Artificial vessel

• US 4,804,381 A
• Filed: 05/19/1987
• Issued: 02/14/1989
• Est. Priority Date: 06/02/1986
• Status: Expired due to Term

• Current Assignee: Sulzer Brothers, Ltd (Sulzer AG)
• Original Assignee: Sulzer Brothers, Ltd (Sulzer AG)
• Inventors: Turina, Marko, Bittmann, Peter
• Primary Examiner(s): Apley, Richard J.
• Assistant Examiner(s): PREBILIC, PAUL B
• Application Number:
  US07/052,243
• Time in Patent Office: 637 Days
• Field of Search: 427/2, 428/304.4, 435/174, 435/180, 435/182, 435/240, 623/1, 623/11, 623/12, 623/66
• US Class Current: 623/1.41
• CPC Class Codes: A61F 2/062 Apparatus for the production of blood vessels made from natural tissue or with layers of living cells prostheses made from natural tissue or living cells A61L27/507
• CPC Class Codes: A61L 27/507 for artificial blood vessels apparatus for applying cells on a blood vessel prosthesis A61F2/062

Abstract

The arterial vessel is made of a microporous membrane having pores which are filled with a permeable gel or which are closed over by a thin porous layer. A monolayer of endothelial cells is provided on the internal surface for exposure to the blood flow and smooth muscle cells are layered on the outer surface for increasing the viability of the live cells on the membrane and to impart elasticity. A support structure formed of a braided construction of monofilaments of inert material can be provided to limit dilation of the vessel.

Claims

1. An artificial vessel comprising

a porous membrane of bio-inert synthetic material having completely open micropores;

a permeable aqueous gel filling said micropores; and

a closed monolayer of endothelial cells on an internal surface of said membrane.

2. An artificial vessel as set forth in claim 1 wherein at least some of said micropores have a diameter between 10 and 50 μ

m.

3. An artificial vessel as set forth in claim 1 which further comprises a layer of smooth elastic fiber-producing muscle cells on an external surface of said membrane.

4. An artificial vessel as set forth in claim 3 wherein said membrane is tubular and which further comprises a support structure about said membrane for limiting dilation of said membrane.

5. An artificial vessel comprising

a porous tubular membrane of bio-inert synthetic material having completely open micropores;

a porous layer on an internal surface of said membrane and having a plurality of pores therein; and

a closed monolayer of endothelial cells on said layer, said pores of said layer having a size approximately equal to one of said endothelial cells.

6. An artificial vessel as set forth in claim 5 wherein at least some of said micropores have a diameter between 10 and 50 μ

m.

7. An artificial vessel as set forth in claim 5 which further comprises a layer of smooth elastic fiber-producing muscle cells on an external surface of said membrane.

8. An artificial vessel as set forth in claim 7 which further comprises a support structure about said membrane for limiting dilation of said membrane.

9. An artificial vessel comprising

a porous membrane of bio-inert synthetic material having completely open micropores;

means for smoothing an internal surface of said membrane while at least partially maintaining the permeability of said membrane;

a closed monolayer of endothelial cells on said internal surface of said membrane; and

a layer of smooth elastic fiber-producing muscle cells on an external surface of said membrane.

10. An artificial vessel comprising

a porous membrane of bio-inert synthetic material made of polyurethane of a thickness of from 0.1 to 1 millimeters and having completely open micropores;

means for smoothing an internal surface of said membrane while at least partially maintaining the permeability of said membrane; and

a closed monolayer of endothelial cells on said internal surface of said membrane.

11. An artificial vessel comprising

a porous membrane of bio-inert synthetic material having completely open micropores;

an aqueous gel filling said micropores and being permeable to molecules of a molecular weight up to 100,000 Dalton to smooth an internal surface of said membrane while at least partially maintaining the permeability of said membrane; and

a closed monolayer of endothelial cells on said internal surface of said membrane.

12. An artificial vessel comprising

a porous membrane of bio-inert synthetic material having completely open micropores;

a porous layer for smoothing an internal surface of said membrane while at least partially maintaining the permeability of said membrane; and

a closed monolayer of endothelial cells on said porous layer with said porous layer having pores of a diameter equal to the dimensions of an endothelial cell.

13. An artificial vessel comprising

a porous tubular membrane of bio-inert synthetic material having completely open micropores;

means for smoothing an internal surface of said membrane while at least partially maintaining the permeability of said membrane;

a closed monolayer of endothelial cells on said internal surface of said membrane, and

a braided support structure about said membrane for limiting dilation of said membrane.

16. An artificial vessel as set forth in claim 13 wherein said support structure consists of a knitted textile having a stitch width of from 0.2 to 2 millimeters.

17. An artificial vessel as set forth in claim 16 wherein said membrane has a linear elasticity of from 0.03 to 0.1% per mm Hg pressure increase at an internal pressure of 80 to 150 mm Hg.

18. An artificial vessel as set forth in claim 16 wherein said braided support structure consists of a braiding of individual spirally arranged filaments of polyester threads of 10 to 40 μ

m diameter.

14. An artificial vessel comprising

a porous membrane of bio-inert synthetic material having completely open micropores, at least some of said micorpores having a diameter between 10 and 50 μ

m;

means for smoothing an internal surface of said membrane while at least partially maintaining the permeability of said membrane; and

a closed monolayer of endothelial cells on said internal surface of said membrane.

15. An artificial vessel as set forth in claim 14 wherein said micropores have a diameter of 30 μ

m.