Apparatus for generating multiphasic defibrillation pulse waveform

• US 4,800,883 A
• Filed: 04/02/1986
• Issued: 01/31/1989
• Est. Priority Date: 04/02/1986
• Status: Expired due to Term

• Current Assignee: Intermedics Incorporated
• Original Assignee: Intermedics Incorporated
• Inventors: Winstrom, William L.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US06/847,283
• Time in Patent Office: 1,035 Days
• Field of Search: 128/419 D
• US Class Current: 607/7
• CPC Class Codes: A61N 1/3906 characterised by the form of the shockwave
• CPC Class Codes: A61N 1/3956 Implantable devices for applying electric shocks to the heart, e.g. for cardioversion

Abstract

An apparatus suitable for use in an implantable automatic defibrillation system for automatically generating a multiphasic defibrillation pulse waveform in response to sensed fibrillation has first and second series charge-storing capacitors having a common terminal and two other terminals each at different potentials. A controller senses cardiac fibrillation and generates a control signal which causes a charging circuit to charge the capacitors to selected voltage levels in sequentially alternating charge generation and charge coupling cycles. A voltage level detector senses the stored voltage level, disables the charging circuit when the sensed voltage reaches a predetermined level, and informs the controller that the capacitors are fully charged. The controller then communicates control signals indicative of pulse magnitude, duration, and polarity to a multiphasic pulse generator having a number of high-power switches and corresponding switch drivers interposed in circuit between the heart and the terminals of the charge-storing capacitors. The drivers control the conduction states of the switches according to the control signals to establish selected circuit paths between the three terminals and the heart, and to thereby deliver to the heart a multiphasic waveform having pulses with the selected parameters of magnitude, duration, and polarity.

Claims

1. An apparatus for generating multiphasic defibrillation pulse waveforms by selectively switching the continuous output of a single multilevel source, comprising:

first and second output terminal means for electrical connection to the heart;

a plurality of charge storage means forming a single multilevel source, each said storage means storing an electrical charge to provide an output potential;

low voltage power source means;

charging means connected to said plurality of charge storage means and said low voltage power source means for charging each of said charge storage means to a level suitable to cause defibrillation of the heart;

a plurality of switch means, each having control means operative to render the switch means conductive in response to a control signal, one switch means of said plurality being connected in circuit between a respective one of each said charge storage means and each of said first and second output terminal means for connecting the potential provided by the said charge storage means to the respective terminal means when said switch means is conductive sand disconnecting the potential provided by said charge storage means form the respective terminal means when said switch means is nonconductive; and

pulse generator means connected to said control means of said plurality of switch means for applying control signals to said control means upon said charge storage means reaching a predetermined level to thereby control the conductive state of each of said plurality of switch means to sequentially connect and disconnect said output potentials of said plurality of charge storage means to and from said first and second output terminal means in selected additive and subtractive combinations to generate a multiphasic defibrillation pulse waveform for application to the heart.

2. The apparatus of claim 1 further comprising:

means responsive to the attainment by at least one of said plurality of charge storage means of a predetermined level of charge

for disabling said charging means from further charging of said charge storage means; and

means responsive to the attainment by said at least one of said plurality of charge storage means of said predetermined level of charge for enabling said pulse generator means to generate said multiphasic pulse waveform.

3. The apparatus of claim 2 wherein said means responsive to the attainment of a predetermined level of charge comprises:

means for receiving signals indicative of said predetermined level of charge;

means for producing from said signals a first scaled reference level;

means for detecting the valve of charge stored in at least one of said charge storage means;

means for producing from the detected level of charge a second scaled level indicative of said level of charge;

means for comparing said second scaled level with said first scaled reference level; and

means responsive to said means for comparing for disabling said charging means when aids second scaled level attains at least the level of said first scaled reference level.

4. The apparatus of claim 1 wherein said charging means comprises:

charge generation means for generating an electrical charge during a charge generation cycle;

charge coupling means for coupling said electrical charge to said charge storage means for storing said electrical charge during a subsequent charge coupling cycle; and

detector means for detecting the end of each charge coupling cycle and initiating the next charge generation cycle.

5. The apparatus of claim 4 wherein said detector means comprises:

means for sensing the level of electrical charge generated during said charge generation cycle;

means for detecting when said electrical charge has been stored by said charge storage means; and

means responsive to said means for detecting for generating a signal indicating the end of the charge coupling cycle when said means for detecting detects that said electrical charge has been stored by said charge storage means.

6. The apparatus of claim 5 including switch means connected in circuit with said charge generation means, said switch means being responsive to said signal generated by said detector means to conduct current through said charge generation means thereby causing said charge generation means to generate said electrical charge during said charge generation cycle, and being responsive to the absence of said signal to prevent current from flowing through said charge generation means thereby causing said charge coupling means to couple the generated electrical charge to said charge storage means during said charge coupling cycle.

7. The apparatus of claim 1 wherein said pulse generator means includes

a plurality of driver means for generating said control signals.

8. The apparatus of claim 7 wherein each of said plurality of driver means is connected to the control means of a pair of said switch means connected in circuit between at least one of said charge storage means and said first sand second output terminals for simultaneously controlling the conduction states of both switch means of said pair to connect and disconnect the potential of said at least one charge storage means across said first and second output terminals.

9. The apparatus of claim 8 wherein:

said plurality of switch means comprises two pairs of switch means;

said plurality of charge storage means comprises a first charge storage means having a first output potential and a second charge storage means having a second output potential;

a first switch means from each pair are connected in a first series connection between said first output potential of said first charge storage means and said second output potential of said second charge storage means;

a second switch means from each pair are connected in a second series connection parallel to the first series connection between said first output potential of said first charge storage means and said second output potential of said second charge storage means;

said first output terminal adapted for connection to a heart comprises the junction of said first series connection between said first switch means from each pair; and

said second output terminal adapted for connection to a heart comprises the junction of said second series connection between said second switch means from each pair.

10. The apparatus of claim 8 including protection means connected to said plurality of driver means disabling every other drive means of said plurality from turning its corresponding pair of switch means to the conductive state when any one of said driver means of said plurality is already enabled to turn its corresponding pair of said switch means to the conductive state.

11. A cardiac defibrillator, comprising:

first and second output terminal means for electrical connection to a heart;

a plurality of charge storage means forming a single multilevel source of waveforms, each storage means storing an electrical charge to provide an output potential;

low voltage power source means;

charging means connected to said plurality of charge storage means and said low voltage power source means for charging said charge storage means;

a plurality of switch means, each having control means operative to render the switch means conductive in response to a control signal, one said switch means of said plurality being connected in circuit between a respective one of each said charge storage means and each of said first and second output terminal means for connecting the potential provided by the said charge storage means to the respective terminal means when said switch means is conductive and disconnecting the potential provided by the said charge storage means from the respective terminal means when said switch means is non-conductive;

pulse generator means connected to said control means of said plurality of switch means for applying control signals to said control means to thereby connect and disconnect said output potentials of said plurality of charge storage means to and from said first and second output terminal means to and from said first and second output terminal means in selected additive and subtractive combinations to generate a multiphasic defibrillation pulse waveform for application to the heart;

means responsive to the onset of cardiac fibrillation for activating said charging means and;

means responsive to the attainment by at least one of said charge storage means of a predetermined level of charge sufficient to defibrillate the heart for activating said pulse generator means.

12. The apparatus of claim 11 wherein said charging means comprises:

charge generation means for generating electrical charge during a charge generation cycle;

charge coupling means for coupling said electrical charge to said charge storage means during a subsequent charge coupling cycle; and

detector means for detecting the end of each charge coupling cycle and initiating the next charge generation cycle.

13. The apparatus of claim 12 wherein said detector means comprises:

means for sensing the level of electrical charge generated during said charge generation cycle;

means for detecting when said electrical charge has been stored by said charge storage means; and

means responsive to said means for detecting for generating a signal indicating the end of the charge coupling cycle when said means for detecting detects that said electrical charge has been stored by said charge storage means.

14. The apparatus of claim 13 including switch means connected in circuit with said charge generation means, said switch means being responsive to said signal generated by said detector means to conduct current through said charge generation means thereby causing said charge generation means to generate said electrical charge during said charge generation cycle, and being responsive to the absence of said signal to prevent current from flowing through said charge generation means thereby causing said charge coupling means to couple the generated electrical charge to said charge storage means during said charge coupling cycle.

15. The defibrillator of claim 11 wherein said pulse generator means includes

a plurality of driver means for generating said control signals.

16. The defibrillator of claim 15 wherein each of said plurality of driver means is connected to the control means of a pair of said switch means connected in circuit between at least one of said charge storage means and said first and second output terminals for simultaneously controlling the conduction states of both switch means of said pair to connect and disconnect the potential of said at least one charge storage means across said first and second output terminals.

17. The defibrillator of claim 16 wherein:

said plurality of switch means comprises two pairs of switch means;

said plurality of charge storage means comprises a first charge storage means having a first output potential and a second charge storage means having a second output potential;

a first switch means from each pair are connected in a first series connection between said first output potential of said first charge storage means and said second output potential of said second charge storage means;

a second switch means from each pair are connected in a second series connection parallel to the first series connection between said first output potential of said first charge storage means and said second output potential of said second charge storage means;

said first output terminal adapted for connection to a heart comprises the junction of said first series connection between said first switch means from each pair; and

said second output terminal adapted for connection to a heart comprises the junction of said second series connection between said second switch means from each pair.

18. The defibrillator of claim 17 including protection means connected to said plurality of driver means and responsive to said control signals for automatically disabling every other driver means of said plurality from turning its corresponding pair of switch means to the conductive state when any one of said driver means of said plurality is already enabled to turn its corresponding pair of switch means to the conductive state.

19. An electrical stimulator apparatus, comprising:

first and second output terminal means for electrical connection to tissue to be stimulated;

a plurality of charge storage means forming a single multilevel source, each said storage means storing an electrical charge to provide an output potential;

low voltage power source means;

charging means connected to said plurality of charge storage means and said low voltage power source means for charging said charge storage means;

a plurality of switch means, each having control means operative to render the switch means conductive in response to a control signal, one switch means of said plurality being connected in circuit between a respective one of said charge storage means and each of said first and second output terminal means for connecting the potential provided by the said charge storage means to the respective terminal means when said switch means is conductive and disconnecting the potential provided by the said charge storage means from the respective terminal means when said switch means is non-conductive;

pulse generator means connected to said control means of said plurality of switch means for applying control signals to said control means to thereby connect and disconnect said output potentials of said plurality of charge storage means to and from said first and second output terminal means in selected additive and subtractive combinations to generate a multiphasic pulse waveform for application to said tissue to be stimulated and

lead means connected between said first and second output terminal means and the tissue to be stimulated.

20. The stimulator apparatus of claim 19, including:

means responsive to a predetermined physiological condition for enabling said charging means to charge said charge storage means; and

means responsive to the attainment by at least one of said charge storage means of a predetermined level of charge for enabling said pulse generator means to generate said multiphasic pulse waveform .

21. A cardiac defibrillator, comprising:

a single source having a plurality of storage means for storing multilevel electrical charges;

means responsive to onset of fibrillation for initiating charging of said storing means;

means for detecting the level of charge stored by said storing means to interrupt said charge upon attainment of a preselected level of stored charge; and

means responsive to attainment of said preselected level for sequentially discharging said storing means with successive alternations of polarity over selected time intervals to generate a multiphasic pulse waveform having at least two successive electrical pulses of predetermined magnitude, duration, and opposite polarity sequence, with energy content sufficient for defibrillation, for delivery to the patient'"'"'s heart.

22. The defibrillator of claim 21, wherein said discharging means includes means for selecting the polarity with which said storing means is first discharged upon attainment of said preselected level, to establish the sequence of alternating polarity of the pulses in said waveform.

23. The defibrillator of claim 21, further including

means for setting said time intervals to establish the duration of each pulse in said waveform.

24. The defibrillator of claim 21, further including

means for setting said preselected level of charge to establish the initial magnitude of the first pulse in said waveform.

25. The defibrillator of claim 24, further including

means for setting said time intervals and the separation thereof, to establish the duration of each pulse, and the initial magnitude of each pulse following the first pulse, in said waveform.

26. The defibrillator of claim 21, wherein said charging means includes means for cyclically delivering packets of electrical charge to said storing means, each packet having a predetermined magnitude, until attainment of said preselected level.

27. The defibrillator of claim 21, further including

conductive lead means for connection at one end thereof to said discharging means and including electrode means at the other end thereof for making electrically stimulating relationship to the patient'"'"'s heart, to deliver said waveform to the heart.

28. The defibrillator of claim 21, wherein

said storing means includes a pair of series-connected high-voltage charge-storing capacitors,

said charging means includes means for cyclically delivering electrical charge in packets, each of predetermined magnitude, to the charge-storing capacitors until said preselected level of charge is attained, and

said discharging means includes means for generating said waveform by sequential discharge of the capacitors to provide the sequence of pulses of successively opposite polarity.

29. The defibrillator of claim 28, wherein

said generating means partially discharges the charge stored on both capacitors in first one polarity and then the opposite polarity.

30. The defibrillator of claim 28, wherein

said generating means partially discharges the charge stored on only one of said capacitors in one polarity and then discharges the charge stored on the other capacitor and the remaining charge stored on said one capacitor in the opposite polarity.