Column for removing .beta..sub.2 -microglobulin

• US 4,770,774 A
• Filed: 05/14/1987
• Issued: 09/13/1988
• Est. Priority Date: 09/19/1985
• Status: Expired due to Fees

• Current Assignee: Toray Industries Incorporated
• Original Assignee: Toray Industries Incorporated
• Inventors: Ida, Nobuo, Kataoka, Hiroshi, Kunitomo, Tetsunosuke
• Primary Examiner(s): Schor, Kenneth M.
• Application Number:
  US07/057,968
• Time in Patent Office: 488 Days
• Field of Search: 422/44, 422/45, 422/70, 210/317, 210/646, 210/321.72, 210/638, 210/632, 210/259, 436/518, 436/529, 436/530, 436/531, 436/807
• US Class Current: 210/259
• CPC Class Codes: A61M 1/3679 by absorption A61M1/3675 takes precedence
• CPC Class Codes: A61M 2202/0057 retained by adsorption
• CPC Class Codes: A61M 2202/0421 Beta-2-microglobulin
• CPC Class Codes: B01D 15/00 Separating processes involving the treatment of liquids with solid sorbents using liquid sorbents B01D11/00; ion exchange processes or materials, sorbent materials in general B01J, e.g. sorbents for chromatography B01J20/281; for investigating or analysing materials G01N30/00; Apparatus therefor
• CPC Class Codes: B01D 15/3809 of the antigen-antibody type, e.g. protein A, G, L chromatography
• CPC Class Codes: B01J 20/321 consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
• CPC Class Codes: B01J 20/3212 consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
• CPC Class Codes: B01J 20/3219 involving a particular spacer or linking group, e.g. for attaching an active group
• CPC Class Codes: B01J 20/3274 Proteins, nucleic acids, polysaccharides, antibodies or antigens
• CPC Class Codes: B01J 20/3282 Crosslinked polymers

Abstract

A column comprising an insoluble carrier and an anti-β₂ -microglobulin antibody immobilized to the carrier can specifically adsorb and remove β₂ -microglobulin in the blood. This column is useful for the prevention and treatment of diseases such as carpal tunnel syndrome observed in patients undergoing blood dialysis.

Claims

1. A system for dialyzing blood comprising a blood dialyzer and a column for removing β

₂ -microglobulin including insoluble carrier and an anti β

₂ -microglobulin antibody immobilized to the carrier, which column is connected in series or in parallel to the blood dialyzer.

2. The system of claim 1 wherein the antibody is a monoclonal antibody.