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Living cells encapsulated in crosslinked protein

  • US 4,798,786 A
  • Filed: 05/06/1982
  • Issued: 01/17/1989
  • Est. Priority Date: 05/06/1982
  • Status: Expired due to Fees
First Claim
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1. A process for the encapsulation of living cells which comprises:

  • (a) dispersing living cells in an aqueous solution of a capsule wall-forming protein;

    (b) forming aqueous droplets of said cell-containing dispersion in an aqueous-immiscible, cell compatible continuous processing medium;

    (c) crosslinking said protein with a crosslinking agent which is soluble in said continuous processing medium but substantially insoluble in said aqueous droplets thus forming crosslinked capsules, and adding to the formed crosslinked capsules a capsule wall degradation enzyme for a time sufficient to enlarge pore sizes in said walls to a predetermined average size.

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