Multi-size injector port system

• US 4,792,396 A
• Filed: 11/03/1987
• Issued: 12/20/1988
• Est. Priority Date: 11/03/1987
• Status: Expired due to Term

• Current Assignee: Idex Health & Science LLC (RELX PLC)
• Original Assignee: Rheodyne, LLC
• Inventors: Gundelfinger, Richard
• Primary Examiner(s): Levy, Stewart J.
• Assistant Examiner(s): Raevis, Robert R.
• Application Number:
  US07/116,387
• Time in Patent Office: 413 Days
• Field of Search: 73/864.81, 73/864.83-864.87, 73/864.21, 73/863.71-863.73, 73/61.1 C, 422/103, 55/386, 55/67, 55/197, 210/198.2, 210/656
• US Class Current: 210/198.2
• CPC Class Codes: G01N 30/22 in high pressure liquid systems
• CPC Class Codes: G01N 30/6017 Fluid distributors
• CPC Class Codes: G01N 30/6034 joining multiple columns

Abstract

A frame is described, that is part of an injector which is used to load a sample at high pressure into a chromatographic column, wherein a tube coupling hole in the frame can not only couple to a standard 1/16th inch tube, but can also couple to a much smaller diameter tube which is useful for minimizing dispersion when small samples or small chromatographic columns are used. The tube coupling hole has a cylindrical inner end portion of a diameter substantially equal to the smaller tube diameter to closely receive it, a tapered middle portion, and a threaded outer portion. Ferrules for sealing tubes to the tapered hole portion, include a first ferrule having a hole that closely surrounds the smaller diameter tube, with the end of the tube lying in the cylindrical inner end portion. A second ferrule has a hole that closely surrounds the standard size larger tube, the tip of the larger tube lying against the tapered hole portion.

Claims

1. Apparatus for use with a liquid chromatographic analyzing system for coupling not only to a tube of standard-size 1/16th inch outside diameter for usual operation with average to large samples but also to a smaller diameter tube of predetermined smaller outside diameter for operation with small samples with minimum dispersion of the sample, where the outside diameter of the standard-size tube is at least 50% greater than the outside diameter of the smaller diameter tube, comprising:

a frame having a tube coupling hole with an inner end portion which is cylindrical and of a diameter substantially equal to said smaller tube diameter to closely receive and surround an end of said smaller tube, said coupling hole having a larger diameter middle hole portion which can receive and closely surround the end of said standard-size tube with said middle hole portion including a tapered hole region, and said coupling hole having a threaded outer hole portion;

first and second ferrules, each having a tapered forward outside surface which can seal to said tapered hole region, and an inside surface with a cylindrical shape inside that closely receives a different one of said tubes; and

a screw that has an outer portion that can threadably couple to said threaded outer hole portion and an abutting portion that can abut one of said ferrules to press it forwardly.

2. The apparatus described in claim 1 wherein:

said standard-size tube has an outside diameter that is at least twice the diameter of said inner end portion of said coupling hole.

3. The apparatus described in claim 1 wherein:

said screw has a hole which is of a size to closely surround said standard-size tube;

said first ferrule has a hole which closely surrounds said smaller diameter tube, and has a rear portion of about the same outside diameter as said standard-size tube to closely fit into said screw hole, whereby to align said screw and first ferrule.

4. The apparatus described in claim 1 including:

a tube of said standard size extending through said second ferrule and screw and having an extreme tip lying substantially against said tapered middle hole region at a location spaced from said inner end portion of said hole, said screw being threaded into said outer hole portion and said second ferrule being compressed against said tapered hole region.

5. The apparatus described in claim 1 including:

a small diameter tube of said smaller outside diameter extending through said first ferrule and screw and having a forward tube end lying in said inner end portion of said tube coupling hole, said screw being threaded into said outer hole portion and said first ferrule being compressed against said tapered hole region.

6. In a sample injection apparatus which can receive a sample at low pressure and then inject it at high pressure into a chromatographic column device for analysis, the improvement comprising:

an injection apparatus frame having a tube coupling hole with a cylindrical inner hole portion of a first small diameter, a tapered middle hole portion, and a threaded outer hole portion;

a first ferrule which has a hold of a diameter to closely receive a tube of said first small diameter, and a tapered forward portion for sealing to said tapered middle hole portion;

a second ferrule which has a larger hole of a diameter to closely receive a tube of a second diameter that is at least about twice said first diameter, and a tapered forward portion for sealing to said tapered middle hole portion;

a screw which is threadable in said outer hole portion and which can press the forward portion of at least one of said ferrules against said tapered middle hole portion, said screw having a hole which can receive a tube of at least said first diameter;

a first tube with an end portion being of substantially said first diameter, which can lie in a first position in extension through said first ferrule and with an end portion lying in said inner hole portion;

a second tube with a tip, and being of said second diameter, which can lie in a second position in extension through said second ferrule and with said tip lying substantially against said tapered middle hole portion, when said first tube and first ferrule are not in said hole.

7. The improvement described in claim 6 wherein:

said second tube has a diameter of about 1/16th inch and said first tube has a diameter of about 20 thousandths inch.

8. A method for enabling the installation of a second tube of a larger diameter and then a first tube of a smaller diameter in a frame of a chromatographic analyzing system comprising:

forming a tube coupling hole in said frame, with a cylindrical inner hole portion of substantially said first diameter, a tapered middle hole portion, and an outer hole portion;

projecting the end portion of a second tube of said second diameter through a second ferrule, pressing the tip of said second tube against said tapered hole portion at a location spaced outwardly from said inner hole portion, and pressing a tapered forward portion of said second ferrule against said tapered hole portion to seal said second ferrule to said coupling hole and to said second tube;

removing said second tube and second ferrule from said hole;

projecting the end portion of a first tube of said first diameter through a first ferrule, pressing the end portion of said first tube deeply into said inner hole portion and pressing said first ferrule against said tapered hole portion to seal said first ferrule to said coupling hole and to first tube.