Controlled delivery device

• US 4,793,997 A
• Filed: 06/29/1987
• Issued: 12/27/1988
• Est. Priority Date: 03/28/1985
• Status: Expired due to Fees

• Current Assignee: Northern Telecom Limited (Nortel Networks Corporation)
• Original Assignee: Standard Telephones and Cables Public Limited Company
• Inventors: Drake, Cyril F., Arch, Alfred J.
• Primary Examiner(s): Robinson, Ellis P.
• Assistant Examiner(s): Ryan, P. J.
• Application Number:
  US07/068,787
• Time in Patent Office: 547 Days
• Field of Search: 514/770, 514/962, 424/457, 424/9, 424/426, 501/45, 252/408.1, 428/321.5, 428/35, 428/36, 428/426
• US Class Current: 424/426
• CPC Class Codes: A61K 9/0092 Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
• CPC Class Codes: A61K 9/2813 Inorganic compounds
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: Y10T 428/131 Glass, ceramic, or sintered, fused, fired, or calcined metal oxide or metal carbide containing [e.g., porcelain, brick, cement, etc.]
• CPC Class Codes: Y10T 428/1317 Multilayer [continuous layer]
• CPC Class Codes: Y10T 428/249997 Encapsulated liquid

Abstract

A device for the controlled release of an active material into an aqueous medium, e.g. body fluids, comprises a water soluble glass container in which the active material is sealed. The container wall has a region of reduced thickness which region dissolves before the remainder of the container wall to release the active material.

Claims

1. A device for the timed release of an active material into an aqueous medium, the device comprising a sealed container having a wall consisting of a water soluble glass and in which container the active material is encapsulated, wherein a minor proportion of container wall consists of a region of reduced resistance to solution attack whereby, when the device is contacted by the aqueous medium, that region is dissolved over a predetermined time period to provide an opening in the container wall so as to release the active material whilst the remainder of the glass container wall is only partially dissolved so as to prevent collapse of the container.

2. A device as claimed in claim 1, wherein the reduced resistance region comprises a region of reduced wall thickness.

3. A device as claimed in claim 2, wherein said reduced thickness region comprises a groove provided in the device wall.

4. A device as claimed in claim 1, wherein the glass is a phosphorus pentoxide glass.

5. A device as calimed in claim 1, wherein the glass is a phosphorus pentoxide glass.

6. A device as claimed in claim 4, wherein said glass includes a modifying oxide selected from the group comprising calcium oxide, zinc oxide and mixtures thereof.

7. A device for the timed release of an active material into an aqueous medium, the device comprising a sealed tubular container having a wall consisting of a water soluble glass and in which container the active material is encapsulated, wherein the container wall has cylindrical inner and outer major surfaces, the two cylindrical surfaces being non co-axial so as to provide a region of reduced thickness in the container wall whereby, when the device is contacted by the aqueous medium, the region of reduced wall thickness is dissolved to provide an opening in the container wall so as to release the active material whilst the remainder of the container wall is only partially dissolved so as to prevent collapse of the container.