Controlled release drug delivery system for the periodontal pocket

• US 4,780,320 A
• Filed: 04/29/1986
• Issued: 10/25/1988
• Est. Priority Date: 04/29/1986
• Status: Expired due to Fees

• Current Assignee: Technical Chemicals And Products, Inc.
• Original Assignee: Pharmetrix Corporation
• Inventors: Baker, Richard W.
• Primary Examiner(s): Swisher, Nancy A. B.
• Application Number:
  US06/856,961
• Time in Patent Office: 910 Days
• Field of Search: 424/493, 424/489, 424/484, 424/490, 424/486, 424/497
• US Class Current: 424/493
• CPC Class Codes: A61K 6/17 Particle size
• CPC Class Codes: A61K 6/30 Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
• CPC Class Codes: A61K 6/69 Medicaments
• CPC Class Codes: A61K 9/0063 Periodont
• CPC Class Codes: A61K 9/1641 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
• CPC Class Codes: A61K 9/1647 Polyesters, e.g. poly(lactide-co-glycolide)
• CPC Class Codes: A61K 9/1652 Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin homeopathic globules A61K9/1623
• CPC Class Codes: C08L 1/286 substituted with acid radicals, e.g. carboxymethyl cellulose [CMC] C08L1/282 takes precedence

Abstract

A controlled release drug delivery system for placement in the periodontal pocket. The system comprises a plurality of drug-containing microparticles or microcapsules, between 10 and 500 microns in size, suspended in a pharmaceutically acceptable carrier medium, and is capable of maintaining an effective level of drug in the periodontal pocket for a period of 1 to 30 days.

Claims

1. A controlled release drug delivery system for placement in a periodontal pocket, comprising:

(a) a plurality of discrete microparticles comprising a drug-containing polymer and the drug contained therein, said microparticles being between 10 and 500 microns in diameter, and

(b) a fluid suspending medium for said microparticles;

said drug delivery system remaining active in the periodontal pocket for a period of between one and 30 days.

2. The delivery system of claim 1, wherein the drug is selected from the group consisting of antimicrobial drugs, anti-inflammatory drugs and local anaesthetics.

3. The delivery system of claim 1, wherein the drug is an antibiotic.

4. The delivery system of claim 1, wherein the drug is chosen from the group consisting of tetracycline, its compounds and derivatives.

5. The delivery system of claim 1, wherein the drug is chosen from the group consisting of chlorhexidine, its compounds and derivatives.

6. The delivery system of claim 1, wherein the drug is flurbiprofen.

7. The delivery system of claim 1, wherein said drug-containing polymer is chosen from the group consisting of cellulose acetate, ethylcellulose, polystyrene, polysulfone, polycarbonate and lacticglycolic acid copolymers.

8. The delivery system of claim 1, wherein said drug-containing polymer is polycarbonate.

9. The delivery system of claim 1, wherein said drug-containing polymer is chosen from the group consisting of lacticglycolic acid copolymers.

10. The delivery system of claim 1, wherein the fluid suspending medium has a viscosity of at least 1000 centipoise.

11. The delivery system of claim 1, wherein the fluid suspending medium is a thermally gelling fluid, said fluid having a sol/gel transition temperature between 25°

and 40°

C. and being a free-flowing liquid below the transition temperature and a thickened non-flowing gel above the transition temperature.

12. A method for treating periodontal disease comprising inserting into a periodontal pocket a controlled release drug delivery system comprising:

(a) a plurality of discrete microparticles comprising a drug-containing polymer and the drug contained therein, said microparticles being between 10 and 500 microns in diameter, and

(b) a fluid suspending medium for said microparticles;

said drug delivery system remaining active in the periodontal pocket for a period of between one and 30 days.