Bio-effecting medical material and device

• US 4,769,013 A
• Filed: 06/04/1986
• Issued: 09/06/1988
• Est. Priority Date: 09/13/1982
• Status: Expired due to Term

• Current Assignee: Hydromer, Inc.
• Original Assignee: Hydromer, Inc.
• Inventors: Lorenz, Donald H., Creasy, Walter S.
• Primary Examiner(s): Apley, Richard J.
• Assistant Examiner(s): Prebilic, Paul
• Application Number:
  US06/870,452
• Time in Patent Office: 825 Days
• Field of Search: 106/18.24, 106/18.25, 106/18.35, 128/132 R, 128/157, 128/156, 424/80, 521/54, 521/159, 604/265, 604/308, 604/359, 604/360, 604/364
• US Class Current: 604/265
• CPC Class Codes: A61L 15/225 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 15/46 Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
• CPC Class Codes: A61L 2300/106 Halogens or compounds thereof, e.g. iodine, chlorite
• CPC Class Codes: A61L 2300/202 with halogen atoms, e.g. triclosan, povidone-iodine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 29/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61M 2025/0056 provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
• CPC Class Codes: A61M 25/0045 multi-layered, e.g. coated coating materials A61L29/08
• CPC Class Codes: C08G 18/10 Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
• CPC Class Codes: C08G 18/62 Polymers of compounds having carbon-to-carbon double bonds
• CPC Class Codes: C08G 18/6283 Polymers of nitrogen containing compounds having carbon-to-carbon double bonds C08G18/6262, C08G18/6266 take precedence
• CPC Class Codes: C08L 75/04 Polyurethanes

Abstract

A medical material comprising a polyurethane complexed with polyvinylpyrrolidone and a bio-effecting agent, such as an anti-bacterial agent, complexed with the polyvinylpyrrolidone. The material is used per se as, for example a foam, and as a coating for medical devices such as, for example, catheters and wound drainage tubes.

Claims

1. A medical material comprising:

an anti-bacterial agent or anti-fungal agent complexed with polyvinylpyrrolidone which has been rendered insoluble in water and body fluids by being complexed with a polyurethane prior to complexing with said agent;

said medical material being capable of releasing said anti-bacterial- or anti-fungal-polyvinylpyrrolidone complexed agent from said polyurethane-polyvinylpyrrolidone complex when said complex is in contact with water or body fluids.

2. An anti-bacterial medical material in accordance with claim 1 in which the anti-bacterial agent is iodine, an iodide, hexachlorophene, griseofulvin, or miconazole nitrate.

3. A material in accordance with claim 1 in which the polyurethane is foamed.

4. An anti-bacterial article comprising:

a substrate,

a coating on the substrate comprising a polyurethane complexed with polyvinylpyrrolidone and an anti-bacterial agent complexed with said polyvinylpyrrolidone.

5. An anti-bacterial article in accordance with claim 4 in which the substrate is selected from the group consisting of polyurethane, a vinyl resin, a polyacrylate, a polycarbonate, a polyester or rubber.

6. A device for treating athlete'"'"'s foot comprising a pad of a polyurethane foam complexed with polyvinylpyrrolidone which is complexed with an anti-bacterial and anti-fungal agent.

7. The device of claim 6 in which the agent is iodine.

8. The device of claim 6 in which the agent is an iodide.

9. The device of claim 6 in which the agent is selected from the group consisting of halides, halogens, hexachlorophene, griseofulvin, and miconazole nitrate.

10. The device of any of claims 6 through 9 in which the pad has opposed concave sides for the reception of toes.

11. A medical material obtained from the process which comprises contacting a polyurethane-polyvinylpyrrolidone foam complex with a bio-effecting agent whereby at least some of the bio-effecting agent forms a complex with the polyvinylpyrrolidone present in the polyurethane-polyvinylpyrrolidone foam complex, said medical material releasing water-soluble polyvinylpyrrolidone-bio-effecting complex when contacted with water or a body fluid.

12. The medical material of claim 11 wherein said bio-effecting agent is selected from the group consisting of anti-bacterial agents, anti-fungal agents, analgesics, antibiotics, anesthetics, odor-enhancers, dyes, adhesives, and lubricants.

13. The medical material of claim 12 wherein said agent is selected from the group consisting of iodine, iodide, hexachlorophene, griseofulvin, miconazole nitrate, tolnaftate, benzocaine, salicyclic acid, retinoic acid, ascorbic acid, 4-chloro-3,5-dimethyl phenol, ampicillin, cephalosporcin C, methicillin, amphotericin, lidocaine, and resorcinol.

14. The medical material of claim 13 wherein said bio-effecting agent is iodine.

15. A medical material obtained from the process which comprises contacting a polyurethane-polyvinylpyrrolidone film complex with a bio-effecting agent whereby at least some of the bio-effecting agent forms a complex with the polyvinylpyrrolidone present in the polyurethane-polyvinylpyrrolidone film complex, said medical material releasing water-soluble polyvinylpyrrolidone-bio-effecting complex when contacted with water or a body fluid.

16. The medical material of claim 15 wherein said bio-effecting agent is selected from the group consisting of anti-bacterial agents, anti-fungal agents, analgesics, antibiotics, anesthetics, odor-enhancers, dyes, adhesives, and lubricants.

17. The medical material of claim 16 wherein said agent is selected from the group consisting of iodine, iodide, hexachlorophene, griseofulvin, miconazole nitrate, retinoic acid, ascorbic acid, 4-chloro-3,5-dimethyl phenol, ampicillin, cephalosporcin C, methicillin, amphotericin, lidocaine, and resorcinol.

18. The medical material of claim 17 wherein said bio-effecting agent is iodine.