Multilayer chemical analytical element

• US 4,781,890 A
• Filed: 02/05/1987
• Issued: 11/01/1988
• Est. Priority Date: 11/18/1983
• Status: Expired due to Term

• Current Assignee: Fuji Photo Film Co Limited (Fujifilm Holdings Corporation)
• Original Assignee: Fuji Photo Film Co Limited (Fujifilm Holdings Corporation)
• Inventors: Yazawa, Kenichiro, Arai, Fuminori, Katsuyama, Harumi
• Primary Examiner(s): Richman, Barry S.
• Assistant Examiner(s): WARDEN, JILL ALICE
• Application Number:
  US07/011,386
• Time in Patent Office: 635 Days
• Field of Search: 422/56, 422/57, 422/58, 436/95, 436/170, 436/175, 435/14, 435/29, 435/805
• US Class Current: 422/428
• CPC Class Codes: C12Q 1/26 involving oxidoreductase
• CPC Class Codes: G01N 31/22 using chemical indicators G01N31/02 takes precedence
• CPC Class Codes: G01N 33/525 Multi-layer analytical elements
• CPC Class Codes: Y10S 435/805 Test papers
• CPC Class Codes: Y10T 436/144444 Glucose
• CPC Class Codes: Y10T 436/25125 Digestion or removing interfering materials

Abstract

A multilayer chemical analytical element is employable in quantitative analysis of analyte in a biological fluid such as blood. The element consists of a porous spreading layer, a light-blocking layer and a reagent layer on a water-impermeable light-transmissive support in order. The light-blocking layer contains a titanium dioxide fine powder with no provision of aluminum oxide compound or silicon oxide.

Claims

1. In a multilayer chemical analytical element which includes a porous spreading layer, a light-blocking layer and a reagent layer on a water-impermeable light-transmissive support in order, wherein the improvement comprises having said light-blocking layer contain a titanium dioxide fine powder having neither an aluminum oxide compound nor silicon oxide, the element containing a compound having a cation which is capable of forming a sparingly water soluble salt with flourine anion.

2. The analytical element according to claim 1, wherein said reagent layer contains peroxidase and a hydrogen peroxide indicator which is capable of showing a detectable change in the presence of said peroxidase and hydrogen peroxide.

3. The analytical element according to claim 1, wherein said cation is a cation selected from the group consisting of divalent calcium and divalent magnesium.

4. The analytical element according to claim 1, wherein said titanium dioxide fine powder is in a crystalline form selected from the group consisting of anatase, rutile and brookite.

5. The analytical element according to claim 1, wherein said light-blocking layer includes a surfactant.

6. The analytical element according to claim 5, wherein said surfactant is a non-ionic surfactant.