Method and apparatus for taking samples from or administering medication to a patient

• US 4,784,157 A
• Filed: 01/28/1987
• Issued: 11/15/1988
• Est. Priority Date: 02/04/1986
• Status: Expired due to Fees

• Current Assignee: David W. Hawes, Heinz S. Wolff, Justin A.T. Halls, Richard D. Vahrman
• Original Assignee: David W. Hawes, Heinz S. Wolff, Justin A.T. Halls, Richard D. Vahrman
• Inventors: Halls, Justin A. T., Vahrman, Richard D., Hawes, David W., Wolff, Heinz S.
• Primary Examiner(s): HINDENBURG, MAX F
• Application Number:
  US07/007,678
• Time in Patent Office: 657 Days
• Field of Search: 128/762-766, 604/28, 604/35, 604/36, 604/38, 604/51, 604/52, 604/53, 604/151, 604/66, 604/191, 604/246
• US Class Current: 600/575
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/150229 Pumps for assisting the blood sampling
• CPC Class Codes: A61B 5/150992 Blood sampling from a fluid line external to a patient, such as a catheter line, combined with an infusion line; blood sampling from indwelling needle sets, e.g. sealable ports, luer couplings, valves tubing connectors and couplings A61M39/00
• CPC Class Codes: A61M 5/1408 in parallel, e.g. manifolds, sequencing valves access sites A61M39/02; tube connectors A61M39/10
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407

Abstract

A controlled apparatus for withdrawing fluids from a patient or for administering medication to a patient, or both, which controlled apparatus may be remotely and/or automatically controlled. The apparatus includes a manifold and cannula for connecting the manifold to a patient, one or more syringes connected to the manifold, a pump for pumping liquid into and out of the manifold and a controller for controlling the operation of the syringes and the pump. A method of using the apparatus is also provided.

The controlled apparatus is especially useful for the programmed withdrawal of blood from a blood vessel of a patient.

Claims

1. A method of taking a plurality of blood samples from a blood vessel of a patient, using a like plurality of syringes therefor, said method comprising:

(a) connecting a manifold to said blood vessel;

(b) pumping at a slow rate anticoagulant through said manifold into said blood vessel;

(c) interrupting pumping step (b) and then drawing from said patient into said manifold at a rapid rate blood for said sampling;

(d) actuating a separate one of said plurality of syringes to remove from said manifold a sampling of blood;

(e) discontinuing the actuation of each such syringe prior to the complete filling thereof with blood;

(f) then flushing said manifold of blood by pumping therein at a rapid rate anticoagulant;

(g) then reactuating the partially filled syringe to draw from said manifold anticoagulant; and

(h) then returning to step (b) to operate another syringe to take another blood sample.

2. The method of claim 1 wherein the anticoagulant being pumped through said manifold into said blood vessel is pumped at a perfusion rate about two milliliters per hour.

3. A method according to claim 1 wherein the flushing of said manifold of blood by pumping therein at a rapid rate anticoagulant is carried out at a perfusion rate of about 20 milliliters per hour.

4. The method according to claim 3 wherein the anticoagulant is pumped through said manifold into said blood vessel during step (b) at a rate of about two milliliters per hour.

5. Apparatus for taking a blood sample comprising a manifold, means for connecting said manifold to a blood vessel of a patient, a syringe connected to said manifold for drawing a blood sample therefrom and fluid flow means operatively connected to the manifold for drawing blood into the manifold before sampling and for flushing said manifold afterwards with anticoagulant liquid, wherein said fluid flow means includes a reservoir for anticoagulant liquid and a reversible pump therefor, said apparatus further comprising control means for controlling the reversible pump and syringe so that before sampling blood with the syringe the reversible pump slowly pumps anticoagulant liquid into the patient, during sampling with the syringe the reversible pump rapidly pumps blood into the manifold, and after sampling blood with the syringe the reversible pump flushes the manifold rapidly with anticoagulant liquid.

6. The apparatus of claim 5 wherein the reversible pump is a peristaltic pump.

7. The apparatus of claim 5 wherein the reservoir has a self-sealing cap to permit refilling of the reservoir with anticoagulant liquid.

8. The apparatus of claim 7 wherein the reversible pump is a peristaltic pump.

9. Apparatus for taking a blood sample comprising a manifold which is adapted to receive a blood sampling syringe, means for connecting said manifold to a blood vessel of a patient, and fluid flow means operatively connected to the manifold for drawing blood into the manifold before sampling and for flushing said manifold afterwards with anticoagulant liquid, wherein said fluid flow means includes a reservoir for anticoagulant liquid and a reversible pump therefor, said apparatus further comprising control means for controlling the reversible pump and the syringe when a syringe is connected to the manifold so that before sampling blood with the syringe the reversible pump slowly pumps anticoagulant liquid into the patient, during sampling with the syringe the reversible pump rapidly pumps blood into the manifold, and after sampling blood with the syringe the reversible pump flushes the manifold rapidly with anticoagulant liquid.

10. The apparatus of claim 9 wherein the reversible pump is a peristaltic pump.

11. The apparatus of claim 9 wherein the reservoir has a self-sealing cap to permit refilling of the reservoir with anticoagulant liquid.

12. The apparatus of claim 11 wherein the reversible pump is a peristaltic pump.

13. A method of taking a blood sample comprising:

(a) connecting a manifold to a blood vessel of a patient;

(b) drawing blood from the patient into the manifold for sampling;

(c) drawing a blood sample from said manifold with a syringe; and

(d) flushing said manifold with anticoagulant after taking said blood sample;

wherein, before blood sampling steps (b) and (c), anticoagulant liquid is pumped slowly into the patient;

during step (b), the blood is drawn rapidly from the patient'"'"'s blood vessel into the manifold; and

wherein flushing is carried out immediately after blood sampling steps (b) and (c) by pumping at a rapid rate anticoagulant into the manifold to displace the blood therein, and after said flushing anticoagulant liquid is again pumped slowly into the patient.

14. A method as claimed in claim 13, wherein the syringe is activated twice for drawing a sample, once to collect the blood sample without completely filling the syringe with blood and a second time to aspirate anticoagulant liquid into the syringe.

15. Apparatus for taking blood samples from an ambulatory patient, said apparatus including housing means adapted to be carried on the patient, and further including:

a manifold for connection with the patient, a plurality of syringes for successively drawing blood from said manifold, and fluid flow means for drawing blood into the manifold before sampling and for flushing it afterwards with anticoagulant liquid, wherein the fluid flow means includes a reservoir for anticoagulant liquid, a reversible pump therefor and control means for controlling the pump and syringes, so that the pump

(a) between samples pumps anticoagulant liquid into the patients blood vessel,

(b) pumps blood into the manifold for each successive sampling of blood, and

(c) after each said sampling flushes the manifold with said anticoagulant liquid,

wherein the control means further activates in sequence said syringes to collect samples from the manifold when blood is present therein, and wherein the manifold, syringes and fluid flow means are housed in said housing means.

16. Apparatus as claimed in claim 15, wherein after sampling by each such syringe, said last activated syringe is again activated to draw in anticoagulant liquid from the manifold.

17. Apparatus as claimed in claim 15 further comprising means for injecting fluid into said patient for treatment of the patient.

18. A method of taking a plurality of blood samples from an ambulatory patient using the apparatus of claim 15, comprising:

connecting the manifold to a blood vessel of said patient;

activating the series of syringes in succession at predetermined intervals of time to draw samples from the manifold; and

drawing blood from the patient into the manifold before sampling and flushing said manifold after blood sampling with anticoagulant liquid, wherein between samples anticoagulant liquid is pumped slowly into the vein;

immediately before each sampling, blood is drawn rapidly from the vein into the manifold; and

immediately after each sampling anticoagulant liquid is pumped into the manifold to pump the liquid in the manifold into the patient to displace the blood in the manifold with anticoagulant.

19. A method as claimed in claim 18, wherein after each sampling, the syringe last employed for blood sampling is again activated to draw in anticoagulant liquid from the manifold into the syringe.

20. A method as claimed in claim 18, further including the step of at least after one sampling injecting fluid for treatment of the patient into the liquid in the manifold prior to said liquid in the manifold being pumped into the patient.