Platelet collection system
First Claim
1. An apparatus for selectively separating platelets from whole blood comprising:
- a receptacle means defining a receptacle for receiving said whole blood, said receptacle means being formed including at least a first porous membrane having a blood contacting surface and an opposite outer surface, said porous membrane having a porosity sufficiently small enough to inhibit the passage of said platelets;
a first valve means for selectively directing said whole blood into said rectacle;
a pressure regulating means selectively operable for establishing a pressure differential across said porous membrane sufficient enough to draw substantially only water through said porous membrane and for terminating said pressure differential, whereby said platelets become concentrated in a boundary layer formed adjacent said porous membrane blood contacting surface when said pressure differential is established and can be flushed free upon termination of said pressure differ.
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Accused Products
Abstract
A system is provided for collecting platelets. Whole blood is removed from a patient 10 and directed to a hemoconcentrator 22 having a blood inlet 24, a blood outlet 26, a blood passage communicating with the blood inlet and blood outlet, an ultrafiltrate outlet 28 and a membrane separating the blood passage from the ultrafiltrate outlet. The blood is passed through the blood passage of the hemoconcentrator while a negative pressure is adapted to the ultrafiltrate outlet. In this manner, the platelets concentrate on the membrane wall. After a selected period of time, the application of the negative pressure is terminated to the ultrafiltrate outlet, and the concentrated platelets from the hemoconcentrator are flushed and directed to a platelet collection container 44. In one embodiment, the flushing solution comprises the patient'"'"'s blood that is directed via the blood inlet through the blood passage while in another embodiment, the patient'"'"'s blood is diverted and a saline solution is used as the flush. During the flush, a positive pressure may be applied to the ultrafiltrate outlet of the hemoconcentrator.
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Citations
22 Claims
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1. An apparatus for selectively separating platelets from whole blood comprising:
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a receptacle means defining a receptacle for receiving said whole blood, said receptacle means being formed including at least a first porous membrane having a blood contacting surface and an opposite outer surface, said porous membrane having a porosity sufficiently small enough to inhibit the passage of said platelets; a first valve means for selectively directing said whole blood into said rectacle; a pressure regulating means selectively operable for establishing a pressure differential across said porous membrane sufficient enough to draw substantially only water through said porous membrane and for terminating said pressure differential, whereby said platelets become concentrated in a boundary layer formed adjacent said porous membrane blood contacting surface when said pressure differential is established and can be flushed free upon termination of said pressure differ. - View Dependent Claims (2, 3, 4)
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5. An apparatus for connection in an extracorporeal circuit for selectively separating platelets from whole blood comprising:
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a hemoconcentrator having a blood passageway defined therethrough, said blood passageway having a blood inlet end and an opposite blood outlet end, said blood passageway being defined by at least one porous membrane having a first blood contacting surface and a second opposite surface which communicates with another outlet port, said porous membrane having a porosity sufficiently small enough to inhibit the passage of said platelets; a first valve means for receiving said whole blood which is selectively operable for directing said whole blood through said blood passageway and through other components connected in said extracorporeal circuit; a pressure regulating means being selectively operable for establishing at least two different pressure differential states across said porous membrane, a first of said states being sufficient enough to draw substantially only water through said membrane whereby said platelets become concentrated along said membrane blood contacting surface, while a second of said states being sufficient to promote the flushing of said platelets away from said blood contacting surface. - View Dependent Claims (6, 7, 8, 9)
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10. A method of collecting platelets from whole blood from a patient comprising:
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obtaining said whole blood from said patient; selectively transporting said whole blood through a passageway defined by at least a first porous membrane; selectively removing substantially only water from a boundary layer formed adjacent said porous membrane to concentrate said platelets; and flushing said concentrated platelets from said boundary layer. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification