Implantable drug-dispensing capsule and system facilitating its use

• US 4,781,685 A
• Filed: 04/09/1987
• Issued: 11/01/1988
• Est. Priority Date: 04/16/1986
• Status: Expired due to Fees

• Current Assignee: Celsa Composants Electriques, R D M Medical
• Original Assignee: Celsa Composants Electriques, R D M Medical
• Inventors: Meunier, Jean-Francois, Metais, Joel, Lehmann, Gerard, Gautier, Jean-Philippe
• Primary Examiner(s): Wayner, William E.
• Application Number:
  US07/036,228
• Time in Patent Office: 572 Days
• Field of Search: 128/734, 128/630, 604/175, 604/117
• US Class Current: 604/117
• CPC Class Codes: A61M 2039/0238 having means for locating the implanted device to insure proper injection, e.g. radio-emitter, protuberances, radio-opaque markers
• CPC Class Codes: A61M 39/0208 Subcutaneous access sites for injecting or removing fluids transcutaneous access sites A61M39/0247; implantable infusion devices A61M5/14276

Abstract

The invention concerns an implantable drug-dispensing capsule and a process and system facilitating its use. According to the invention, a mechanism (7) for detecting the proximity of the injection needle (1) is provided inside the body (5) of the capsule (3), which detection mechanism is connected to an external signaling device (32) which signals when this proximity is realized.

The invention is in particular applicable to the injection of various drugs in localized sites.

Claims

1. A system for registering proper introduction of an injection syringe needle into the body of a drug-dispensing capsule implantable under the skin of a patient, said capsule, placed in contact by its outer wall with the patient'"'"'s body, including an electrically conducting inner wall forming a mechanism for detecting the proximity of the tip of said needle, and said system being equipped with an external signaling device connected to said inner wall and responding to the state of closure through the patient'"'"'s body of an electrical circuit including said inner conducting wall of the capsule and said needle, the improvement comprising:

an AC generator the input of which is connected to the positive pole of a DC source,

an assembly including a rectifier and filter, said assembly being connected

by a first input terminal to the output of said generator,

by a second terminal to the negative pole of said source,

at least one comparator connected

by lead-out to said signaling device,

by lead-in to a third output terminal of the rectifier/filter assembly and to a comparison unit intended to provide a reference voltage, said comparator being subjected to the difference in voltage between that delivered by said rectifier/filter assembly and that delivered by said comparison unit and being fed, with said signaling device, by said DC source,

a surface electrode placed on a patient'"'"'s skin, said electrode being connected to the negative pole of the source and, in the circuit'"'"'s closed state, in series with said needle, the patient'"'"'s body, and/or said inner wall of the capsule, towards the input terminal of said rectifier/filter assembly.

2. The system according to claim 1, wherein the rectifier/filter assembly further includes:

a current-rectifying component such as a diode placed on the feed line joining the input terminal and the output terminal of the assembly,

a condenser connected both to said feed line at the site of the cathode of said diode and to the negative pole of the source, and

a resistor mounted parallel to the terminals of said condenser.

3. A system according to claim 1 wherein said comparison unit includes:

a sequencing clock, one input terminal of which is connected to the output terminal of said rectifier/filter assembly,

two switches each placed under the control of said clock and connected to one another at one of their transient terminals,

said first switch, through its other transient terminal, being connected to one of the terminals of a voltage dividing bridge, itself linked to the output terminal of said rectifier/filter assembly, the other terminal of the dividing bridge being connected to the negative pole of the source, and

said second switch being connected, also through its other transient terminal, to a lead-in of the comparator, the clock and the two switches,

a condenser connected on one side to the negative pole of said source and on the other at the site of a linkage between the two switches.

4. A system according to claim 3, further including two comparators,

the first being connected by its two lead-ins respectively to the output terminal of said rectifier/filter assembly and to said other transient terminal of the second switch, the lead-out of this first comparator being directly linked to said signaling device,

the second comparator being placed between the output terminal of said rectifier/filter assembly and the input terminal of said clock, the comparison unit to which is connected one of the lead-ins of this second comparator being of the type delivering a determined, fixed voltage.

5. A system according to claim 4, further comprising two voltage followers each placed between the output terminal of said rectifier/filter assembly and the corresponding lead-in of the comparator which is subjected to the voltage difference between that delivered by said rectifier/filter assembly and that delivered by said comparison unit, both followers being fed by said DC source.

6. A system according to claim 1, wherein said capsule is formed by a conducting metal wall forming the bottom of the capsule, on which is molded the remainder of the capsule in non-conducting plastic, including the tight, perforatable partition opposite the bottom wall.

7. A system according to claim 6, wherein the capsule'"'"'s metal bottom is formed by a part shaped by stamping, having the shape of a basin closable on its upper part by the perforatable partition forming the cover.

8. A system according to claim 6, including a metal adapter attached to said metal bottom connecting the inside of the capsule to the implanted dispensing tube.