Control system and method for improved laser angioplasty

• US 4,788,975 A
• Filed: 11/05/1987
• Issued: 12/06/1988
• Est. Priority Date: 11/05/1987
• Status: Expired due to Term

• Current Assignee: Trimedyne Incorporated (InnovaQuartz, LLC)
• Original Assignee: Medilase Incorporated
• Inventors: Jensen, Steven L., Shturman, Leonid
• Primary Examiner(s): HINDENBURG, MAX F
• Application Number:
  US07/117,666
• Time in Patent Office: 397 Days
• Field of Search: 128/6, 128/303.1, 128/395-398, 128/419 P, 128/419 R, 219/121.61, 219/121.62
• US Class Current: 606/7
• CPC Class Codes: A61B 18/20 using laser
• CPC Class Codes: A61B 2018/00636 Sensing and controlling the application of energy
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval

Abstract

A control system and method for laser angioplasty or laser ablation or welding of tissue in general, in which firing of a laser catheter is correlated with movement of a vessel or other body chamber carrying the laser catheter, whereby the laser is fired only during those times its fiberoptic-delivered beam is aimed at plaque or other target in the vessel or chamber.

Claims

1. In combination with a laser angioplasty system in which a laser catheter is positioned within a moving vessel and oriented to impinge radiation upon a selected target site within the vessel, the improvement comprising:

means for defining a cycle representative of repetitive vessel movement;

means for defining the position of the laser catheter relative to the selected target site during various times of the cycle, and

means for activating the laser catheter at a selected time or times to impinge laser radiation on the target site during an upcoming cycle or cycles.

2. The combination of Claim 1 in which the means for defining a cycle representative of vessel movement defines an aspect of the cardiac cycle.

3. The combination of claim 1 in which the vessel is a coronary artery and the means for defining a cycle representative of vessel movement defines an characteristic relative to the coronary artery.

4. The combination of claim 1 wherein the means for defining the cycle includes electrocardiographic data.

5. The combination of claim 4 wherein the cycle is defined by the QRS complex.

6. The combination of claim 1 wherein the means for defining the position of the laser catheter includes at least one imaging system.

7. In combination with a laser angioplasty system for the delivery of laser energy to atherosclerotic plaque in a vessel and for ablation of the plaque therein, the combination comprising:

a laser catheter including an actuating mechanism therefore;

first means responsive to an aspect representative of repetitive vessel movements for defining a time period cycle representative thereof and for dividing the time period cycle into a variable number of fixed times or time intervals;

second means responsive to the relative positions of the laser catheter and the plaque in the vessel for identifying those times or time intervals during a cycle (or a cardiac cycle) when the laser catheter is aimed at the plaque and those times or time intervals when it is not, and

computer means responsive to said first means and said second means for controlling the actuation of the laser catheter during at least one time or time interval of an upcoming cardiac cycle in which the laser catheter is oriented to the plaque.

8. The combination of Claim 7 in which the aspect representative of repetitive vessel movement relates to the cardiac cycle.

9. The combination of claim 7 wherein the first means includes electrocardiographic data and further includes associated means for defining a time period represented by the electrocardiogram QRS complex generated thereby and for defining a plurality of times therebetween.

10. The combination of claim 7 wherein the second means includes image acquisition and processing means for visually displaying on a CRT images of the vessel toward which the catheter is oriented and orientation of the catheter or its aiming mechanism relative to a target area.

11. The combination of claim 10 wherein the second means includes angiography imaging means.

12. The combination of claim 10 wherein the second means includes angioscopic imaging means.

13. The combination of claim 7 wherein the second means includes signal generating means and sensing means for sensing when the catheter is oriented toward the plaque in the vessel.

14. The combination of claim 13 wherein the second means includes a laser induced fluorescent signal.

15. The combination of claim 13 wherein the second means includes ultrasound signal means.

16. The combination of claim 7 wherein the first and second means generate electrical output signals representative of time and positional data, respectively.

17. The combination of claim 16 wherein the computer means is electronically connected to the first and second means and includes electronic data storage and display means for storing and displaying the time and positional data at operator command.

18. The combination of claim 17 wherein the computer means further includes manual data entry means for selecting certain times or time intervals during which the catheter is oriented toward plaque in the vessel.

19. The combination of claim 18 further including means for automatically triggering the firing of the laser catheter during the selected time intervals during an upcoming cycle or cycles.

20. The combination of claim 18 including means for deactivating the laser catheter.

21. In combination with a medical treatment device in which a treatment means is positioned within a moving body and oriented toward a selected site therewithin for effecting treatment thereof, the improvement comprising:

means for defining a repetitive time cycle representative of body movement;

means for defining the position of the treatment means relative to the selected site during various times of the time cycle, and

means for activating the treatment means at a selected time or times to effect treatment of the selected site.

22. In combination with a medical treatment system for effecting treatment to a selected site in a body or body part, the combination comprising:

medical treatment means inserting into the body including an actuating mechanism therefore;

first means responsive to repetition body movements for defining a time period representative thereof and for dividing the time period into a variable number of fixed times;

second means responsive to the relative positions of the medical treatment means and the site in the body for identifying those times or time intervals during a time period when the treatment means is oriented toward the site and those times or time intervals when it is not, and

computer means responsive to said first means and said second means for controlling the actuation of the medical treatment means during at least one time or time interval of a cycle in which it is oriented toward selected site during upcoming cycle.

23. A method of timing the actuation of a laser angioplasty catheter carried in a moving vessel to assure impingement of laser radiation upon atherosclerotic plaque rather than on the vessel wall, the method comprising:

inserting the catheter into a vessel and positioning it toward a target area therein;

establishing a repeating time cycle based on vessel movement, including discrete times within the cycle;

selecting those discrete times in the cycle during which the catheter aiming mechanism is aimed at the plaque, and

arranging for the actuation of the laser during at least one of those determined discrete times in an upcoming cycle.

24. The method of claim 23 in which the step of selecting those times when aiming is at the plaque includes the use of an image acquisition, storage and display systems.

25. The method of claim 23 in which the step of selecting those times when aiming is at the plaque includes the use of sensing means for providing data that indicates the orientation of the catheter relative to the plaque.

26. The method of claim 23 in which the step of arranging for actuation of the catheter includes the use of computer means for correlating the selecting step with the actuation of the laser.

27. The method of claim 23 wherein the selecting step includes data from a plurality of modalities, some associated with the catheter per se and some independent thereof.

28. A method of timing the actuation of a medical treatment system in which a medical treatment means is inserted into the body and to assure effecting treatment by the means to a selected site in the body, the method comprising:

inserting the medical treatment means into the body and positioning it toward a selected site therein;

establishing a repeating time cycle based on certain body movement, including discrete times within the cycle;

selecting those discrete times in the cycle during which the medical treatment means is oriented toward the site and

arranging for the actuation of the medical treatment means during at least one of those determined discrete times or time intervals during an upcoming cycle.