangement may be used to derive relative flow calibration constants for the blood pump and a packed cell pump also present in the blood constituent processing system.

Claims

1. A method for automatically deriving relative flow calibration data of plural pumps connected with a common fluid path therebetween, said method comprising the steps of:

automatically controlling said pumps to inject fluid into said common fluid path and/or to withdraw fluid from said common fluid pathat respectively associated nominal rates;

automatically measuring changes in at least one fluid flow parameter occurring within said common fluid path in response to said controlling of said pumps at said respectively associated nominal rates; and

automatically deriving relative flow calibration data for the individual pumps using said measured changes is obtained.

2. A method as in claim 1 wherein said controlling step comprises controlling a first pump to inject fluid into said path at a first nominal rate and controlling a second pump to withdraw fluid from said path at a second nominal rate, at least one of said rates being controlled to maintain an approximately constant fluid pressure in said path.

3. A method as in claim 1 wherein said controlling step comprises controlling a first pump to inject fluid into said path at a first nominal rate and controlling a second pump to withdraw fluid from said path at a second nominal rate, at least one of said rates being controlled to maintain an approximately constant fluid volume in said path.

4. A method as in claim 1 wherein:

said controlling step comprises controlling a first pump to inject fluid into said path at a first nominal rate and controlling a second pump to withdraw fluid from said path at a second nominal rate; and

said measuring step comprises measuring the rate-of-change in fluid pressure in said path.

5. A method for deriving relative flow calibration data for plural pumps connected with a common fluid path, said method comprising the step of:

measuring the relative pump flow controls which are required to maintain an approoxiamtely constant fluid pressure in said path while one pump is injecting fluid into said path and another pump is withdrawing fluid from said path.

6. A method for deriving relative flow calibration data for plural pumps connected with a common fluid path, said method comprising the step of:

measuring the relative pump flow controls which are required to maintain an approximately constant fluid volume in said path while one pump is injecting fluid into said path and another pump is withdrawing fluid from said path.

7. A method for deriving relative flow calibration data for an anticoagulant pump and a blood pump connected in a blood constituent processing system with a disposable plastic tubing which includes a common fluid path, said method comprising the steps of:

installing a disposable plastic tubing into a blood constituent processing system and providing a common closed fluid path within the disposable tubing and extending between an anticoagulant pump and a blood pump;

controlling the pumps to inject and/or withdraw fluid from said path at respective nominal rates;

measuring a predetermined fluid parameter in said path during said controlling step; and

deriving said relative flow characteristics in response to the controlling and/or measuring steps.

8. A method as in claim 7 wherein said controlling step comprises simultaneously (a) controlling a first pump to inject fluid into said path at a first nominal rate, (b) controlling a second pump to withdraw fluid from said path at a second nominal rate, and (c) changing at least one of said controlled nominal rates so as to maintain an approximately constant measured fluid pressure or volume in said path.

9. A method as in claim 8 wherein said deriving step comprises recording the relationship between the nominal pump flow rates required to maintain said approximately constant fluid pressure.

10. A method as in claim 7 wherein said deriving step comprises measuring the time-based rate of pressure change in said path.

11. A method for obtaining a relative flow calibration factor for a system of plural pumps connected with a common fluid flow path, said method comprising:

controlling at least two of the pumps to simultaneously inject and withdraw fluid from said path at relative rates which approximately maintain a constant fluid pressure or volume within said path; and

measuring at least one relative pump flow calibration factor for said at least two pumps based on the controlled pumping rates required to approximately maintain said constant fluid pressure or volume.

12. A method for calibrating relative pump flow rates of plural pumps connected with a common fluid-containing structure, said method comprising:

controlling at least one of said pumps to pump liquid into said structure at a first nominal rate;

simultaneously controlling at least one other of said pumps to pump liquid out of said structure at a second nominal rate;

monitoring the fluid pressure or volume within said structure during said controlling step; and

adjusting at least one of said nominal pump rates in response to said monitored fluid pressure or volume so as to obtain calibration data representing calibrated relative pump flow rates between plural pumps.

13. A method for calibrating a first pump flow with respect to a second pump flow in a blood constituent processing system, said method comprising the steps of:

installing a disposable plastic tubing into said blood constituent processing system which includes a common fluid flow path between said first pump and said second pump;

pumping fluid into said path with one of said pumps at a first predetermined nominal rate and pumping fluid out of said path with the other of said pumps at a second predetermined nominal rate, which rates are initially set to be at assumed equal values;

detecting changes in fluid pressure or volume within said path caused by said pumping step;

adjusting at least one of said first and second rates in response to said detecting step so as to maintain an approximately constant fluid pressure or volume within said path; and

deriving a relative pump flow calibration factor based on the controlled nominal flow rates required by said adjusting step.

14. Apparatus for deriving relative flow calibration data for plural pumps connected with a common fluid path, said apparatus comprising:

means for controlling said pumps to inject fluid into said path and/or to withdraw fluid from said path at respectively associated nominal rates;

means for measuring changes in at least one fluid flow parameter occuring within said path in response to said injection of fluid into, and withdrawal of fluid from, said common fluid path; and

means for deriving relative flow calibration data for the individual pumps in response to said measured changes.

15. Apparatus as in claim 14 wherein said means for controlling controls a first pump to inject fluid into said path at a first nominal rate and controls a second pump to withdraw fluid from said path at a second nominal rate which is controlled to maintain an approximately constant fluid pressure or volume in said path.

16. Apparatus as in claim 14 wherein:

said means for controlling controls a first pump to inject fluid into said path at a first nominal rate and controls a second pump to withdraw fluid from said path at a second nominal rate; and

said means for measuring measures the rate-of-change in fluid pressure or volume in said path.

17. Apparatus for deriving relative flow calibration data of plural pumps connected with a common closed fluid path, said apparatus comprising:

means for independently controlling plural pumps connected with a common closed flow path; and

means for measuring the relative pump flow controls which are required to maintain an approximately constant fluid pressure or volume in said path while one pump is injecting fluid into said path and another pump is withdrawing fluid from said path.

18. Apparatus for deriving relative flow calibration data of first and second pumps connected in a blood constituent processing system with a disposable plastic tubing which includes a common fluid path between said pumps, said apparatus comprising:

a disposable plastic tubing disposed in a blood constituent processing system and providing a common closed fluid path within the disposable tubing and extending between said first pump and said second pump;

means for controlling the pumps to inject and/or withdraw fluid from said path at respective nominal rates;

means for measuring a predetermined fluid parameter in said path; and

means for deriving said relative flow calibration data in response to the effected pump control and/or the measured parameter.

19. Apparatus as in claim 18 wherein said means for controlling simultaneously (a) controls a first pump to inject fluid into said path at a first nominal rate, (b) controls a second pump to withdraw fluid from said path at a second nominal rate, and (c) changes at least one of said controlled nominal rates in response to said means for measuring so as to maintain an approximately constant measured fluid pressure in said path.

20. Apparatus as in claim 19 wherein said means for deriving records the relationship between the nominal pump flow rates required to maintain said approximately constant fluid pressure.

21. Apparatus as in claim 18 wherein said means for deriving measures the time-based rate of pressure change in said path.

22. Apparatus comprising:

a system of plural pumps connected with a common fluid flow path;

means for controlling at least two of the pumps to simultaneously inject and withdraw fluid from said path at relative rates which approximately maintain a constant fluid pressure or volume within said path; and

means for measuring at least one relative pump flow calibration factor for said at least two pumps based on the controlled pumping rates required to approximately maintain said constant fluid pressure or volume.

23. Apparatus comprising:

plural pumps connected with a common fluid-containing volume;

means for controlling at least one of said pumps to pump liquid into said volume at a first nominal rate;

means for simultaneously controlling at least one other of said pumps to pump liquid out of said volume at a second nominal rate;

means for monitoring the fluid pressure or volume within said volume during said controlling step; and

means for adjusting at least one of said nominal pump rates in response to said monitored fluid pressure or volume so as to obtain calibrated relative pump flow rates between plural pumps.

24. Apparatus for calibrating, during a preliminary set-up period, anticoagulant pump flow with respect to blood pump flow in a blood constituent processing system, said apparatus comprising:

disposable plastic tubing located in a blood constituent process system which includes a closed fluid flow path between an anticoagulant pump connected to a source of anticoagulant solution and a blood pump connected to a source of saline solution;

means for pumping fluid into said path with one of said pumps at a first predetermined nominal rate and pumping fluid out of said path with the other of said pumps at a second predetermined nominal rate, which rates are initially set to be at assumed equal values;

means for detecting changes in fluid pressure within said path caused by said pumping;

means for adjusting at least one of said first and second rates in response to said detected changes so as to maintain an approximately constant fluid pressure within said path; and

means for deriving a relative pump flow calibration factor based on the controlled nominal flow rates required by said means for adjusting.

25. A method for automatically deriving relative flow calibration data for plural pumps connected with a common fluid path therebetween and a normally open fluid path which establishes fluid communication between the common fluid path and a fluid source, said method comprising:

establishing a closed fluid path which includes said common fluid path by terminating, during a preliminary set-up period, fluid communication between said common fluid path and said fluid source;

automaticallly controlling said pumps, during said preliminary set-up period, to inject fluid into said common fluid path and/or to withdraw fluid from said common fluid path at respectively associated nominal pumping rates;

automatically measuring changes in at least one fluid flow parameter occuring within said closed common fluid path in response to said controlling of said pumps at said respectively associated nominal rates; and

automatically deriving said relative flow calibration data for the individual pumps in response to said measured changes.

26. A method of operating a fluid system of the type having plural pumps connected with a common fluid path therebetween and a normally open fluid path which establishes fluid communication between the common fluid path and a fluid source, said method comprising:

(a) deriving relative flow calibration data for said plural pumps by;

(i) establishing a closed fluid path which includes said common fluid path by terminating, during a preliminary set-up period, fluid communication between said common fluid path and said fluid source;

(ii) automatically controlling said pumps, during said preliminary set-up period, to inject fluid into said common fluid path and/or to wtihdraw fluid from said common fluid path at respectively associated nominal pumping rates;

(iii) automatically measuring changes in at least one fluid flow parameter occuring within said closed common fluid path in response to said controlling of said pumps at said respectively associated nominal rate; and

(iv) automatically deriving said relative flow calibration data for the individual pumps in response to said measured changes; and

then

(b) reestablishing, during a normal operating cycle after said preliminary set-up period, said normally open fluid path and controlling the operating rates of said plural pumps based upon said derived relative flow calibration data.

27. Apparatus for automatically deriving relative flow calibration data of plural pumps connected with a common fluid path therebetween and a normally open fluid path which establishes fluid communication between the common fluid path and a fluid source, said apparatus comprising:

means for establishing a closed fluid path which includes said common fluid path by terminating, during a preliminary set-up period, fluid communication between said common fluid path and said fluid source;

means for automatically controlling said pumps, during said preliminary set-up period, to inject fluid into said common fluid path and/or to withdraw fluid from said common fluid path ar respectively associated nominal pumping rates;

means for automatically measuring changes in at least one fluid flow parameter occurring within said closed common fluid path in response to said controlling of said pumps at said respectively associated nominal rates; and

means for automatically deriving said relative flow calibration data for the individual pumps in response to said measured changes.

28. A method for automatically deriving relative flow calibration data of plural pumps connected with a common fluid path therebetween, said method comprising the steps of:

automatically controlling said pumps to inject fluid into said common fluid path and/or to withdraw from said common fluid path at respectively associated nominal pumping rates;

automatically measuring changes in at least one fluid flow parameter occurring within said common fluid path in response to said controlling step of said pumps at said respectively associated nominal rates;

comparing said measured changes in said at least one flow parameter to a predetermined standard value for said flow parameter;

automatically continually modifying the pumping rate of at least one of said pumps from said nominal pumping rate thereof in response to said measured changes being at variance with said predetermined standard value until said measured changes are comparable to said predetermined standard value; and

automatically deriving relative calibration data representative of said modified pumping rate of said at least one pump relative to said respective nominal rate thereof, whereby calibration data for the individual pumps using said measured changes is obtained.

29. A method for deriving a relative flow calibration data for plural pumps connected with a common fluid path, said method comprising the steps of:

(a) operating said pumps at respective nominal pumping rate such that one pump injects fluid into said path and another pump withdraws fluid from said path;

(b) measuring changes of at least one fluid flow parameter occurring within said common fluid path during said operation of said pumps at said respective nominal pumping rates and determining whether said measured changes are within a predetermined value which is required to maintain an approximately constant fluid pressure in said path while said one pump is injecting fluid into said path and said another pump is withdrawing fluid from said path;

(c) modifying the pumping rate of said one and/or another pumps from said nominal pumping rate thereof until said changes of said at least one fluid flow parameter meausured according to step (b) is within said predetermined value; and

(d) deriving a calibration value for said one and/or another pumps which is representative of said modified pumping rate, whereby calibration data for said pumps is obtained.

30. Apparatus for deriving relative flow calibration data for plural pumps connected with a common fluid path, said apparatus comprising:

means for controlling said pumps to inject fluid into said path and/or to withdraw fluid from said path at respectively associated nominal rates;

means for measuring changes in at least one fluid flow parameter occuring within said path in response to said injection of fluid into and withdrawal of fluid from said common fluid path; and

means for deriving relative flow calibration data for the individual pumps, said means for deriving including;

(i) means for comparing said measured changes in said at least one flow paratmeter to a predetermined standard value for said flow parameter;

(ii) means for automatically continually modifying the pumping rate of at least one of said pumps from said nominal pumping rate thereof in response to said measured changes being at variance with said predetermined standard value until said measured changes are comparable to said predetermined standard value; and

(iii) means for generating a calibration value representative of said modified pumping rate of said at least one pump relative to said respective nominal rate thereof, whereby calibration data for the individual pumps using said measured changes is obtained.