Controlled release device for an active substance
First Claim
1. A device for the controlled release of one or more active substances into a fluid medium which comprises said substance homogeneously disposed, with or without one or more inert diluents, and contained substantially in the shape of a truncated cone by means of an impermeable wall or coating on the base and side of said truncated cone.
1 Assignment
0 Petitions
Accused Products
Abstract
A device for the controlled release of a substance having useful activity into a fluid medium at a substantially constant rate, said substance contained in a shape which is substantially that of a truncated cone by means of an impermeable wall or coating on the base and side (but not the top) of said truncated cone. Apparatus useful in manufacture when said device is a tablet for administration to a mammal.
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Citations
39 Claims
- 1. A device for the controlled release of one or more active substances into a fluid medium which comprises said substance homogeneously disposed, with or without one or more inert diluents, and contained substantially in the shape of a truncated cone by means of an impermeable wall or coating on the base and side of said truncated cone.
- 11. A bolus for oral administration into the reticulum or rumen of a ruminant mammal, said bolus being retained in said rumen or reticulum and releasing one or more active agents into the environment of said rumen or reticulum at a substantially constant rate over a prolonged period of time, which comprises said active agent or agents homogeneously disposed in a matrix and contained substantially in the shape of one or a plurality of truncated cones by means of an impermeable wall on the base and side of said truncated cone or cones.
- 14. A tablet for oral administration to a mammal which releases a pharmaceutically active substance into the fluid of the gastrointestinal tract if said mammal at a substantially constant rate over an appreciable time interval which comprises said substance homogeneously disposed, with or without one or more pharmaceutically-acceptable diluents, and contained, substantially in the shape of a truncated cone, by means of an impermeable coating or wall on the base and side of said truncated cone.
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33. A single-station or multistation tablet press for use in the manufacture of tablets substantially in the shape of a truncated cone which, at each station, comprises
(a) a conventional, substantially round and flat or convex lower punch; -
(b) a conventional, substantially round die; and (c) a corresponding upper punch having a cavity which is substantially in the shape of a truncated cone. - View Dependent Claims (34, 35, 36)
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37. An apparatus for removing the coating from the smaller diameter end of a fully coated tablet which is substantially in the shape of a first truncated cone, which comprises
(a) a moving, horizontal plate containing a plurality of perforations substantially in the shape of a second equiangular truncated cone of lesser height, having its larger diameter at the top of the plate and no larger than the larger diameter of said first truncated cone, and its smaller diameter at the bottom of the plate and larger than the smaller diameter of said first truncated cone; -
(b) a means for seating said fully coated tablets in said perforations; (c) a stationary support means above said moving plate to hold the seated tablets in place; (d) a stationary grinding means below the plane of said plate spaced so as to remove the coating from the smaller diameter end of said supported tablets; (e) a means of ejecting the finished tablets.
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Specification