Pacemaker having PVC response and PMT terminating features

• US 4,788,980 A
• Filed: 07/18/1986
• Issued: 12/06/1988
• Est. Priority Date: 07/18/1986
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated), Simens-Pacestter Incorporated
• Original Assignee: Siemens Pacesetter, Inc. (Abbott Laboratories Incorporated)
• Inventors: Buchanan, Stuart W., Mann, Brian M.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Keegan, Timothy
• Application Number:
  US06/887,297
• Time in Patent Office: 872 Days
• Field of Search: 128/419 PG
• US Class Current: 607/14
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions

Abstract

An atrial tracking dual-chamber pacemaker and method of use for reducing the risk of initiating a pacer mediated tachycardia (PMT), and breaking such a PMT if once started. The pacemaker includes means for sensing a premature ventricular contraction (PVC). The pacemaker operates in a conventional manner unless a PVC is sensed. If a PVC is sensed, in accordance with one embodiment, an extended atrial refractory period is triggered in an attempt to block any retrograde atrial events resulting from the PVC. This is followed by an atrial alert time window. After a prescribed A-V delay subsequent to the timing out or other termination of the atrial alert time window, a ventricular stimulation pulse is generated, unless prior ventricular activity is sensed that inhibits such ventricular stimulation pulse. In accordance with another embodiment, the sensing of a PVC triggers, after a suitable refractory period, a retrograde sense period during which any sensed atrial electrical activity is presumed to be a retrograde event. Appropriate steps are taken in order to deal with the retrograde event to prevent its occurrence from triggering a PMT. If a PMT has started, a prescribed number of cycles of the PMT are counted, after which the same action used in response to a sensed PVC is triggered, which action disrupts the rhythm of the PMT so as to break it. If the PMT is not broken with the first attempt, the PVC response is recurringly generated after a prescribed number of subsequent PMT cycles.

Claims

1. A method of operating a dual-chamber cardiac pacemaker, said dual-chamber cardiac pacemaker including means for sensing a premature ventricular contraction (PVC), comprising the steps of:

(a) generating an extended atrial refractory period upon the sensing of a PVC, said extended atrial refractory period comprising a first prescribed time period during which electrical activity in the atrium of a heart being paced by said pacemaker is not sensed by said pacemaker;

(b) generating an atrial alert time interval that is initiated at the conclusion of the extended atrial refractory period, said atrial alert time interval comprising a second prescribed time period during which electrical activity in the atrium is sensed, but during which no pacemaker-generated stimulation pulses are delivered to the atrium;

(c) delivering a pacemaker-generated stimulation pulse to the atrium at the conclusion of the atrial alert time interval only when no electrical activity is sensed in the atrium during the atrial alert time interval; and

(d) generating an A-V time interval that is initiated at the conclusion of the atrial alert time interval, said A-V time interval comprising a third time period at the conclusion of which a ventricular stimulation pulse may be selectively delivered to the ventricle of the heart by said pacemaker.

2. The method of claim 1 wherein the ventricular stimuation pulse is delivered to the ventricle at the conclusion of the A-V time interval in step (d) only when there is no sensed electrical activity in the ventricle during the immediately preceeding A-V time interval.

3. The method of claim 1 wherein the A-V time interval in step (d) is different than a normal A-V time delay period used within said pacemaker.

4. A method of operating a dual-chamber pacemaker, said dual-chamber cardiac pacemaker including means for sensing a premature ventricular contraction (PVC), comprising the steps of:

(a) generating a first time period that begins upon the sensing of a PVC;

(b) generating a second time period that is initiated upon the occurrence of a first prescribed event occurring within said first time period;

(c) delivering an atrial stimulation pulse to the atrium of a heart being paced by said pacemaker at the conclusion of the second time period, unless a second prescribed event occurs during said second time period, in which case no atrial stimulation pulse is generated;

(d) generating a third time period that is initiated at the conclusion of the second time period; and

(e) delivering a ventricular stimulating pulse to the ventricle of the heart at the conclusion of the third time period providing a third prescribed event has previously occurred.

5. The method of claim 4 wherein the third prescribed event of step (e) comprises the absence of sensed electrical activity in the ventricle of the heart during said third time period.

6. The method of claim 4 wherein the third prescribed event of step (e) comprises the absence of sensed electrical activity in the ventricle of the heart for a prior time period that includes said third time period.

7. The method of claim 4 wherein the third time period is different than a normal A-V delay period used within said pacemaker.

8. The method of claim 4 wherein the first prescribed event of step (b) comprises the timing to of said first time period.

9. The method of claim 4 wherein the first prescribed event of step (b) comprises an atrial event.

10. The method of claim 9 wherein said atrial event comprises the sensing of electrical activity in the atrium of the heart.

11. The method of claim 4 wherein said second time period comprises an atrial alert time period that has a prescribed duration that falls within the range of from 250 to 450 msec.

12. The method of claim 11 wherein said second time period has a fixed duration selected to fall in the range of from 300 to 350 msec.

13. The method of claim 4 wherein said second time period is divided into first and second portions, the first portion of which is refractory with respect to atrial electrical activity.

14. A method of operating a dual-chamber pacemaker, said pacemaker including means for sensing atrial and ventricular activity, as well as means for sensing a premature ventricular contraction (PVC), comprising the steps of:

(a) generating, in response to sensing, ventricular activity, an atrial escape interval and a maximum tracking interval, at least a latter portion of said atrial escape interval comprising a time period during which atrial activity is sensed, an A-V interval being generated at the earliest occurrence of either;

(1) the sensing of atrial activity within the latter portion of said atrial escape interval or (2) the conclusion of said actual escape interval, said maximum tracking interval plus said A-V interval comprising a time period that defines a maximum pacing rate of said pacemaker;

(b) suspending said atrial escape interval and said maximum tracking interval in response to the sensing of atrial activity within the latter portion of said atrial escape interval that occurs subsequent to the sensing of a PVC;

(c) generating, in response to the sensing of atrial activity, said A-V interval; and

(d) generating a ventricular stimulating pulse at the conclusion of said A-V interval.

15. The method of claim 14 wherein the suspension of the atrial escape interval and the maximum tracking interval in response to the sensing of post PVC atrial activity in accordance with step (b) is continued only for a prescribed number of consecutive cardiac cycles.

16. A method of breaking a pacer mediated tachycardia (PMT) in a dual-chamber cardiac pacemaker, said dual-chamber cardiac pacemaker including sensing means for selectively sensing electrical activity in a ventricle and an atrium of a heart, and pacing means for selectively delivering stimulation pulses to at least the ventricle in accordance with a prescribed timing sequence, said method of breaking a PMT comprising the steps of:

(a) counting a prescribed number of PMT cycles; and

(b) extending the time at which said pacing means delivers one of said stimulation pulses to the ventricle in the next PMT cycle, thereby changing the V--V interval of this next PMT cycle.

17. The PMT breaking method of claim 16 further including the step of:

(c) repeating steps (a) and (b) until the PMT is broken.

18. The PMT breaking method of claim 17 wherein the prescribed number of PMT cycles counted in step (a) includes a first prescribed number of PMT cycles to be counted prior to the extension of the initial V--V interval applied in step (b), and a second prescribed number of PMT cycles to be counted subsequent to the initial V--V interval extension.

19. The PMT breaking method of claim 18 wherein the first prescribed number of PMT cycles to be counted is at least 10.

20. The PMT breaking method of claim 19 wherein the second prescribed number of PMT cycles to be counted is no more than 130.

21. The PMT breaking method of claim 18 wherein the first prescribed number of PMT cycles to be counted is at least 127.

22. The PMT breaking method of claim 16 wherein step (b) comprises

(1) applying an extended atrial refractory period to the sensing means of said pacemaker immediately subsequent to the generation of the ventricular stimulation pulse of the selected PMT cycle, said extended atrial refractory period comprising a time interval during which the sensing means is unable to sense electrical activity in the atrium,

(2) applying an atrial alert period to the sensing means and pacing means of the pacemaker immediately subsequent to the timing out of said extended atrial refractory period, said atrial alert period comprising a time interval during which the sensing means is able to sense electrical activity in the atrium, but during which the pacing means is inhibited from delivering any stimulation pulses to the atrium, and

(3) applying an A-V interval period to the sensing means and pacing means of the pacemaker immediately subsequent to the timing out of said atrial alert period, said A-V interval comprising a time interval after the duration of which a ventricular stimulation pulse will be delivered to the ventricle unless electrical activity is sensed in the ventricle during said A-V interval.

23. The PMT breaking method of claim 22 wherein said A-V interval period comprises a selected time period that is different than a normal A-V delay time period used within said pacemaker.

24. The PMT breaking method of claim 16 wherein step (b) comprises

(1) applying a first time interval to the sensing means of said pacemaker immediately subsequent to the generation of the ventricular stimulation pulse of the selected PMT cycle, said first time interval comprising a refractory period during which the sensing means is blocked from sensing electrical activity in the atrium,

(2) applying a second time interval to the sensing means of the pacemaker immediately subsequent to the timing out of the first time interval, said second time interval comprising a time during which the sensing means is able to sense electrical activity in the atrium,

(3) if atrial electrical activity if sensed during said second time interval, applying a third time interval to the sensing means of the pacemaker immediately subsequent to the sensing of said atrial electrical activity during said second time interval,

(4) applying a fourth time interval to the sensing and pacing means of the pacemaker immediately subsequent to the ending of said third time interval of step (3), or if no atrial electrical activity is sensed during said second time interval, applying said fourth time interval immediately subsequent to an atrial escape interval, said atrial escape interval being initiated concurrent with said first time period and

(5) delivering a ventricular stimulation pulse to the ventricle at the conclusion of said forth time interval in the absence of sensed ventricular activity occurring during said fourth time interval.

25. In a pacemaker having means for detecting the occurrence of a premature ventricular contraction (PVC), and means for sensing first and second cardiac events associated with the operation of said pacemaker, a system for responding to a PVC comprising:

means for generating a first time period that begins upon the sensing of a PVC by said PVC detection means;

means for generating a second time period that is initiated upon the occurrence of said first prescribed cardiac event occurring during said first period;

means for generating a third time period that is initiated upon the occurrence of said second prescribed cardiac event; and

delivery means for selectively delivering a stimulation pulse to a ventricle of a heart being paced by said pacemaker at the end of said third time period.

26. The pacemaker of claim 25 wherein the first prescribed event that triggers the generation of said second time period is the timing out of said first time period.

27. The pacemaker of claim 26 wherein said pacemaker further includes means for sensing atrial activity in an atrium of the heart, and wherein said delivery means further delivers a stimulation pulse to the atrium at the end of said second time period unless atrial activity is sensed in said atrium during said second time period.

28. The pacemaker of claim 27 wherein the second prescribed event that triggers the generation of said third time period is the sensing of atrial activity during said second time period.

29. The pacemaker of claim 27 wherein the second prescribed event that triggers the generation of said third time period is the timing to of said second time period.

30. The pacemaker of claim 25 wherein said pacemaker further includes means for sensing atrial activity in an atrium of the heart, during a latter portion of said first time period, and wherein the first prescribed event that triggers the generation of said second time period comprises the sensing of atrial activity in the atrium by said atrial sensing means.

31. The pacemaker of claim 30 wherein said second time period is divided into an initial refractory portion and a subsequent alert portion, said atrial sensing means being inoperable during said refractory portion and operable during said alert portion.

32. The pacemaker of claim 25 wherein said third time period comprises a time period that is different than an A-V delay period used by said pacemaker when a PVC is not sensed.

33. A cardiac pacemaker including

atrail and ventricular sensing means for respectively sensing atrial and ventricular depolarizations of a heart;

pulse generating means for generating stimulation pulses that may be selectively delivered to the ventricle in response to a ventricular trigger signal;

timing means for generating said ventricular trigger signal in response to a prescribed timing sequence, said timing means including

inhibiting means responsive to said ventricular sensing means for inhibiting said ventricular trigger signal in response to sensed ventricular depolarizations,

premature ventricular contraction (PVC) means for sensing a premature ventricular contraction, said premature ventricular contraction comprising a ventricular depolarization that occurs subsequent to a prior ventricular depolarization and prior to an atrial depolarization or the timing out of an atrial escape interval, whichever occurs first, and for generating a PVC signal in response to the sensing of a PVC,

means for generating an extended atrial refractory period in response to said PVC signal, said extended atrial refractory period comprising a period of time during which the atrial sensing means of said pacemaker is not operable,

means for generating an atrial alert time window subsequent to the timing to of said extended atrial refractory period, said atrial alert time window comprising a prescribed period of time during which the atrial sensing means is operable, and

means for generating an A-V interval that begins at the conclusion of said atrial alert time window, said A-V interval comprising a prescribed period of time during which the ventricular sensing means is operable, said ventricular trigger signal being generated at the conclusion of said A-V interval unless said ventricular trigger signal is inhibited by said inhibiting means.

34. The pacemaker of claim 33 wherein the prescribed period of time of said atrial alert time window comprises 300 to 350 msec.

35. The pacemaker of claim 33 wherein the prescribed time period of said A-V interval is shortened in response to said PVC signal.

36. The pacemaker of claim 33 further including pacemaker mediated tachycardia (PMT) breaking means within said timing means for breaking a tachycardia caused at least in part by said pacemaker, said PMT breaking means comprising

tachycardia signaling means for signaling the occurrence of a sustained PMT as sensed through said atrial and ventricular sensing means,

counting means responsive to said tachycardia signaling means for counting the number of cycles that occur in said sustained PMT,

means for generating said PVC signal in response to a prescribed count reached by said counting means, which PVC signal triggers the generation of said extended atrial refractory period, which in turn causes said atrial alert time window and A-V interval to be generated, thereby effectuating a change in the rhythm of said sustained PMT, which change in rhythm is intended to break said PMT.

37. The pacemaker of claim 36 wherein the prescribed count reached by said counting means at which the PVC signal is generated comprises at least 10.

38. The pacemaker of claim 36 wherein the prescribed count reached by said counting means at which the PVC signal is generated comprises a count less than 150 and greater than 10.

39. The pacemaker of claim 36 wherein said PVC signal is generated at the nth count of said counting means, and every mth count thereafter until said PMT is broken, where m and n are selected integers.

40. A cardiac pacemaker including

atrial and ventricular sensing means for respectively sensing atrial and ventricular depolarizations of a heart;

pulse generating means for generating stimulation pulses that may be selectively delivered to the ventricle in response to a ventricular trigger signal;

timing means for generating said ventricular trigger signal in response to a prescribed timing sequence, said timing means including

inhibiting means responsive to said ventricular sensing means for inhibiting said ventricular trigger signal in response to sensed ventricular depolarizations,

premature ventricular contraction (PVC) means for sensing a premature ventricular depolarization contraction, said premature ventricular contraction comprising a ventricular depolarization that occurs subsequent to a prior ventricular depolarization and prior to an atrial depolarization or the timing out of an atrial escape interval, whichever occurs first, and for generating a PVC signal in response to the sensing of a PVC,

means for generating and atrial refractory period in response to said PVC signal, said atrial refractory period comprising a prescribed period of time during which the atrial sensing means of said pacemaker is not operable,

means for generating a retrograde sense period subsequent to said atrial refractory period during which the atrial sensing means is operable,

means for generating an atrial escape interval that begins in response to said PVC signal, said atrial escape interval comprising an AEI time period that is at least as long as the duration of the atrial refractory period followed by the retrograde sense period,

means for generating an atrial alert time window of a first prescribed time period that beings in response to the sensing of an atrial depolarization occurring during the retrograde sense period, and

means for generating an A-V interval that begins at the conclusion of said AEI time if no atrial depolarization is sensed during the retrograde sense period, or at the earliest occurrence of either the conclusion of said atrial alert time window or the sensing of an atrial depolarization by said atrial sensing means during said atrial alert time window, said A-V interval comprising a second prescribed time period during which the ventricular sensing means is operable, said ventricular trigger signal being generated at the conclusion of said A-V interval unless said ventricular trigger signal is inhibited by said inhibiting means.

41. The pacemaker of claim 40 wherein the first prescribed period of time of said atrial alert time window comprises 300 to 350 msec.

42. The pacemaker of claim 40 wherein the second prescribed time period of said A-V interval is shortened in response to said PVC signal.

43. The pacemaker of claim 40 further including pacemaker mediated tachycardia (PMT) breaking means within said timing means for breaking a tachycardia caused at least in part by said pacemaker, said PMT breaking means comprising

tachycardia signaling means for signaling the occurrence of a sustained PMT as sensed through said atrial and ventricular sensing means,

counting means responsive to said tachycardia signaling means for counting the number of cycles that occur in said sustained PMT,

means for generating said PVC signal in response to a prescribed count reached by said counting means, which PVC signal triggers the generation of said atrial refractory period, followed by said retrograde sense period and, if atrial activity is sensed, said atrial alert time window, thereby effectuating a change in the rhythm of said sustained PMT, which change in rhythm is intended to break said PMT.

44. The pacemaker of claim 43 wherein the prescribed count reached by said counting means at which the PVC signal is generated comprises at least 10.

45. The pacemaker of claim 43 wherein the prescribed count reached by said counting means at which the PVC signal is generated comprises a count less than 130.

46. The pacemaker of claim 43 wherein said PVC signal is generated at the nth count of said counting means, and every mth count thereafter until said PMT is broken, where m and n are selected integers.

47. An atrial tracking dual-chamber pacemaker comprising

atrial and ventricular sensing means for sensing electrical activity occurring in an atrium and ventricle of a heart, respectively;

pulse generating means coupled to said atrial and ventricular sensing means for generating a ventricular trigger signal, which ventricular trigger signal causes a ventricular stimulation pulse to be generated;

inhibiting means responsive to said ventricular sensing means for inhibiting said ventricular trigger signal whenever ventricular electrical activity is sensed within a first prescribed time period prior to the generation of said ventricular trigger signal;

timing means for controlling the operation of said atrial and ventricular sensing means in a way that minimizes the likelihood that retrograde atrial electrical activity will trigger a pacer mediated tachycardia.

48. The pacemaker of claim 47 wherein said timing means includes:

means for sensing a premature ventricular contraction (PVC); and

means, responsive to the sensing of a premature ventricular contraction, for preventing the sensing of retrograde atrial electrical activity resulting from said premature ventricular contraction.

49. The pacemaker of claim 48 wherein said means for preventing the sensing of retrograde atrial electrical activity comprises:

means for generating an extended refractory time period subsequent to the sensing of the PVC;

means for sensing atrial electrical activity for an alert time period subsequent to said refractory time period; and

means for generating an A-V interval subsequent to the termination of said alert time period, said ventricular trigger signal being generated by said pulse generating means at the termination of said A-V interval unless inhibited by said inhibiting means.

50. The pacemaker of claim 49 wherein said A-V interval generated by said A-V interval generating means is shortened in response to the sensing of a PVC over what it would be in the absence of sensing a PVC.

51. The pacemaker of claim 49 wherein said alert time period is terminated by the earliest occurrence of either the timing out of said alert time period or the sensing of atrial electrical activity during said alert time period.

52. The pacemaker of claim 47 wherein said timing means includes:

means for sensing a premature ventricular contraction;

means for sensing retrograde atrial activity resulting from said premature ventricular contraction; and

retrograde response means for responding to the sensed retrograde atrial activity in a way that minimizes the likelihood that the retrograde atrial activity will trigger a pacer mediated tachycardia.

53. The pacemaker of claim 52 wherein said retrograde response means comprises

means for generating an atrial escape interval in response to the sensing of said premature ventricular contraction,

means for initiating an atrial alert period immediately subsequent to the sensing of atrial activity, if any, during said retrograde sense period;

means for generating an A-V interval subsequent to the termination of said atrial alert period, if generated, said ventricular trigger signal being generated by said pulse generating means at the termination of said A-V interval unless inhibited by said inhibiting means; and

means for generating an A-V interval subsequent to the termination of said atrial escape interval when no atrial activity is sensed during said retrograde sense period.

54. The pacemaker of claim 53 wherein said atrial alert period, when generated, is terminated by the earliest occurrence of either the timing out of said alert time period or the sensing of atrial electrical activity during said alert time period.

55. The pacemaker of claim 53 wherein said atrial alert period is subdivided in an initial refractory portion and a final alert portion.

56. The pacemaker of claim 53 wherein said A-V interval assumes a first value if atrial activity is sensed during said retrograde sense period and assumes a second value, different from said first value, if atrial activity is not sensed during said retrograde sense period.