Vessel and prosthesis impregnated with diisocyanate crosslinked gelatin

• US 4,784,659 A
• Filed: 03/03/1987
• Issued: 11/15/1988
• Est. Priority Date: 03/12/1986
• Status: Expired due to Term

• Current Assignee: B Braun-Ssc AG
• Original Assignee: Intermedicat GmbH
• Inventors: Werner, Heinz-Helmut, Fleckenstein, Peter
• Primary Examiner(s): Apley, Richard J.
• Assistant Examiner(s): PREBILIC, PAUL B
• Application Number:
  US07/021,129
• Time in Patent Office: 623 Days
• Field of Search: 8/94.11, 128/DIG. 8, 427/2, 428/308.4, 428/423.7, 428/253, 428/254, 623/1, 623/2, 623/11, 623/12, 623/13, 623/66
• US Class Current: 623/1.45
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/507 for artificial blood vessels apparatus for applying cells on a blood vessel prosthesis A61F2/062
• CPC Class Codes: C08L 89/00 Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00
• CPC Class Codes: C08L 89/06 derived from leather or skin , e.g. gelatin
• CPC Class Codes: Y10S 128/08 Collagen
• CPC Class Codes: Y10S 623/901 Method of manufacturing prosthetic device
• CPC Class Codes: Y10S 623/921 Blood vessel
• CPC Class Codes: Y10T 428/31565 Next to polyester [polyethylene terephthalate, etc.]

Abstract

The invention relates to vessel prostheses formed from a porous vascular prosthesis impregnated with diisocyanate crosslinked gelatin for sealing the pores.

Claims

1. An implantable vessel prosthesis comprising a porous tubular structure sealed by impregnation with a material containing gelatin which is crosslinked with a diisocyanate so that pores of the structure are filled with an insoluble crosslinked gelatin/diisocyanate decomposable at a rate of tissue growth into the pores on implantation of the prosthesis.

2. The vessel prosthesis defined in claim 1 wherein said tubular structure is a textile structure.

3. The vessel prosthesis defined in claim 1 wherein portions of the tubular structure bounding the pores are coated with a thin film of crosslinked gelatin and the pores are closed by gelatin membranes.

4. The vessel prosthesis defined in claim 1 wherein the weight ratio of the tubular structure to the impregnating material is 1:

0.2 to 1;

3.

5. The vessel prosthesis defined in claim 1 wherein the impregnating material contains a hydrophilic plasticizer.

6. The vessel prosthesis defined in claim 1 wherein the impregnating material contains 10 to 30 % by weight of water.

7. The vessel prosthesis defined in claim 1 wherein the diisocyanate is an aliphatic diisocyanate.

8. The vessel prosthesis defined in claim 1, wherein the impregnating material includes at least one therapeutically active material.

9. The vessel prosthesis defined in claim 8 wherein the impregnating material contains constituents with exchanger characteristics.

10. The vessel prosthesis according to claim 8 wherein the therapeutical active material is incorporated in a manner producing a delayed-release effect.