Active silicon implant devices

• US 4,793,825 A
• Filed: 09/11/1985
• Issued: 12/27/1988
• Est. Priority Date: 09/11/1984
• Status: Expired due to Fees

• Current Assignee: The secretary of state for defence in her Britannic Majesty's Government of the United Kingdom of Great Britain And Northern Ireland
• Original Assignee: Secretary of State For Defence In Her Britannic Majesty's Government of The United Kingdom and Northern Ireland
• Inventors: White, John C., Mears, Adrian L., Benjamin, John D.
• Primary Examiner(s): Jaworski, Francis J.
• Application Number:
  US06/774,691
• Time in Patent Office: 1,203 Days
• Field of Search: 128/419 PS, 128/630, 128/631, 128/632, 128/635, 128/642, 128/653-654, 128/659-660, 128/736, 128/903, 604/66, 604/140, 604/145, 604/148, 604/131, 604/891, 252/1, 252/600, 374/100, 374/148, 374/178, 324/438
• US Class Current: 604/891.1
• CPC Class Codes: A61B 5/07 Endoradiosondes
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: H01L 27/00 Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate details thereof H01L23/00, H01L29/00 - H10K10/00; assemblies consisting of a plurality of individual solid state devices H01L25/00

Abstract

A medical implant for injecting into the vascular system of animals comprises a device less than 500 μm in size carrying signal processing means for providing an output in response to an input signal. The input may be acoustic, electromagnetic, temperature, pH value, or chemical. The output may be acoustic, electromagnetic, or chemical. Large numbers, e.g., 10⁸, of the implant devices may be mixed into a saline solution and injected into a blood vessel where they are carried around the vascular system, or the devices may be mixed with a gas and inhaled. The amount of circulation depends on the device size. For the larger device e.g., above 7 μm to around 250 μm, circulation will be short lived. Smaller sized e.g., <3 μm devices will circulate for a considerable time. Anti-bodies may be coated onto the devices to cause them to adhere to target areas such as tumors. In one device a chemical is released when illuminated externally by an acoustic beam. In another device a chemical is released when the pH of surrounding blood changes to a given level. Power to operate the device may be by an integral battery.

Claims

1. An intravascular implant comprising a plurality of microelectronic devices each encapsulating a pharmaceutical compound or composition and each having a maximum dimension of less than 500 μ

m and adapted to pass through a body along blood vessels in large numbers, each device incorporating signal processing means for providing an output in response to an input signal, said output of said signal processing means causing rupture of said device and release of said pharmaceutical compound or composition into said body.

2. The implant of claim 1 wherein said devices are less then 7 μ

m in maximum dimension.

3. The implant of claim 2 wherein each device includes piezo electric material and rectifying means cooperating with said piezo electric material for generating an electric signal.

4. The implant of claim 1 wherein said devices are less than 3 μ

m in maximum dimension.

5. The implant of claim 1 wherein said input signal is acoustic.

6. The implant of claim 1 wherein said input signal is electromagnetic.

7. The implant of claim 1 wherein said input signal is representative of temperature.

8. The implant of claim 7 wherein said signal processing means includes a diode having electrical characteristics which vary with temperature and thereby provide said input signal representative of temperature.

9. The implant of claim 1 wherein said input signal is representative of pH value.

10. The implant of claim 9 wherein said signal processing means includes a chemically sensitive field effect transistor for measuring pH values thereby providing said input signal representative of pH value.

11. The implant of claim 1 wherein the input signal is chemical.

12. The implant of claim 1 wherein the output is acoustic.

13. The implant of claim 1 wherein the output is electromagnetic.

14. The implant of claim 1 wherein the output is chemical.

15. The implant of claim 1 wherein each device includes a battery.

16. The implant of claim 1 wherein each device further comprises an antibody coating.

17. A pharmaceutical preparation comprising a plurality of semiconductor devices in a pharmaceutically acceptable carrier or diluent, each device having a maximum dimension less than 500 μ

m and encapsulating a pharmaceutical compound or composition and adapted to pass along blood vessels in large numbers, said devices each including signal processing means for providing an output in response to an input signal, each said device having a frangible part which is capable of rupturing to release said pharmaceutical compound or compositon from each said device on receipt of said output from each said signal processing means.

18. The preparation of claim 17 wherein each device comprises a chemically sensitive field effect transistor for measuring pH values to provide said input signal.

19. The preparation of claim 17 wherein said signal processing means includes a diode for measuring temperature to provide said input signal.

20. A method of treating the animal or human body comprising administering a pharmaceutical preparation into the vascular system in an amount effective to treat the body, said pharmaceutical preparation comprising a plurality of semiconductor devices in a pharmaceutically acceptable carrier or diluent, each device having a maximum diameter less than 500 μ

m and encapsulating a pharmaceutical compound or composition and adapted to pass along blood vessels in large numbers, each of said devices including signal processing means for providing an output in response to an input signal, each of said devices having a frangible part which is capable of rupturing to release said pharmaceutical compound or composition on receipt of said output from each said signal processing means.

21. The method of claim 20 wherein the body is selectively subject to electromagnetic, or ionizing radiation, or acoustic energy to provide said input signal to said signal processing means to obtain release of said pharmaceutical compound or composition in a selected part of said body.

22. A method of detecting a body function in an animal or human body comprising the steps of:

inserting or inhaling into a body part a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent containing a plurality of intravascular devices, each device having a maximum dimension less than 500 microns and adapted to pass along blood vessels, each device including signal processing means for providing an output in response to an input signal;

providing an input signal to each said intravascular device; and

obtaining an output response from at least a plural subset from among the plurality of intravascular devices.

23. The method of claim 22 wherein the body is selectively subjected to an electromagnetic or ionizing radiation, or acoustic energy to provide said input signal.

24. The method of claim 22 wherein said intravascular devices are subject to a temperature, pH or chemical range to provide said input signal.

25. The method of claim 22 wherein said output is acoustic, electromagnetic, or chemical.

26. The method of claim 22 wherein said pharmaceutically acceptable carrier is a volatile liquid wherein said step of inhaling includes the step of administering by inhalation as a gas.

27. A method of delivering a drug substance to a predetermined body site of an animal or a human body comprising the steps of:

administering to said animal or human a pharmaceutical composition of a pharmaceutical carrier or diluent containing an intravascular microdisc device having a maximum dimension less than 500 microns adapted to pass along blood vessels, said device including said drug substance, and signal processing means for releasing said drug substance in response to an input signal; and

providing said input signal thereby releasing said drug substance for said intravascular device.

28. The delivery method of claim 27 wherein said input signal is electromagnetic, or ionizing radiation, or acoustic energy.