Single-use, self-annulling injection syringe

• US 4,781,683 A
• Filed: 04/22/1987
• Issued: 11/01/1988
• Est. Priority Date: 04/22/1987
• Status: Expired due to Term

• Current Assignee: Johns Hopkins University of Baltimore Maryland
• Original Assignee: Johns Hopkins University
• Inventors: Leong, Kam, Wozniak, John J.
• Primary Examiner(s): Truluck, Dalton L.
• Assistant Examiner(s): Whelton, Denise
• Application Number:
  US07/041,036
• Time in Patent Office: 559 Days
• Field of Search: 604/187, 604/190, 604/218, 604/236, 604/238, 604/110, 604/319-321, 604/212, 604/215, 137/197, 137/199, 128/765
• US Class Current: 604/110
• CPC Class Codes: A61M 2005/506 Plug actuated by contact with fluid, e.g. hydrophilic expansion plug
• CPC Class Codes: A61M 5/348 snap lock, i.e. upon axial displacement of needle assembly A61M5/344 takes precedence
• CPC Class Codes: A61M 5/5013 Means for blocking the piston or the fluid passageway to prevent illegal refilling of a syringe

Abstract

A single-use, self-annulling syringe is disclosed that is rendered inoperative after a single use without requiring any deliberate action on the part of a user. The injection device uses a hydrophilic expansion plug positioned in the outlet flow channel of the syringe, which expands a short time after being exposed to a drug containing water, thereby rendering the syringe inoperative.

Claims

1. A single use injection device, comprising:

a variable volume chamber adapted to receive a drug containing water;

an injection needle having an internal lumen, said injection needle connected to said variable volume chamber forming a flow channel between said variable volume chamber and said internal lumen of said injection needle; and

a hydrophilic expansion means composed essentially of a hydrogel, positioned within said flow channel, for expanding and blocking said flow channel after being exposed to said drug containing water, thereby preventing reuse of the injection device, wherein said hydrophilic expansion means comprises a delay means for providing a preset time window greater than thirty seconds from the time of exposure of said hydrophilic expansion means to said drug containing water for injection of the drug before the hydrophilic expansion means blocks said flow channel.

2. The injection device of claim 1 wherein said variable volume chamber comprises a hollow syringe barrel and a plunger reciprocally mounted within said hollow syringe barrel, said hollow syringe barrel includes an integral tip portion having an internal channel for fixedly connecting said injection needle to said syringe barrel and for providing said flow channel between said syringe barrel and said internal lumen of said injection needle, said hydrophilic expansion means being positioned within said internal channel.

3. The injection device of claim 2, further comprising a step means formed within said internal channel for securing said hydrophilic expansion means within said flow channel.

4. The injection device of claim 2, wherein said hydrophilic expansion means is a polymeric material that is hydrophilic.

5. The injection device of claim 4, wherein said polymeric material is selected from one of:

poly(vinyl alcohol)

poly(ethylene oxide)

poly(acrylamide)

poly(N-vinyl pyrrolidone)

poly(2-hydroxyethyl methacrylate)

methyl cellulose.

6. The injection device of claim 5, wherein said polymeric material is cross-linked.

7. The injection device of claim 2, wherein a lyophilized drug is positioned within said syringe barrel.

8. The injection device of claim 2, wherein a liquid drug is positioned in said syringe barrel and a membrane is positioned across said syringe barrel to separate said liquid drug from said hydrophilic expansion means.

9. The injection device of claim 1, wherein said variable volume chamber comprises a hollow syringe barrel and a plunger reciprocally mounted within said hollow syringe barrel, and wherein said injection device further comprises a connecting means for coupling said injection needle to said syringe barrel, said connecting means comprises:

a first portion integral to said syringe barrel and forming one end of said syringe barrel; and

,

a second portion fixedly attached to said injection needle and adapted to mate with said first portion, said first and second portions having an internal channel, said hydrophilic expansion means being positioned within said internal channel of said second portion.

10. A single-use injection device comprising:

a hollow syringe barrel integrally coupled at one end to a narrowed portion having an internal flow channel;

a plunger reciprocally mounted within said hollow syringe barrel;

an injection needle having an internal lumen and fixedly mounted into said internal channel; and

,

a hydrophilic expansion means, composed essentially of a hydrogel and positioned within said internal channel, for expanding and blocking said internal channel after being exposed to a drug containing water, thereby preventing reuse of the injection device, wherein said hydrophilic expansion means comprises a delay means for providing a preset time window greater than thirty seconds from the time of exposure of said hydrophilic expansion means to said drug containing water for injection of the drug before the hydrophilic expansion means blocks said internal channel.

11. The injection device of claim 10, further comprising a step projected normal to the axis of said internal channel for securing said hydrophilic expansion means in said internal channel.

12. A single-use injection needle apparatus adapted to couple to the tip portion of a hypodermic syringe, comprising:

a coupling member adapted to couple to the tip portion of a hypodermic needle, said coupling member having an interior flow channel;

a needle having an internal lumen fixedly mounted to one end of said coupling member so that said internal lumen is in fluid communication with said interior flow channel; and

a hydrophilic expansion means composed essentially of a hydrogel, positioned within said interior flow channel, for expanding and blocking said flow channel after being exposed to a drug containing water, thereby preventing reuse of the injection needle apparatus, wherein said hydrophilic expansion means comprises a delay means for providing a preset time window greater than thirty seconds from the time of exposure of said hydrophilic expansion means to said drug containing water for injection of the drug before the hydrophilic expansion means blocks said flow channel.

13. The injection needle apparatus of claim 12, further comprising a step projected normal to the axis of said interior flow channel for securing said hydrophilic expansion means in said flow channel.

14. The injection needle of claim 12, wherein said hydrophilic expansion means is a polymeric material that is hydrophilic.

15. The injection device of claim 14, wherein said polymeric material is selected from one of:

poly(vinyl alcohol)

poly(ethylene oxide)

poly(acrylamide)

poly(N-vinyl pyrrolidone)

poly(2-hydroxyethyl methacrylate)

methyl cellulose.

16. The injection device of claim 15, wherein said polymeric material is cross-linked.