Method and apparatus for assessing myocardial electrical stability
First Claim
1. Method for analyzing cycle-to-cycle variability in a physiologic waveform for assessing relative physiologic stability, comprising:
- digitizing the waveform at a plurality of sample points for each cycle;
constructing two-dimensional sample point matrices, having rows and columns, from the digitized waveform; and
analyzing variability in each column of the sample point matrices to form an index correlating with the physiologic stability.
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Abstract
Myocardial electrical stability is assessed based on the derivation of an alternating ECG morphology index from a series of heartbeats. The ECG electrical signal waveform is digitized at a plurlaity of sample points for each of the series of beats. Sample point matrices from the digitized ECG signals are constructed and the alternating energy at each of the sample points for the series of beats is computed. The alternating energy over the entire set of sample points is summed to generate the total alternating energy. This total alternating energy is normalized with respect to the energy of the average waveform, the normalized value being the alternating ECG morphology index. Animal studies indicate a high negative correlation between cardiac electrical stability and the alternating ECG morphology index.
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Citations
17 Claims
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1. Method for analyzing cycle-to-cycle variability in a physiologic waveform for assessing relative physiologic stability, comprising:
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digitizing the waveform at a plurality of sample points for each cycle; constructing two-dimensional sample point matrices, having rows and columns, from the digitized waveform; and analyzing variability in each column of the sample point matrices to form an index correlating with the physiologic stability. - View Dependent Claims (2, 3, 14)
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4. Apparatus for analyzing cycle-to-cycle variability in a physiologic waveform for assessing relative physiologic stability, comprising:
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means for digitizing the waveform at a plurality of sample points for each cycle; means for constructing sample point matrices, having rows and columns, from the digitized waveform; and means for analyzing variability in each column of the sample point matrices to form an index correlating with the physiologic stability.
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5. Method for deriving an alternating ECG morphology index from a series of heartbeats for assessing relative myocardial electrical stability, comprising:
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digitizing the ECG electrical signal waveform at a plurality of sample points for each of the beats; constructing sample point matrices, having rows and columns, from the digital ECG signal; computing the alternating energy at each of the sample points for the series of beats; summing the alternating energy over the entire set of sample points to generate a total alternating energy; and normalizing the total alternating energy with respect to energy of the average waveform, the normalized value being the alternating ECG morphology index, the index correlating with the myocardial electrical stability. - View Dependent Claims (6, 7, 8, 9)
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10. Method for assessing relative myocardial electrical stability comprising determining the alternating ECG morphology index comprising:
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digitizing the ECG electrical signal waveform at a plurality of sample points for each of the beats; constructing sample point matrices, having rows and columns, from the digital ECG signal; computing the alternating energy at each of the sample points for the series of beats; summing the alternating energy over the entire set of sample points to generate a total alternating energy; normalizing the total alternating energy with respect to energy of the average waveform, the normalized value being the alternating ECG morphology index; and monitoring the changes in the alternating ECG morphology index; increases in this index correlating with lower myocardial electrical stability and vice versa.
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11. Apparatus for deriving an alternating ECG morphology index from a series of heartbeats for assessing relative myocardial electrical stability, comprising:
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analog-to-digital means for digitizing the ECG electrical signal waveform at a plurality of sample points; means for constructing sample point matrices, having rows and columns, from the digitized ECG signals; digital computer means for computing the alternating energy at each of the sample points for the series of beats; computing means for summing the alternating energy over the entire set of sample points to generate a total alternating energy; computing means for calculating energy in an average ECG electrical signal waveform; and computing means for normalizing the total alternating energy with respect to energy of the average waveform, the normalized value being the alternating ECG morphology index, this index correlating with the myocardial electrical stability. - View Dependent Claims (12, 13)
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15. Method for analyzing cycle-to-cycle variability in an ECG for assessing relative myocardial electrical stability, comprising:
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digitizing the waveform at a plurality of sample points for each cycle; constructing two-dimensional sample point matrices, having rows and columns, from the digitzed waveform; and analyzing variability in each column of the sample point matrices to form an index correlating with the myocardial electrical stability.
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16. Method for analyzing cycle-to-cycle variability in a blood pressure waveform for assessing relative stability of the blood pressure waveform, comprising:
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digitizing the waveform at a plurality of sample points for each cycle; constructing two-dimensional sample point matrices, having rows and columns, from the digitized waveform; and analyzing variabilty in each column of the sample point matrices to form an index correlating with the stability of the blood pressure waveform.
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17. Method for analyzing cycle-to-cycle alternation in a physiologic waveform for assessing relative physiologic stability, comprising:
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digitizing the waveform at a plurality of sample points for each cycle; constructing two-dimensional sample point matrices, having rows and columns, from the digitized waveform; and analyzing alternation in each column of the sample point matrices to form an index correlating with the physiologic stability.
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Specification