Method and apparatus for the assessment of autonomic response by broad-band excitation
First Claim
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1. Method for assessing autonomic response comprising:
- applying a broad-band perturbation to a physiologic input signal sensed by the autonomic nervous system;
monitoring a physiologic output signal modulated by the autonomic nervous system;
computing the transfer relation between the physiologic input and output signals; and
displaying said transfer relation.
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Abstract
A rapid, noninvasive technique for quantifying the dynamic response of the autonomic nervous system (ANS) to perturbations it senses over a broad range of physiologically relevant frequencies. The technique involves two steps. First, a physiologic parameter sensed by the ANS is subjected to a broad-band perturbation as an input signal while a physiologic parameter modulated by the ANS is monitored as an output signal. Then, the transfer relation between input signal and output signal is determined. The computed transfer relation is then readily interpretable in terms of responsiveness of the various limbs of the ANS.
111 Citations
33 Claims
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1. Method for assessing autonomic response comprising:
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applying a broad-band perturbation to a physiologic input signal sensed by the autonomic nervous system; monitoring a physiologic output signal modulated by the autonomic nervous system; computing the transfer relation between the physiologic input and output signals; and
displaying said transfer relation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. Method for assessing autonomic response comprising:
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applying a broad-band perturbation to respiratory activity which is the input signal sensed by the autonomic nervous system; monitoring heart rate as the output signal modulated by the autonomic nervous system; computing the transfer relation between respiratory activity and heart rate; and
displaying said transfer relation.
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24. Method for assessing autonomic response comprising:
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applying a broad-band perturbation to a physiologic parameter which is the input signal sensed by the autonomic nervous system; monitoring an output signal which is a physiologic parameter which is modulated by the autonomic nervous system characterizing the relationship between the input and output signals; and
displaying said transfer relation. - View Dependent Claims (25)
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26. Apparatus for assessing autonomic response comprising:
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means for subjecting a physiologic parameter sensed by the autonomic system as an input signal to a broad-band perturbation; means for monitoring an output signal which is a physiologic parameter modulated by the autonomic nervous system; and means for computing the relationship between the input and output signals; and
means for displaying said transfer relation. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33)
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Specification