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Chemically cleavable nucleotides

  • US 4,772,691 A
  • Filed: 06/05/1985
  • Issued: 09/20/1988
  • Est. Priority Date: 06/05/1985
  • Status: Expired due to Fees
First Claim
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1. A compound having the structure:

  • ##STR12## wherein B is selected from purine, 7-deazapurine and pyrimidine provided that when B is purine or 7-deazapurine, it is attached at the N9 -position of purine or deazapurine, and when B is pyrimidine, it is attached at the N1 -position;

    wherein A represents biotin or iminobiotin wherein ...D... is selected from the formulae;

    ##STR13## D is a chemically cleavable disulfide bond and ...D... joins B and A, provided that if B is purine, the linkage is attached to the 8-position of the purine, if B is 7-deazapurine, the linkage is attached to the 7-position of the deazapurine, and if B is pyrimidine, the linkage is attached to the 5-position of the pyrimidine; and

    wherein each of x, y and z represents ##STR14##

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