Method and apparatus for endoscopic blood flow detection by the use of ultrasonic energy

• US 4,770,185 A
• Filed: 02/11/1986
• Issued: 09/13/1988
• Est. Priority Date: 02/14/1983
• Status: Expired due to Term

• Current Assignee: Board of Regents of The University of Washington (University of Washington)
• Original Assignee: Board of Regents of The University of Washington (University of Washington)
• Inventors: Gilbert, David A., Martin, Roy W., Silverstein, Fred E.
• Primary Examiner(s): Jaworski, Francis J.
• Application Number:
  US06/828,496
• Time in Patent Office: 945 Days
• Field of Search: 128/4, 128/660-661, 128/663, 128/908
• US Class Current: 600/454
• CPC Class Codes: A61B 1/00177 for 90 degrees side-viewing
• CPC Class Codes: A61B 1/018 for receiving instruments
• CPC Class Codes: A61B 1/2736 Gastroscopes
• CPC Class Codes: A61B 17/22 Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for dilators A61M29/00
• CPC Class Codes: A61B 17/3478 Endoscopic needles, e.g. for infusion biopsy needles A61B10/0233; catheters with injection needles A61M25/0067
• CPC Class Codes: A61B 2017/320084 Irrigation sleeves
• CPC Class Codes: A61B 2018/1407 Loop
• CPC Class Codes: A61B 5/489 Blood vessels
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/445 Details of catheter construction

Abstract

A system for endoscopic detection of blood flow is disclosed. A catheter is sized to pass through the biopsy channel of an endoscope and includes an elongated catheter tube of flexible material and an ultrasonic probe carried by the catheter tube adjacent its tip. Depending on the application, the ultrasonic field provided by the ultrasonic probe may be either transverse or parallel to the longitudinal axis of the catheter tube and may be either highly directional, omnidirectional, or sectorial. The ultrasonic probe is coupled to a pulsed Doppler circuit (FIG. 16) by an isolation circuit (FIG. 20) that provides electrical isolation and RFI suppression. The Doppler circuit is designed to enhance close proximity detection of blood flow, to limit the range of the probe'"'"'s ultrasonic field, and to distinguish between arterial blood flow, venous blood flow, and vessel wall motion.

Claims

1. A system for endoscopic detection of blood flow in intracorporeal blood vessels, said system comprising:

(a) a catheter including an elongated tube having a longitudinal axis, said tube being constructed of flexible material and having a tip at one end, a cylindrical ultrasonic probe carried by said tube adjacent its tip, and flexible conductive means electrically connected to said probe and disposed within and extending along the length of said tube, said catheter being sized to pass through the biopsy channel of an endoscope, said proble providing an unfocused, radial ultrasonic field transverse to the longitudinal axis near the tip of said tube;

(b) an isolation circuit means for providing electrical isolation and RFI suppression that is connected to said flexible conductive means; and

,

(c) a Doppler circuit connected to said isolation circuit means, said Doppler circuit including;

a transmitting means and a receiving means coupled to said isolation circuit means, said transmitting means for providing a pulsed, high-frequency electrical signal to said ultrasonic probe that causes said probe to transmit a burst of ultrasonic energy, said receiving means for receiving and amplifying a high-frequency electrical signal produced by said probe as a result of returns of said transmitted burst of ultrasonic energy;

means varying the gain of said receiving means with time, such that, said gain being substantially attenuated during said pulsed, high-frequency electrical signal from said transmitting means, said gain thereafter increasing at a variable rate to compensate for dispersion and attenuation losses of said ultrasonic energy, and said gain being thereafter substantially attenuated at a selectable time corresponding to a desired maximum range from said ultrasonic probe;

means producing a Doppler signal from said received and amplified electrical signal; and

,

means filtering said Doppler signal to provide a filtered Doppler signal, said filtered Doppler signal containing either those frequencies produced by;

primarily venous blood flow;

by venous and arterial blood flow;

or, by primarily arterial blood flow, said filtering means being selectable to produce any one of said filtered Doppler signals.

2. The system of claim 1, wherein the frequency of said pulsed, high-frequency electrical signal from said transmitting means is chosen so as to minimize the power level of said signal.

3. The system of claim 2, wherein said frequency is substantially 8 MHz.

4. The system of claim 3, wherein said filtering means includes a plurality of bandpass filters selectively passing either those frequencies in the range of substantially 200 Hz to substantially 1500 Hz for primarily venous blood flow, or those frequencies in the range of substantially 500 Hz to substantially 5000 Hz for venous and arterial blood flow, or those frequencies in the range of substantially 2000 Hz to substantially 5000 Hz for primarily arterial flow.

5. The system of claim 1, wherein said field is omnidirectional and transverse to the longitudinal axis near the tip of said tube.

6. The system of claim 1, wherein said field is sectorial and transverse to the longitudinal axis near the tip of said tube.

7. The system of claim 1,

wherein said isolation circuit includes:

a transformer having a core, a primary winding on said core, and a secondary winding on said core; and

, means coupling said secondary winding to said Doppler circuit;

wherein the material and structure of said core are chosen to minimize capacitive coupling between said primary and said secondary windings; and

,

wherein said flexible conductive means is connected to said primary winding.

8. The system of claim 1,

wherein said flexible conductive means includes first and second microcoaxial cables;

wherein said isolation circuit includes;

a transformer having a core, a center-tapped primary winding on said core, and a secondary winding on said core; and

, means coupling said secondary winding to said Doppler circuit;

wherein the center conductors of said microcoaxial cables are connected to said ultrasonic probe and to opposing sides of said primary windings;

wherein the outer conductive sheaths of said microcoaxial cables are connected to each other and to the center tap of said primary winding; and

,

wherein the material and structure of said core is chosen to minimize capacitive coupling between said primary and said secondary windings.

9. The system of claim 1,

wherein said isolation circuit includes:

a first transformer having a core, a primary winding on said core, and a secondary winding on said core;

a second transformer having a core, a center-tapped primary winding on said core, and a secondary winding on said core;

first and second shielded cables, the inner conductors of said cables being connected to opposing sides of said secondary winding of said first transformer and to opposing sides of said primary winding of said second transformer, and the sheaths of said cables being connected to each other and to;

the center tap of said primary winding of said second transformer;

one side of said secondary winding of said second transformer; and

, ground; and

, means coupling said secondary winding of said second transformer to said Doppler circuit;

wherein said flexible conductive means is connected to said primary winding of said first transformer; and

,

wherein the materials and structures of said cores of said first and said second transformers are chosen to minimize capacitive coupling between the primary and secondary windings thereof.