Non-invasive hypodermic injection device

• US 4,790,824 A
• Filed: 06/19/1987
• Issued: 12/13/1988
• Est. Priority Date: 06/19/1987
• Status: Expired due to Fees

• Current Assignee: Bioject Incorporated
• Original Assignee: Bioject Incorporated
• Inventors: Morrow, J. Thomas, Burns, Marvin
• Primary Examiner(s): Yasko, John D.
• Application Number:
  US07/064,762
• Time in Patent Office: 543 Days
• Field of Search: 604/68, 604/70, 604/71, 604/72, 604/140, 604/141, 604/143, 604/187, 604/131
• US Class Current: 604/143
• CPC Class Codes: A61M 2005/3132 having flow passages for injection agents at the distal end of the barrel to bypass a sealing stopper after its displacement to this end due to internal pressure increase
• CPC Class Codes: A61M 5/2053 Media being expelled from injector by pressurised fluid or vacuum for infusion A61M5/145, A61M5/155
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules

Abstract

A non-invasive hypodermic injection device includes a two-stage gas delivery system and a medication containing ampule having a truncated hypodermic needle at one end thereof. An ampule shroud encloses the ampule and maintains separation between the truncated hypodermic needle on the ampule and the skin of a patient being injected.

Claims

1. A non-invasive hypodermic injection device, means having a gas charge therein, for injecting a medication through a patient'"'"'s skin, comprising:

a body including;

a first chamber containing the charge;

a valve chamber having an exhaust port and a normally closed valve closing said port, said valve chamber being constructed and arranged to contain the gas charge when same is released from the first chamber and said valve is in its normally closed condition;

a piston chamber operably connected to said port and having a moveable piston therein; and

actuator means for opening said valve, said valve, when open, allowing gas to flow from said valve chamber, through said port, to said piston chamber thereby displacing said piston;

a medication containing ampule including a reservoir for retaining a supply of medication, orifice means located on and extending beyond one end of said reservoir, said orifice means having a passage therein for allowing transit of the medication therethrough, and plunger means, received in siad reservoir, moveable from adjacent the other end of said reservoir towards said orifice means, and including co-action means for moving said plunger with said piston; and

an ampule shroud having an ampule chamber therein for receiving said ampule, said ampule shroud enclosing said ampule, said shroud defining an opening for receiving therein said orifice means, said shroud and said opening being constructed and arranged to maintain a spaced apart relationship between the patient'"'"'s skin and said orifice means during the course of an injection when said shroud is placed against the patient'"'"'s skin.

2. The device of claim 1 wherein said orifice means includes a truncated hypodermic needle fixed to said reservoir and said passage extends through said needle into said reservoir.

3. The device of claim 1 wherein said first chamber has an open top sized to receive a gas-charge containing cartridge having a frangible seal thereon;

and wherein said means for releasing the charge includes a puncture pin at the base of the chamber, said puncture pin being constructed and arranged to puncture the frangible seal of the cartridge, and an end cap sealably received in said open top, said cap including means for pushing the frangible seal over said puncture pin.

4. The device of claim 3 wherein said valve chamber is disposed adjacent said first chamber and wherein said puncture pin includes a hollow passage communicating between said first chamber and said valve chamber.

5. The device of claim 1 wherein said valve is of the poppet type, including a valve diaphragm disposed over said port in said valve chamber, a spring biasing said diaphragm to its normally closed position, a valve shaft affixed to said diaphragm and extending through said port, said shaft being operable with said actuator means to open said valve.

6. The device of claim 5 wherein said actuator means includes an actuator button disposed on the outside of the body, an actuator button shaft extending through the body sidewall and an actuator lever, said lever having a generally L-shaped configuration with the long leg of the L contacting said button shaft and the short leg of the L contacting said valve shaft, said lever being pivotably mounted adjacent the apex of the two legs, said lever being operable, when said button is depressed towards said body, to shift said valve shaft axially thereby opening said valve.

7. The device of claim 6 wherein said long leg has a functional length substantially 8 times as long as that of said short leg, thereby providing a mechanical advantage of 8:

1 for opening said valve.

8. A non-invasive hypodermic injection device, in combination with a pressurized cartridge having a gas charge therein and including a frangible seal, for injecting a medication through a patient'"'"'s skin, comprising:

a body having a cylindrical sleeve and a hollow interior with open ends and a two-stage gas delivery system therein, the first stage of said system including;

a cartridge chamber for receiving the cartridge, including means for releasing the charge contained in the cartridge and;

a valve chamber located adjacent said cartridge chamber in communication therewith, having an exhaust port and including a poppet valve which is biased to a normally closed position covering said port, said chamber being constructed and arranged to contain the gas charge when same is released from said cartridge and said valve is in its normally closed position; and

the second stage of the system including;

an actuator block having a passage therethrough, said passage communicating with said port in said valve chamber;

an actuator lever disposed in said passage; and

means for shifting said lever thereby to open said valve and;

a piston chamber having a piston therein, said chamber communicating with said passage on one side of said piston and;

a medication containing ampule including a reservoir, said reservoir being fillable with a supply of medication, having a shell which has a wall with inner and outer surfaces, said inner surface being characterized by a substantially uniform cross sectional configuration along a defined length portion of said shell, one end of said shell being open and the other end terminating in a receiving portion having orifice means fixedly received therein, said orifice means having a channel therethrough, said channel communicating with said reservoir, and a plunger slideably and sealingly disposed within said defined length portion in said shell, displaceable by said piston between a first position adjacent said open end and a second position adjacent said receiving portion; and

an ampule shroud removably attached to said piston chamber for enclosing said ampule, said shroud including an opening in one end thereof for receiving therein said orifice means, said shroud and said opening being constructed and arranged to maintain a spaced apart relationship between the patient'"'"'s skin and said orifice means during the course of an injection when said one end of said shroud is placed against the patient'"'"'s skin.

9. The device of claim 8 wherein said orifice means includes a truncated hypodermic needle fixed to said reservoir and said channel extends through said needle into said reservoir.

10. The device of claim 8 wherein said cartridge chamber has an open top sized to receive the cartridge;

and wherein said means for releasing the charge includes a puncture pin at the base of the chamber, said puncture pin being constructed and arranged to puncture the frangible seal of the cartridge, and an end cap sealably received in said open top, said cap including means for pushing the frangible seal over said puncture pin.

11. The device of claim 8 wherein said poppet valve includes a valve diaphragm disposed over said port in said valve chamber, a spring biasing said diaphragm to its normally closed position, and a valve shaft affixed to said diaphragm and extending through said port, said shaft being operable with said actuator lever to open said valve.

12. The device of claim 11 wherein said means for shifting said actuator lever includes an actuator button disposed on the outside of the body, and an actuator button shaft extending through the body sidewall, and said actuator lever has a generally L-shaped configuration with the long leg of the L contacting said button shaft and the short leg of the L contacting said valve shaft, said lever being pivotably mounted adjacent the apex of the two legs, said lever being operable, when said button is depressed towards said body, to shift said valve shaft axially thereby opening said valve.

13. A non-invasive hypodermic injection device, means having a gas charge therein, for injecting a medication through a patient'"'"'s skin, comprising:

a body including;

a first chamber containing the gas charge including means for releasing the charge;

a piston chamber selectively, operably connected to said first chamber, and having a movable piston therein;

a medication containing ampule including a reservoir for retaining a supply of medication, orifice means located on one end of said reservoir, said orifice means having a passage therethrough for allowing dispensing of the medication, and plunger means received in said reservoir, moveable from adjacent the other end of said reservoir towards said orifice means, and including co-action means for moving said plunger with said piston; and

an ampule shroud having an ampule chamber therein for receiving said ampule, said shroud defining an opening for receiving therein said orifice means, said shroud and said opening being constructed and arranged to maintain a spaced apart relationship between the patient'"'"'s skin and said orifice means during the course of an injection when said shroud is placed against the patient'"'"'s skin.

14. The device of claim 13 wherein said orifice means includes a truncated hypodermic needle fixed to said reservoir and said passage extends through said needle into said reservoir.

15. The device of claim 13 which further includes a valve chamber having an exhaust port and a normally closed valve closing said port, said valve chamber being constructed and arranged to communicate with said first chamber and to contain the gas charge when same is released and said valve is in its normally closed condition.

16. The device of claim 15 which further includes actuator means for opening said valve, said valve, when open, allowing gas to flow from said valve chamber, through said port, ot said piston chamber thereby displacing said piston.

17. The device of claim 16 wherein said first chamber has an open top sized to receive a gas-charge containing cartridge therein, said cartridge having a frangible seal at one end thereof;

and wherein said means for releasing the charge includes a puncture pin at the base of the chamber, said puncture pin being constructed and arranged to puncture the frangible seal of the cartridge; and

an end cap sealably received in said open top, said cap including means for selectively pushing the frangible seal over said puncture pin.

18. The device of claim 17 wherein said valve chamber is disposed adjacent said first chamber and wherein said puncture pin includes a hollow passage communicating between said first chamber and said valve chamber.

19. The device of claim 15 wherein said valve is of the poppet type, including a valve diaphragm disposed over said port in said valve chamber, a spring biasing said diaphragm to its normally closed position, a valve shaft affixed to said diaphragm and extending through said port, said shaft being operable with said actuator means to open said valve.

20. The device of claim 19 wherein said actuator means includes an actuator button disposed on the outside of the body, an actuator button shaft extending through the body sidewall and an actuator lever, said lever having a generally L-shaped configuration with the long leg of the L contacting said shaft and the short leg of the L contacting said valve shaft, said lever being pivotably mounted adjacent the apex of the two legs, said lever being operable, when said button is depressed towards said body, to shift said valve shaft axially thereby opening said valve.

21. A non-invasive hypodermic injection device, in combination with a pressurized cartridge having a gas charge therein and including a frangible seal, comprising:

a body having a cylindrical sleeve and a hollow interior with open ends and a two-stage gas delivery system therein;

the first stage of said system including;

a cartridge chamber for receiving the cartridge, said cartridge chamber having an open top sized to receive the cartridge and including a puncture pin at the base of the chamber, said puncture pin being constructed and arranged to puncture the frangible seal of the cartridge, and an end cap sealably received in said open top, said cap including an activator shaft threadably received in said cap constructed and arranged to co-act with the cartridge thereby to push the frangible seal onto said puncture pin when said activator shaft is screwed into said cap thereby to release the charge contained in the cartridge; and

a valve chamber located ajacent said cartridge chamber in communication therewith;

having an exhaust port and including a poppet valve which is biased to a normally closed position covering said port, said chamber being constructed and arranged to contain the gas charge when same is released from said cartridge and said valve is in its normally closed position; and

the second stage of the system including;

an actuator block having a passage therethrough, said passage communicating with said port in said valve chamber;

an actuator lever disposed in said passage; and

means for shifting said lever thereby to open said valve; and

a piston chamber having a piston therein, said chamber communicating with said passage on one side of said piston; and

a medication-containing ampule including a reservoir, said reservoir being fillable with a supply of medication, having a shell which has a wall with inner and outer surfaces, said inner surface being characterized by a substantially uniform cross sectional configuration along a defined length portion of said shell, one end of said shell being open and the other end terminating in a receiving portion having a truncated hypodermic needle fixed thereto, said needle having a channel therethrough, said channel communicating with said reservoir, and a plunger slideably and sealingly disposed within said within said defined length portion in said shell, displaceable by said piston between a first position adjacent said open end and a second position adjacent said receiving portion; and

an ampule shroud removably attached to said piston chamber for enclosing, completely, said ampule, said shroud including an opening for receiving therein said needle, said shroud and said opening being costructed and arranged to maintain a spaced apart relationship between the patient'"'"'s skin and said needle means during the course of an injection when said shroud is placed against the patient'"'"'s skin.

22. The device of claim 21 wherein said poppet valve includes a valve diaphragm disposed over said port in said valve chamber, a spring biasing said diaphragm to its normally closed position, a valve shaft affixed to said diaphragm and extending through said port, said shaft being operable with said actuator lever to open said valve.

23. The device of claim 22 wherein said means for shifting said actuator lever includes an actuator button disposed on the outside of the boyd, and an actuator button shaft extending through the body sidewall, and said actuator lever has a generally L-shaped configuration with the long leg of the L contacting said button shaft and the short leg of the L contacting said valve shaft, said lever being pivotably mounted adjacent the apex of the two legs, said lever being operable, when said button is depressed towards said body, to shift said valve shaft axially thereby opening said valve.

24. The device of claim 21 which further includes a supply of medication contained in said ampule.