Method and apparatus for mammalian nerve regeneration
First Claim
1. An apparatus for in vivo regeneration of a damaged mammalian nerve having proximal and distal nerve ends comprising alignment means extending over said proximal and distal nerve ends for maintaining the nerve ends in proximity to each other and means coupled to said alignment means adapted for applying an electric potential gradient between the proximal nerve end and the distal nerve end at a level, direction and for a period of time to produce nerve regeneration.
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Abstract
The invention relates to method and apparatus for in vivo mammalian nerve regeneration of a damaged nerve using an electric current through the damaged nerve while the nerve ends are abutted against one another, sutured together or spaced apart from each other. The apparatus is implantable in a human body so that the electric current can be maintained for an extended period of time to produce regeneration of the damaged nerve.
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Citations
13 Claims
- 1. An apparatus for in vivo regeneration of a damaged mammalian nerve having proximal and distal nerve ends comprising alignment means extending over said proximal and distal nerve ends for maintaining the nerve ends in proximity to each other and means coupled to said alignment means adapted for applying an electric potential gradient between the proximal nerve end and the distal nerve end at a level, direction and for a period of time to produce nerve regeneration.
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4. An appartus at least partially implantable in a human body for regenerating a damaged nerve having proximal and distal nerve ends comprising nerve guide means adapted to extend over said proximal and distal nerve ends for maintaining said nerve ends in juxtaposition with one another, and means coupled to said nerve guide means adapted for applying an electric potential gradient between the nerve ends with a higher potential at the proximal nerve end and a lower potential at the distal nerve end for a time and at a level to produce nerve regeneration.
- 5. An apparatus for in vivo regeneration of a damaged mammalian nerve having proximal and distal nerve ends comprising a nerve guide means adapted to extend over said proximal and distal nerve ends for maintaining said nerve ends in juxtaposition with one another and means coupled to said nerve guide means adapted for applying a potential gradient between the nerve ends at a level below the threshold for establishing action potential in said nerve and in a direction and for a time to produce nerve regeneration.
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7. An apparatus for regenerating a damaged nerve having proximal and distal nerve ends comprising nerve guide means implantable in the human body and extending over said proximal and distal nerve ends for maintaining said nerve ends in juxtaposition with one another, and means coupled to said nerve guide means for establishing an electric potential gradient between the nerve ends with a higher potential at the proximal nerve end relative to the distal nerve end and at a level below the threshold for establishing action potential in the nerve and for a time sufficient to produce regeneration of the damaged nerve.
- 8. A method of in vivo regeneration of a damaged mammalian nerve having proximal and distal nerve ends comprising bringing said proximal and distal nerve ends into proximity with each other and thereafter establishing an electric potential gradient between the proximal nerve end and the distal nerve end at a level and for a period of time to produce nerve regeneration.
- 11. A method of mammalian nerve regeneration of a damaged nerve having proximal and distal nerve ends comprising implanting a nerve guide means over the proximal and distal nerve ends to maintain said nerve ends in juxtaposition with one another and applying an electric potential gradient between said proximal nerve end and said distal nerve end with the electric potential being higher at the proximal nerve end, said potential gradient being below the threshold for establishing action potential in the nerve, and being applied for a period of time necessary to produce nerve regeneration.
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13. A method of in vivo regeneration of a damaged mammalian nerve having proximal and distal nerve ends comprising positioning a nerve guide means proximate the damaged nerve to bring said proximal and distal nerve ends into proximity with each other, suturing said proximal and distal nerve ends together and thereafter applying an electric potential gradient between the proximal nerve end and the distal nerve end at a level and for a period of time to produce nerve regeneration
Specification