Ultrasonically modulated polymeric devices for delivering compositions

• US 4,779,806 A
• Filed: 11/28/1986
• Issued: 10/25/1988
• Est. Priority Date: 07/23/1984
• Status: Expired due to Term

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Kost, Joseph, Langer, Robert S.
• Primary Examiner(s): Rosenbaum, Mark
• Application Number:
  US06/936,000
• Time in Patent Office: 697 Days
• Field of Search: 128/24 A, 604/891, 604/22, 604/49, 604/290, 604/36, 604/306, 241/1, 241/301, 241/2, 241/14, 241/30, 53/492, 53/900, 222/1
• US Class Current: 241/1
• CPC Class Codes: A61K 41/0047 Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/2027 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61K 9/2031 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
• CPC Class Codes: C08G 67/04 Polyanhydrides

Abstract

A composition such as a biologically active substance is delivered upon demand from a polymeric matrix by exposing the polymeric matrix containing the composition to ultrasonic energy.

Claims

1. A process for delivering a composition on demand which comprises:

incorporating said composition within a polymeric matrix,

surrounding said composition and polymeric matrix with a liquid medium, and

exposing said polymeric matrix to ultrasonic energy for a predetermined time and at a frequency to effect cavitation of said polymeric matrix to release said composition from said matrix in a controlled manner over a specific time period.

2. The process of claim 1 wherein the composition is a fragrance.

3. The process of claim 1 wherein said composition is a pheromone.