Container system with integral second substance storing and dispensing means

• US 4,781,679 A
• Filed: 06/12/1986
• Issued: 11/01/1988
• Est. Priority Date: 06/12/1986
• Status: Expired due to Fees

• Current Assignee: Abbott Laboratories North Chicago IL
• Original Assignee: Abbott Laboratories
• Inventors: Larkin, Mark E.
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): Polutta, Mark O.
• Application Number:
  US06/873,665
• Time in Patent Office: 873 Days
• Field of Search: 604/82-92, 604/414-416, 604/413
• US Class Current: 604/88
• CPC Class Codes: A61J 1/10 Bag-type containers
• CPC Class Codes: A61J 1/1462 Containers with provisions for hanging, e.g. integral adaptations of the container accessories for hanging the container A61M5/1414
• CPC Class Codes: A61J 1/1475 Inlet or outlet ports
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2013 having two piercing ends
• CPC Class Codes: A61J 1/2089 Containers or vials which are to be joined to each other in order to mix their contents combinations of vial and syringe for mixing their contents A61J1/2096
• CPC Class Codes: A61J 1/2093 Containers having several compartments for products to be mixed

Abstract

The invention is an integral container system designed for separately storing a liquid, such as a diluent, and a second substance, such as a medicament, and subsequently adding the second substance to the liquid in a simple and sterile operation. In one embodiment, a flexible I.V. bag is provided with a second substance dispensing cup containing a powdered medicament, which cup fits slidably in a sleeve passing through the walls of the bag. Fitted in the open end of the cup is a pierceable plunger. A hollow needle is held in position to pierce the plunger when the cup is pushed toward the needle. The needle is slidably held so that when it is pushed by the plunger, it will also pierce a diaphragm fitting over the sleeve. When both the plunger and the diaphragm are pierced, fluid access between the cup and the bag is had through the hollow needle. Diluent can then be injected into the cup to dissolve or slurry the powdered medicament. When the cup is pushed further toward the bag, the plunger is stopped and the medicament is expelled from the cup as the volume is reduced.

Claims

1. A container system for separately storing a liquid and a second substance and subsequently dispensing a mixture of the two substances comprising:

container means for containing and delivering a liquid, said container means having walls defining an internal cavity;

sleeve means mounted in a wall of said container, said sleeve means having a pierceable member closing one end thereof;

cup means for containing the second substance, said cup means being slideably positioned in said sleeve means, said cup means having an open end;

pierceable plunger means slideably positioned within said open end of said cup means;

collapsible cap means positioned over the other end of said sleeve means, and over said cup means; and

hollow piercing means disposed between said pierceable plunger and said pierceable member;

whereby as said cup means is urged toward said pierceable member by collapsing said cap means, said piercing means will pierce both said plunger means and said pierceable member, and said plunger means will be forced inwardly of said cup means so as to force said second material from said cup means through said hollow piercing means into said container means.

2. The container system of claim 1 wherein said container is a flexible I.V. bag.

3. The container system of claim 1 wherein said collapsible cap means is positioned at the top of the container and includes a hanging means from which the container system may be suspended during use.

4. The container system of claim 1 wherein said piercing means is in the form of a hollow pin and wherein said cup means is disposed initially at the other end of said sleeve whereby slideable displacement of said cup means toward said pierceable member will force said pin to pierce both said plunger pierceable portion and said pierceable member whereby to establish a path between said cup means and said container means through said hollow pin.

5. The container system of claim 4 wherein said sleeve includes an upstanding coaxial cylindrical post, a portion of said pin being supported by said post.

6. The container system as recited in claim 1 wherein said sleeve means includes a diaphragm sealingly closing said one end of said sleeve means, and said pierceable member comprises a reduced thickness portion of said diaphragm.

7. The container system as recited in claim 1 wherein said plunger means includes a tubular recess, at least a portion of said piercing means being supported within said tubular recess.

8. The container system as recited in claim 7 wherein said plunger means includes a pierceable portion within said tubular recess.

9. A container system for separately storing a liquid and a second substance and subsequently dispensing the second substance into the liquid comprising:

container means for containing and delivering a liquid having wall means defining an internal cavity;

sleeve means passing through the wall means having a first closed pierceable and extending into said internal cavity, and a second end disposed outside of the container;

cup means for containing a quantity of the second substance, said cup means being closed at one end and open at the other end, said open end fitting snugly and slideably within said second end of said sleeve means;

collapsible cap means sealingly closing said second end of said sleeve and thereby enclosing said cup means within said cap means and sleeve means;

plunger means fitting snugly and slideably within the open end of the cup means, and having a pierceable portion; and

hollow piercing means positioned such that, when the cup means is pushed into the sleeve toward said first end of said sleeve and the plunger means is thereby pushed in the same direction, said piercing means pierces both said pierceable portion and said pierceable end thereby providing fluid access between said container means and the cup means.

10. The container system of claim 9 wherein said container is a flexible I.V. bag.

11. The container system of claim 9 wherein said collapsible cap means is provided with hanging means from which the container system may be suspended during use.

12. The container system of claim 11 wherein the hanging means is configured so as to be operable only after the second substance has been dispensed into the liquid.

13. The container system of claim 9 wherein the cup means is comprised of glass and the plunger means is comprised of rubber.

14. The container system of claim 9 wherein

said hollow piercing means comprises a hollow pin;

and

said first pierceable end includes a pierceable diaphragm and guiding means for slideably supporting said hollow pin whereby when said hollow pin is pushed by the plunger means within said guiding means toward the first end of the sleeve means, it pierces said pierceable end of said sleeve means thereby providing fluid access between the hollow pin and the internal cavity.

15. The container system of claim 14 wherein said container is a flexible I.V. bag.

16. The container system of claim 14 wherein the cup means is comprised of glass and the plunger means is comprised of rubber.

17. An I.V. bag system for separately storing a medicament and a diluent and for subsequently mixing the medicament with the diluent prior to delivery, said system comprising:

a container for storing the diluent and for delivery of the mixed diluent and medicament, said container having wall means defining an internal cavity;

sleeve means passing through the wall means whereby a first pierceable end of the sleeve means communicates with the internal cavity and the second end is disposed outside of said container;

cup means for containing a quantity of the medicament, said cup means being closed at one end and open at the other end, said open end fitting snugly and slideably within the second end of the sleeve means;

plunger means fitting snugly and slideably within the open end of the cup means, and having a pierceable portion;

a hollow pin with a first sharp end disposed such that, when the cup means is pushed into the sleeve means toward said first end of said sleeve means and the plunger means is thereby pushed in the same direction, said first sharp end pierces said pierceable portion thereby providing fluid access between the hollow pin and the cup means;

a pierceable diaphragm positioned at said first end of said sleeve means, and guiding means in said sleeve means for slideably holding said hollow pin whereby when the hollow pin is pushed by the plunger means within said guiding means toward the first end of the sleeve means, a second sharp end thereon pierces the diaphragm of said sleeve means thereby providing fluid access between the hollow pin and the internal cavity.

18. The I.V. bag system of claim 17 wherein said container is a flexible I.V. bag.

19. The I.V. bag system of claim 17 further comprising a collapsible cap means positioned over said cup means.

20. The I.V. bag system of claim 19 wherein said sleeve means is positioned at the top of the container and wherein a hanging means from which the I.V. bag system may be suspended during use is provided on said cap means.

21. The I.V. bag system of claim 20 wherein the hanging means is configured so as to be operable only after the medicament has been dispensed into the diluent.

22. The I.V. bag system of claim 17 wherein the cup means is comprised of glass and the plunger means is comprised of rubber.