Hematology control or calibrator with red cell components of enhanced stability
First Claim
1. A hematology control or calibrator comprising a suspension of treated erythrocytes in a stabilizing medium, characterized by the treated erythrocytes having been exposed to a aliphatic unsaturated aldehyde of 3-6 carbons under conditions sufficient to increase the stability of the treated erythrocytes in the stabilizing medium without impairing the ability of a lysing reagent to lyse the treated erythrocytes in a hematology analyzer.
4 Assignments
0 Petitions
Accused Products
Abstract
Red cells are exposed to an unsaturated aldehyde such as acrolein (propenal) under conditions sufficient to increase the stability of the cells without impairing the ability of a lysing reagent to lyse the cells. After treatment, the treated cells are washed and are suspended in a stabilizing suspension medium.
-
Citations
10 Claims
- 1. A hematology control or calibrator comprising a suspension of treated erythrocytes in a stabilizing medium, characterized by the treated erythrocytes having been exposed to a aliphatic unsaturated aldehyde of 3-6 carbons under conditions sufficient to increase the stability of the treated erythrocytes in the stabilizing medium without impairing the ability of a lysing reagent to lyse the treated erythrocytes in a hematology analyzer.
-
6. A process for preparing a hematology control or calibrator comprising the steps:
-
(a) exposing washed erythrocytes to an unsaturated aldehyde at a treatment concentration and temperature for a treatment time period, (b) after the treatment time period, washing the treated erythrocytes, and (c) suspending the treated and washed erythrocytes in a stabilizing suspending medium the treatment concentration, temperature and time being sufficient to increase the stability of the treated erythrocytes in suspending medium without impairing the ability of a lysing reagent to lyse the treated erythrocytes in a hematology analyzer. - View Dependent Claims (7, 8, 9, 10)
-
Specification