Magnetic-polymer particles
First Claim
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1. A process for the preparation of magnetic-polymer particles comprising the steps of:
- (a) combining a first aqueous solution of at least two species of transition metal ions capable of reacting with each other to form a magnetic precipitate and a polymer having available coordination sites in proportions adapted to produce a resuspendable product;
(b) reacting said transition metal ions in the presence of said polymer to form a magnetic precipitate comprising magnetic-polymer particles;
(c) recovering said magnetic-polymer particles.
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Abstract
A magnetic-polymer particle, useful in immunoassay techniques and various other biological/medical applications is produced by coprecipitation of transition metals in the presence of a polymer having available coordination sites. These particles are capable of forming stable aqueous suspensions and may be easily resuspended after agglomeration.
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Citations
44 Claims
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1. A process for the preparation of magnetic-polymer particles comprising the steps of:
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(a) combining a first aqueous solution of at least two species of transition metal ions capable of reacting with each other to form a magnetic precipitate and a polymer having available coordination sites in proportions adapted to produce a resuspendable product; (b) reacting said transition metal ions in the presence of said polymer to form a magnetic precipitate comprising magnetic-polymer particles; (c) recovering said magnetic-polymer particles. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 27, 31, 37, 38, 39)
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- 22. A resuspendable magnetic-polymer particle comprising a particulate, magnetic reaction product of a water-soluble form of iron and a water-soluble polymer having available coordination sites.
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28. A process for the preparation of ferromagnetic-polymer particles comprising the steps of:
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(a) preparing an aqueous solution of iron capable of reacting to form a magnetic precipitate and a polymer having available coordination sites; (b) adding a stoichiometric excess of a strong base; (c) agitating said solution; (d) allowing the magnetic-polymer particles to precipitate; (e) recovering said magnetic-polymer particles. - View Dependent Claims (29, 30)
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32. A process for the assay of a predetermined species comprising the steps of:
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(a) preparing an aqueous solution of transition metal ions capable of reacting to form a magnetic precipitate and a polymer having available coordinate sites in proportions adapted to produce resuspendable particles; (b) reacting said metal ions in the presence of said polymer to form a magnetic precipitate comprising magnetic-polymer particles; (c) recovering said magnetic-polymer particles; (d) resuspending said magnetic-polymer particles in an aqueous solution; (e) reacting said magnetic-polymer particles with both a bifunctional compound adapted to form primarily extra-particulate bonds, and a biofunctional ligand, said biofunctional ligand being specific in its ability to bond with said predetermined species; (f) exposing a mixture containing an unknown quantity of said predetermined species to a suspension of said magnetic-polymer particles containing said biofunctional ligand, thereby causing said biofunctional ligand to bond to said predetermined species; (g) passing said mixture through a magnetic filter having a magnetic field, said filter adapted to retain said magnetic-polymer particles; (h) removing said magnetic field from said filter and eluting said retained magnetic-polymer particles; (i) analyzing said eluted magnetic-polymer particles to provide desired data relative to said predetermined species. - View Dependent Claims (33, 34, 35, 36, 40, 41, 42, 43)
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44. A process for the preparation of magnetic-polymer particles comprising the steps of:
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(a) combining a first aqueous solution comprising at least two species of transition metal ions capable of reacting with each other to form a magnetic precipitate, and a polymer having biofunctional activity and having available coordination sites in proportions adapted to produce a resuspendable precipitate product having biofunctional activity; (b) reacting said transition metal ions in the presence of said polymer to form a magnetic precipitate comprising a complex of said metal and said biofunctional polymer; (c) recovering said magnetic precipitate from said first solution.
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Specification