Vitamin D analogues
First Claim
1. Compounds of the general formula:
- ##STR8## wherein R represents a hydrogen atom or a hydroxyl protecting group, Y represents a hydrogen atom, a hydroxyl group or a protected hydroxyl group, X represents the residue of a dienophile and R1 represents a halogen atom, hydroxyl or tosyloxy group or a group of formula;
Z--R3 where Z represents --O--, --S--, --NR4 or --SO--, where R3 represents a straight or branched aliphatic group having 1-12 carbon atoms which may carry one or more substituents selected from halogen atoms, hydroxyl groups and protected hydroxy groups and R4 represents hydrogen or a straight or branched aliphatic group having 1-12 carbon atoms which may carry one or more substituents selected from halogen atoms, hydroxyl groups and protected hydroxy groups and R2 represents a hydrogen atom or R1 and R2 together represent an oxo group.
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Accused Products
Abstract
Compounds of the general formula ##STR1## wherein R represents a hydrogen atom or a hydroxyl protecting group, Y represents a hydrogen atom or an optionally protected hydroxyl group, X represents the residue of a dienophile and either R1 represents a halogen atom a hydrocarbylsulphonyloxy group or a group of the formula --Z--R3 (in which Z represents --O--, --S--, --SO--, --NR4 -- or --CR4 R5 -- and R3, R4 and R5, which may be the same or different, each represent a hydrogen atom or a straight or branched aliphatic group having 1-12 carbon atoms and which may optionally carry one or more substituents) and R2 represents a hydrogen atom or R1 and R2 together represent an oxo group or an optionally substituted alkylidene group, except that R1 and R2 together with the group --CH(CH3)CH-- to which they are attached do not represent a group having the branched 17β-hydrocarbyl side chain skeleton of vitamin D2 or vitamin D3 or use in the preparation of novel vitamin D analogues.
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Citations
5 Claims
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1. Compounds of the general formula:
- ##STR8## wherein R represents a hydrogen atom or a hydroxyl protecting group, Y represents a hydrogen atom, a hydroxyl group or a protected hydroxyl group, X represents the residue of a dienophile and R1 represents a halogen atom, hydroxyl or tosyloxy group or a group of formula;
Z--R3 where Z represents --O--, --S--, --NR4 or --SO--, where R3 represents a straight or branched aliphatic group having 1-12 carbon atoms which may carry one or more substituents selected from halogen atoms, hydroxyl groups and protected hydroxy groups and R4 represents hydrogen or a straight or branched aliphatic group having 1-12 carbon atoms which may carry one or more substituents selected from halogen atoms, hydroxyl groups and protected hydroxy groups and R2 represents a hydrogen atom or R1 and R2 together represent an oxo group. - View Dependent Claims (2, 5)
- ##STR8## wherein R represents a hydrogen atom or a hydroxyl protecting group, Y represents a hydrogen atom, a hydroxyl group or a protected hydroxyl group, X represents the residue of a dienophile and R1 represents a halogen atom, hydroxyl or tosyloxy group or a group of formula;
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3. Compounds of general formula IV or IVa:
- ##STR9## wherein R represents a hydrogen atom or a hydroxyl protecting group, Y represents a hydrogen atom, a hydroxyl group or a protected hydroxyl group, R1 represents a halogen atom, hydroxyl or tosyloxy group or a group of formula;
Z-R3 where Z represents --O--,--S--, --NR4, or --SO--, where R3 represents a straight or branched aliphatic group having 1-12 carbon atoms which may carry one or more substituents selected from halogen atoms, hydroxyl groups and protected hydroxy groups and R4 represents hydrogen or a straight or branched aliphatic group having 1-12 carbon atoms which may carry one or more substituents selected from halogen atoms, hydroxyl groups and protected hydroxy groups and R2 represents a hydrogen atom or R1 and R2 together represent an oxo group. - View Dependent Claims (4)
- ##STR9## wherein R represents a hydrogen atom or a hydroxyl protecting group, Y represents a hydrogen atom, a hydroxyl group or a protected hydroxyl group, R1 represents a halogen atom, hydroxyl or tosyloxy group or a group of formula;
Specification