Programmable dialyzer system analyzer and method of use

• US 4,774,955 A
• Filed: 07/29/1987
• Issued: 10/04/1988
• Est. Priority Date: 06/04/1986
• Status: Expired due to Fees

• Current Assignee: Solutech, Inc.
• Original Assignee: Solutech, Inc.
• Inventors: Jones, Jeffrey S.
• Primary Examiner(s): Cohen, Lee S.
• Application Number:
  US07/079,269
• Time in Patent Office: 433 Days
• Field of Search: 128/632, 128/635, 604/96, 604/167, 422/101, 73/19, 73/863.23
• US Class Current: 600/366
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/07 Endoradiosondes
• CPC Class Codes: A61B 5/14528 invasively
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: B01D 61/28 Apparatus therefor
• CPC Class Codes: G01N 33/491 by separating the blood components G01N15/05 takes precedence

Abstract

An apparatus and a method of use for removing specified dialyzable components from a complex reference fluid such as, for example, blood. The invention includes a semi-permeable tubular dialysis membrane, which is inserted into the reference fluid. An equilibration fluid is injected into the tubular membrane and allowed to equilibrate with the outside reference fluid. The equilibrated fluid is then removed for analysis.

Claims

1. An apparatus for treating a complex fluid comprising:

(a) a dialysis system for recovering dialyzable components from said complex fluid, said dialysis system comprising a body portion including a flexible, elongated tubular semi-permeable dialyzing membrane having a closed distal end and a proximal end, said body portion further including a single lumen within said dialyzing membrane, a wire stylet within said lumen for maintaining the longitudinal integrity of said body portion, and fluid communication means adapted to pass a membrane solution to and from said body portion;

(b) means for analyzing the content and quantity of said dialyzable components;

(c) programmable means for processing said analyzed information generated from step (b); and

(d) means for delivering a controlled amount of an injection dose to said complex fluid in accordance with the result of said processing from said programmable means of step (c).

2. The apparatus according to claim 1, wherein said means for delivering said controlled amount of injection dose is an infusion pump.

3. The apparatus according to claim 1, further comprising means for delivering said injection dose to said body portion lumen wherein said semi-permeable dialyzing membrane of said lumen is permeable to said injection dose, allowing said injection dose to pass through said semi-permeable membrane to said complex fluid.

4. The apparatus according to claim 1 wherein said fluid communication means comprises a tubular conduit having a lumen along the longitudinal axis of said conduit, said conduit having a first and a second end, wherein said first end of said conduit is attached to the proximal end of said body portion such that the lumens of each of said body portion and said conduit communicate directly with each other.

5. A method for treating a complex fluid comprising:

(a) placing a dialysis apparatus into said fluid, said apparatus comprising a body portion including an elongated tubular dialyzing membrane having a closed distal end and a proximal end, said body portion further including a single lumen within said tubular dialyzing membrane, means within said lumen for maintaining the longitudinal integrity of said body portion, an elongated tubular conduit having a lumen along the longitudinal axis of said conduit, said conduit having a first end and a second end wherein said first end of said conduit is attached to said proximal end of said body portion such that the lumens of each of said body portion and said conduit communicate directly with each other, and said conduit being adapted to receive a means for injecting and withdrawing a membrane solution into said body portion lumen in such a manner that said injecting means is in adjacent and direct communication with said body portion lumen;

(b) injecting a membrane solution through said conduit into said lumen of said tubular membrane, said membrane solution being adapted to equilibrate with said complex fluid;

(c) analyzing said equilibrated membrane solution; and

(d) delivering a controlled amount of an injection dose to said complex fluid in accordance with the result of said analyzing.

6. An apparatus for treating a complex fluid comprising:

(a) a dialysis system for recovering dialyzable components from said complex fluid, said dialysis system comprising a body portion including a flexible, elongated tubular semi-permeable dialyzing membrane having a closed distal end and a proximal end, said body portion further including a single lumen within said dialyzing membrane, means within said lumen for maintaining the longitudinal integrity of said body portion, and fluid communication means adapted to pass a membrane solution to and from said body portion;

(b) means for analyzing the content and quantity of said dialyzable components;

(c) programmable means for processing said analyzed information generated from step (b); and

(d) means for delivering a controlled amount of an injection dose to said body portion lumen in accordance with the result of said processing from said programmable means of step (c), wherein said semi-permeable membrane is permeable to said injection dose allowing said injection dose to pass through said semi-permeable membrane to said complex fluid.

7. The apparatus according to claim 6, wherein said means for delivering said controlled amount of injection dose is an infusion pump.

8. A method for treating a complex fluid comprising:

(a) placing a dialysis apparatus into said fluid, said apparatus comprising a body portion including an elongated tubular dialyzing membrane having a closed distal end and a proximal end, said body portion further including a single lumen within said tubular dialyzable membrane, means within said lumen for maintaining the longitudinal integrity of said body portion, an elongated tubular conduit having a lumen along the longitudinal axis of said conduit, said conduit having a first end and a second end wherein said first end of said conduit is attached of said proximal end of said body portion such that the lumens of each of said body portion and said conduit communicate directly with each other, and said conduit being adapted to receive a means for injecting and withdrawing a membrane solution into said body portion lumen in such a manner that said injecting means is in adjacent and direct communication with said body portion lumen;

(b) injecting a membrane solution through said conduit into said lumen of said tubular membrane, said membrane solution being adapted to equilibrate with said complex fluid;

(c) analyzing said equilibrated membrane solution; and

(d) delivering a controlled amount of an injection dose through said tubular dialyzing membrane to said complex fluid in accordance with the result of said analyzing.