Luminescent layers for use in apparatus for determining the oxygen concentration in gases and the like

• US 4,775,514 A
• Filed: 04/23/1986
• Issued: 10/04/1988
• Est. Priority Date: 06/09/1983
• Status: Expired due to Term

• Current Assignee: GlukoMediTech AG (Sangui Biotech, Incorporated)
• Original Assignee: Oswald Burkhard, Wolfgang Barnikol
• Inventors: Barnikol, Wolfgang, Burkhard, Oswald
• Primary Examiner(s): Marcus, Michael S.
• Application Number:
  US06/854,901
• Time in Patent Office: 895 Days
• Field of Search: 422/52, 422/55, 422/68, 422/83, 422/88, 422/91, 436/136, 436/138, 436/164, 436/172, 250/458.1, 250/459.1, 128/633, 128/634
• US Class Current: 422/82.08
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: C07K 14/805 Haemoglobins; Myoglobins
• CPC Class Codes: G01N 2021/7786 Fluorescence
• CPC Class Codes: G01N 21/6428 Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" in vivo A61B5/00; immunoassay G01N33/53
• CPC Class Codes: Y10T 436/207497 Molecular oxygen

Abstract

A luminescent layer for use in apparatus for determining the oxygen concentration in gases, fluids and tissues by measuring the decrease in the light emission of a luminescent surface irradiated with an excitation light of a certain wavelength, where the luminescent dye forms a homogeneous mixture with the light-transparent layer substance, in which case the surface may also have a fine-grained structure.

Claims

1. A luminescent layer for use in apparatus for determining the oxygen concentration in gases, fluids and tissues by measuring the decrease of the luminescence in the light emission of a luminescent surface irradiated with an excitation light of a certain wavelength, wherein the luminescent layer consists essentially of an homogeneous mixture of a luminescent dye and an hydrophobic light transparent layer substance.

2. A luminescent layer according to claim 1, wherein silicone caoutchouc is used as the layer substance.

3. A luminescent layer according to claim 2, further including a substrate, said substrate having a fine grained surface for supporting said luminescent layer.

4. A luminescent layer according to claim 1, further including a substrate, said substrate having a fine-grained surface for supporting said luminescent layer.

5. A luminescent layer according to claim 4, wherein the grain size of the fine-grained surface is smaller than 1 mm.

6. A luminescent layer according to claim 1, wherein the luminescent dye is fluorescent yellow.

7. A luminescent layer according to claim 6, werein about 10 mg of fluorescent yellow is present to about 1.4 ml of layer solution.

8. A luminescent layer according to claim 1, wherein the luminescent dye is pyrene.

9. A luminescent layer according to claim 1, wherein the luminescent dye is coronene.

10. A luminescent layer according to claim 1, wherein the luminescent dye is a cyano derivative of benzene.