Integrated drug dosage form and metering system

• US 4,797,283 A
• Filed: 09/23/1987
• Issued: 01/10/1989
• Est. Priority Date: 11/18/1985
• Status: Expired due to Term

• Current Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Original Assignee: Biotrack, Inc. (Novartis Ag)
• Inventors: Stroy, Gary H., Mungall, Dennis R., Ostoich, Vladimir E., Allen, Jimmy D., Hillman, Robert S., Cobb, Michael E.
• Primary Examiner(s): Lesmes, George F.
• Assistant Examiner(s): HORNE, LEON
• Application Number:
  US07/100,123
• Time in Patent Office: 475 Days
• Field of Search: 424/443, 424/444, 424/448, 424/449, 424/484, 424/486
• US Class Current: 424/443
• CPC Class Codes: A61J 7/0076 Medicament distribution means with pill counting devices A61J7/02; with time indication A61J7/04; containers or packages with special means for dispensing contents B65D83/00
• CPC Class Codes: A61J 7/0418 with electronic history memory
• CPC Class Codes: A61J 7/0445 for preventing drug dispensing during a predetermined time period
• CPC Class Codes: A61J 7/0481 working on a schedule basis
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence
• CPC Class Codes: B65H 35/006 with means for delivering a predetermined length of tape
• CPC Class Codes: G04G 15/006 for operating at a number of different times cigar or cigarette receptacles or boxes with means for limiting the frequency of smoking A24F15/005
• CPC Class Codes: Y10T 83/4455 Operation initiated by work-driven detector means to measure work length
• CPC Class Codes: Y10T 83/889 Tool with either work holder or means to hold work supply
• CPC Class Codes: Y10T 83/896 Rotatable wound package supply

Abstract

An automatic drug tape dispensing and metering device and a roll of drug tape housed in a small portable dispenser unit. The dispenser contains a measurement device for carefully measuring the length of tape as it is dispensed from the dispenser. A counter monitors the remaining doses of drug tape remaining within the dispenser. A timer device may be provided to alert the patient that it is time for the medicament to be dispensed. As the lid of the dispenser unit is opened, the measured length of drug tape is severed from the roll by a cutter blade incorporated into the lid. The device permits a physician to accurately customize the dosage and administration of the medicament to be given a patient by adjusting the tape length released for each single dose and selecting the time intervals between dosages.

Claims

1. An ingestable medicament tape, comprising:

about 10 to 40 weight % of a physiologically acceptable thermoplastic polymer selected from the group consisting of polyvinylpyriolidone, hydroxypropylmethylcellulose, and hydroxypropycellulose;

about 15 to 50 weight % of a polysaccharide;

about 5 to 40 weight % of a compatible physiologically acceptable plasticizer; and

about 0 to 20 weight % sorbitol;

said ingestable medicament tape being capable of being fed from a roller and cut at preselected lengths to provide a predetermined medicament dosage, having a tensile strength of at least 200 psi, and containing from 0.01 to 2 mg drug/mm³.

4. A tape according to claim 1, wherein said polysaccharide is starch.

5. A tape according to claim 1, wherein said thermoplastic polymer is polyvinylpyrrolidone.

6. A tape according to claim 1, having a thickness in the range of about 2 mil to 20 mil, and a width in the range of about 0.25 to 1 cm.

7. A tape according to claim 6, wherein said plasticizer is triethyl citrate.

8. A tape according to claim 6, wherein said plasticizer is 1,2-propylene glycol.

2. An ingestable medicament tape, comprising:

about 10 to 20 weight % hydroxypropylcellulose;

about 30 to 50 weight % starch;

about 5 to 20 weight % of a physiologically compatible plasticizer; and

about 7.5 to 20 weight % of sorbitol;

said ingestable medicament tape being capable of being fed from a roll and cut at preselected lengths to provide a predetermined medicament dosage, having a tensile strength of at least 250 psi, and containing from 0.01 to 2 mg drug/mm³.

3. An ingestable medicament tape, comprising:

about 10 to 15 weight % of hydroxypropylcellulose;

about 32 to 45 weight % starch;

about 10 to 20 weight % triethylcitrate; and

about 10 to 15 weight % sorbitol;

said ingestable medicament tape capable of being fed from a roll and cut at preselected lengths to provide a predetermined medicament dosage;

having a tensile strength of at least about 300 psi, a thickness of from about 2 to about 20 mil, and a width in the range of about 0.25 to 1 cm;

containing from 0.01 to 2 mg drug/mm³ ; and

exhibiting less than about 5% dimensional change due to ambient variations in temperature and humidity.

9. A tape according to claim 3, produced by formation at an elevated temperature.

10. A tape according to claim 9, produced by extrusion.

11. A digestable medicament tape capable of being fed from a roll and cut at preselected lengths providing a predetermined medicament dosage, having a tensile strength of at least about 250 psi, a thickness of from about 2 to 12 mil, from about 0.01 to 2 mg drug/mm³ and less than about a 5% dimensional change due to ambient variations in temperature and humidity.