Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a)

• US 4,787,888 A
• Filed: 06/01/1987
• Issued: 11/29/1988
• Est. Priority Date: 06/01/1987
• Status: Expired due to Fees

• Current Assignee: University of Connecticut Storrs CT
• Original Assignee: University of Connecticut (State of Connecticut)
• Inventors: Fox, Martin D.
• Primary Examiner(s): NOT, DEFINED
• Assistant Examiner(s): Lewis, Ralph
• Application Number:
  US07/056,471
• Time in Patent Office: 547 Days
• Field of Search: 604/20, 604/22, 604/890, 604/896, 604/897, 604/304, 604/305, 604/307, 128/24 A, 128/421, 128/798, 128/804
• US Class Current: 604/20
• CPC Class Codes: A61K 41/0047 Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
• CPC Class Codes: A61M 2037/0007 having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428

Abstract

A bandage assembly for percutaneous administration of a medicament generates sonic vibrations to produce sonophoresis. The assembly has a bandage member with a cavity containing a medicament and having a piezoelectric polymer element extending thereacross. An sonic generator is coupled to the piezoelectric polymer element to supply it with energy to produce sonic vibrations perpendicular to the skin to drive the medicament into the pores. A second piezoelectric polymer element may surround the cavity to generate vibrations parallel to the skin to stretch the pores.

Claims

1. A bandage assembly for percutaneous administration of a medicament comprising:

a. a bandage member having inner and outer surfaces and a cavity functionally opening on said inner surface thereof, said bandage member including a body element extending across said cavity adjacent said outer surface of said bandage member and fabricated from a piezoelectric polymer to generate vibrations perpendicularly to said inner surface, said bandage member having said inner surface adapted to be placed against the skin;

b. a medicament composition in said cavity;

c. electrical leads on said body element to supply energy thereto; and

d. sonic generator means connected to said leads to generate sonic vibrations in said body element to induce percutaneous transfer of the medicament composition, said vibrations being within a frequency range of about 20 Hz to 2 kHz.

2. The bandage assembly in accordance with claim 1 wherein said bandage member includes means for securing it to the skin of a user.

3. The bandage assembly in accordance with claim 2 wherein said bandage member has an adhesive coating on said one surface thereof about said cavity to provide said securing means.

4. The bandage assembly in accordance with claim 1 wherein said body element includes two layers of piezoelectric polymer to produce a bimorph.

5. The bandage assembly in accordance with claim 1 wherein said piezoelectric polymer is polyvinylidene fluoride.

6. The bandage assembly in accordance with claim 1 wherein an additional portion of said bandage member surrounding said cavity is fabricated from a piezoelectric polymer connected to said generator means.

7. The bandage assembly in accordance with claim 6 wherein said additional portion generates vibrations parallel to said inner surface of said bandage member.

8. The bandage assembly in accordance with claim 6 wherein said additional portion surrounding said cavity is adopted to effect stretching of the skin.

9. The bandage assembly in accordance with claim 8 wherein said bandage member has adhesive thereon about said cavity to secure it to the skin.

10. The bandage assembly in accordance with claim 1 wherein said medicament composition includes a medicament dispersed in an ultrasonic medium.

11. The bandage assembly in accordance with claim 1 wherein said sonic generator includes a battery power source, a microprocessor and an oscillator.

12. The bandage assembly in accordance with claim 11 including a switch for controlling the generation of said sonic vibrations.

13. The bandage assembly in accordance with claim 11 wherein said microprocessor controls the rate and frequency of the sonic vibrations generated thereby.

14. The bandage assembly in accordance with claim 1 wherein said body element is a bimorph polymer and said bandage member includes an annular element of piezoelectric polymer extending about said cavity.

15. The bandage assembly in accordance with claim 1 wherein said bandage member includes a piezoceramic member spaced above said body element and coupled to a sonic generator means to generate high frequency sonic vibrations.

16. The bandage assembly in accordance with claim 15 wherein said sonic generator means includes means for supplying high frequency energy to said piezoceramic member.

17. In a method for the percutaneous administration of medicaments, the steps comprising:

a. forming a bandage member having inner and outer surfaces and a cavity functionally opening on said inner surface thereof, such bandage member including a body element extending across said cavity adjacent said outer surface of said bandage member and fabricated from a piezoelectric polymer to generate vibrations perpendicular to said inner surface, said bandage member having said inner surface adapted to be placed against the skin and having electrical leads on said body element;

b. placing a medicament composition in said cavity;

c. securing said inner surface of said bandage member against the skin of the user;

d. connecting sonic generator means to said leads; and

e. operating said generator means to produce sonic vibrations of said body element to induce percutaneous transfer of said medicament composition, said vibrations being within a frequency range of 20 Hz to 2 KHz.

18. The method in accordance with claim 17 wherein said bandage member is adhesively engaged to the skin about said cavity.

19. The method in accordance with claim 17 wherein said piezoelectric polymer is polyvinylidene fluoride.

20. The method in accordance with claim 17 wherein said bandage member is fabricated with an additional portion of piezoelectric polymer disposed about said cavity and connected to said generator means.

21. The method in accordance with claim 20 wherein said additional portion generates vibrations parallel to said skin.

22. The method in accordance with claim 20 wherein said additional portion surrounds said cavity to effect stretching of the skin.

23. The method in accordance with claim 17 including the additional step of programming a microprocessor in said sonic generator to control the rate and frequency of the sonic vibrations generated thereby.

24. The method in accordance with claim 17 wherein said body element is formed as a bimorph and said bandage member is fabricated with an annular element of piezoelectric polymer extending about said cavity.