System activity change indicator

• US 4,794,533 A
• Filed: 11/07/1986
• Issued: 12/27/1988
• Est. Priority Date: 11/07/1986
• Status: Expired due to Term

• Current Assignee: Aequitron Medical, Inc. (Medtronic Plc)
• Original Assignee: CNS Incorporated (GSK plc)
• Inventors: Cohen, Daniel E.
• Primary Examiner(s): Smith, Jerry
• Assistant Examiner(s): MACDONALD, ALLEN R
• Application Number:
  US06/928,522
• Time in Patent Office: 781 Days
• Field of Search: 364/417, 364/483, 364/485, 128/731, 324/77 A
• US Class Current: 600/544
• CPC Class Codes: A61B 5/372 Analysis of electroencephalograms
• CPC Class Codes: A61B 5/377 using evoked responses

Abstract

A system for measuring changes in the number of maxima and minima occurring in a signal over time which changes indicate activity changes in a subject from which the signal measured is obtained.

Claims

1. A method for determining activity changes occurring in a system as these activity changes are represented in at least one signal representing system activity, said method comprising:

acquiring a first sequence of consecutive samples of amplitude values of said system activity signal taken at a rate sufficient to represent those portions of said system activity signal related to said activity changes, said samples in said first sequence being acquired over a selected duration of time established with respect to a selected point in time;

determining which relative magnitude relationship occurs from among first, second and third relative magnitude relationships between each sample in said first sequence and its immediately neighboring samples on either side thereof excepting those samples occurring first and last in said first sequence;

forming a second sequence of decision numbers with each such decision number therein having a one-to-one correspondence with a said sample in said first sequence excepting those samples occurring first and last in said first sequence, each said decision number having one of a first selected set of values if its said corresponding sample in said first sequence has relative magnitude relationships with each of its immediately neighboring samples on either side thereof which are identical, but having one of a second selected set of values if its corresponding sample in said first sequence has relative magnitude relationships with each of its immediately neighboring samples on either side thereof which differ; and

providing an indication of said activity changes based on said decision numbers.

2. The apparatus of claim 1 wherein said system activity signal is an electroencephalographic signal.

3. The method of claim 1 wherein said forming of a second sequence is followed by forming a third sequence of index numbers with each such index number corresponding to a said decision number in said second sequence, each said index number having a value equal to a selected first arithmetical combination of those decision numbers in a selected subsequence of decision numbers which include that decision number to which that said index number corresponds, and providing an indication of said activity changes based on said index numbers.

4. The method of claim 3 wherein said selected subsequence of decision numbers is formed of consecutive decision numbers with approximately an equal number of decision numbers therein on either side of said decision number to which said index number corresponds.

5. The method of claim 4 wherein selected ones of those decision numbers in said selected subsequence thereof have those values established therefor in forming said second sequence reduced before forming said selected first arithmetical combination of said decision numbers to form an index number with those said selected ones of such decision numbers farther from said decision number corresponding to said index number being reduced more.

6. The method of claim 5 wherein those steps of said acquiring of a first sequence, said determining of relative magnitude relationships, said forming of a second sequence, and said forming of a third sequence are initial steps and are repeated with respect to said system at a selected point in time to form a first set of repeat steps which are followed by forming a selected second arithmetical combination of each said index number in said initial steps with its corresponding index number in said first set of repeat steps, and providing an indication of said activity changes based on said selected second arithmetical combination.

7. The method of claim 3 wherein selected ones of those decision numbers in said selected subsequence thereof have those values established therefor in forming said second sequence changed before forming said first selected arithmetical combination of said decision numbers to form an index number.

8. The method of claim 3 wherein those steps of said acquiring of a first sequence, said determining of relative magnitude relationships, said forming of a second sequence, and said forming of a third sequence are initial steps and are repeated with respect to said system at a selected point in time to form a first set of repeat steps which are followed by forming a selected second arithmetical combination of each said index number in said initial steps with its corresponding index number in said first set of repeat steps, and providing an indication of said activity changes based on said selected second arithmetical combination.

9. The apparatus of claim 3 wherein said system activity signal is an electroencephalographic signal.

10. A detection system for determining activity changes occurring in a subject system as these activity changes are represented in at least one signal representing subject system activity, said detection system comprising:

a signal acquiring means for acquiring said system activity signal;

an analog-to-digital converter means for providing a first sequence of consecutive digitized samples of amplitude values of said system activity signal;

a signal processing means for forming a second sequence of decision numbers with each such decision number therein having a one-to-one correspondence with a said sample in said first sequence excepting those samples occurring first and last in said first sequence, each said decision number having one of a first selected set of values if its said corresponding sample in said first sequence has relative magnitude relationships with each of its immediately neighboring samples on either side thereof which are identical, but having one of a second selected set of values if its corresponding sample in said first sequence has relative magnitude relationships with each of its immediately neighboring samples on either side thereof which differ; and

a display means for providing an indication of said activity changes based on said decision numbers.

11. The system of claim 10 wherein said system activity signal is an electroencephalographic signal.

12. The system of claim 10 wherein said signal processing means if further capable of forming a third sequence of index numbers with each such index number corresponding to a decision number in said second sequence, each said index number having a value equal to a selected arithmetical combination of those decision numbers in a selected subsequence of decision numbers which include that decision number to which that said index number corresponds, and said display means provides an indication of said activity changes based on said index numbers.

13. The system of claim 12 wherein said signal processing means comprises a first, a second and a third register, each for storing a said digitized sample, said first register receiving consecutively and storing temporarily therein each said digitized sample provided by said analog-to-digital converter means and transferring to said second register for temporary storage therein that digitized sample immediately preceding each said digitized sample currently between received thereby, said second register receiving consecutively and storing temporarily therein said digitized samples transferred from said first register and transferring to said third register for temporary storage therein that digitized sample immediately preceding each said digitized sample currently being received thereby, said third register receiving consecutively and storing temporarily therein said digitized samples transferred from said second register, and wherein said system further comprises first and second comparator means each for comparing values of said digitized samples provided thereto and providing signals at an output thereof indicating whether one of those digitized samples has a value which is greater than, less than or equal to that of that other one provided thereto, said first comparator means being connected to said first and second registers to receive representations of those said digitized samples currently being stored in each for comparison, said second comparator means being connected to said second and third registers to receive representations of those said digitized samples currently being stored in each for comparison, and wherein said signal processing means further comprises a logic means for determining whether signals provided thereto are identical or differ and of providing signals at an output thereof indicating which condition is currently occurring, said logic means being electrically connected to said outputs of each of said first and second comparator means, and wherein said signal processing means further contains a first shift register means for receiving current signal portions at an input thereof for temporary storage therein and shifting each such signal portion along storage sites therein as each successive current signal portion is received at said input with said first shift register means input being electrically connected to said logic means output, each of said storage sites having a storage site output to which it is connected.

14. The system of claim 13 wherein said system further comprises a subsequence selector means connected to each of said storage site outputs and for receiving and storing temporarily said signal portions and making them available at least at one output thereof, and wherein said system further comprises an arithmetical combining means for performing arithmetic operations on signal portions provided thereto at at least one input thereof, said arithmetical combining means input being electrically connected to said subsequences selector means output.

15. The system of claim 10 wherein said signal processing means comprises a computer means.

16. The system of claim 15 wherein said signal processing means comprises a memory means for storing, at least temporarily, said digitized samples provided by said analog-to-digital converter means, a comparator means for comparing values of selected ones of said digitized samples stored in said memory means and of providing indications of which of selected digitized samples compared have values greater than, less than or equal to that selected other to which it is compared, logic means for providing indications of which of selected said indications provided by said comparator means are identical to or differ from other selected said indications provided by said comparator means, and a storage means for storing, at least temporarily, selected said indications of said logic means.

17. The system of claim 10 wherein said signal processing means comprises a memory means for storing, at least temporarily, said digitized samples provided by said analog-to-digital converter means, a comparator means for comparing values of selected ones of said digitized samples stored in said memory means and of providing indications of which of said selected digitized samples compared have values greater than, less than or equal to those values of selected others of said digitized samples stored in said memory means to which it is compared, logic means for providing indications of which of selected said indications provided by said comparator means are identical to or differ from other selected said indications provided by said comparator means, and a storage means for storing, at least temporarily, selected said indications of said logic means.

18. The system of claim 17 wherein said signal processing means comprises a first, a second and a third register, each for storing a said digitized sample, said first register receiving consecutively and storing temporarily therein each said digitized sample provided by said analog-to-digital converter means and transferring to said second register for temporary storage therein that digitized sample immediately preceding each said digitized sample currently being received thereby, said second register receiving consecutively and storing temporarily therein said digitized samples transferred from said first register and transferring to said third register for temporary storage therein that digitized sample immediately preceding each said digitized sample currently being received thereby, said third register receiving consecutively and storing temporarily therein said digitized samples transferred from said second register, and wherein said system further comprises first and second comparator means each for comparing values of said digitized samples provided thereto and providing signals at an output thereof indicating whether one of those digitized samples has a value which is greater than, less than or equal to that of that other one provided thereto, said first comparator means being connected to said first and second registers to receive representations of those said digitized samples currently being stored in each for comparison, said second comparator means being connected to said second and third registers to receive representations of those said digitized samples currently being stored in each for comparison, and wherein said signal processing means further comprises a logic means for determining whether signals provided thereto are identical or differ and of providing signals at an output thereof indicating which condition is currently occurring, said logic means being electrically connected to said outputs of each of said first and second comparator means, and wherein said signal processing means further contains a first shift register means for receiving current signal portions at an input thereof for temporary storage therein and shifting each such signal portion along storage sites therein as each successive current signal portion is received at said input with said first shift register means input being electrically connected to said logic means output, each of said storage sites having a storage site output to which it is connected.

19. The system of claim 10 wherein said signal processing means comprises a first, a second and a third register, each for storing a said digitized sample, said first register receiving consecutively and storing temporarily therein each said digitized sample provided by said analog-to-digital converter means and transferring to said second register for temporary storage therein that digitized sample immediately preceding each said digitized sample currently being received thereby, said second register receiving consecutively and storing temporarily therein said digitized samples transferred from said first register and transferring to said third register for temporary storage therein that digitized sample immediately preceding each said digitized sample currently being received thereby, said third register receiving consecutively and storing temporarily therein said digitized samples transferred from said second register, and wherein said system further comprises first and second comparator means each for comparing values of said digitized samples provided thereto and providing signals at an output thereof indicating whether one of those digitized samples has a value which is greater than, less than or equal to that of that other one provided thereto, said first comparator means being connected to said first and second registers to receive representations of those said digitized samples currently being stored in each for comparison, said second comparator means being connected to said second and third registers to receive representations of those said digitized samples currently being stored in each for comparison, and wherein said signal processing means further comprises a logic means for determining whether signals provided thereto are identical or differ and of providing signals at an output thereof indicating which condition is currently occurring, said logic means being electrically connected to said outputs of each of said first and second comparator means, and wherein said signal processing means further contains a first shift register means for receiving current signal portions at an input thereof for temporary storage therein and shifting each such signal portion along storage sites therein as each successive current signal portion is received at said input with said first shift register means input being electrically connected to said logic means output, each of said storage sites having a storage site output to which it is connected.

20. The system of claim 19 wherein said system further comprises a subsequence selector means connected to each of said storage site outputs and for receiving and storing temporarily said signal portions and making them available at least at one output thereof, and wherein said system further comprises an arithmetical combining means for performing arithmetic operations on signal portions provided thereto at at least one input thereof, said arithmetical combining means input being electrically connected to said subsequence selector means output.