Artificial vessel

• US 4,804,382 A
• Filed: 05/19/1987
• Issued: 02/14/1989
• Est. Priority Date: 06/02/1986
• Status: Expired due to Term

• Current Assignee: Sulzer Brothers, Ltd (Sulzer AG)
• Original Assignee: Sulzer Brothers, Ltd (Sulzer AG)
• Inventors: Turina, Marko, Bittmann, Peter
• Primary Examiner(s): Apley, Richard J.
• Assistant Examiner(s): PREBILIC, PAUL B
• Application Number:
  US07/051,659
• Time in Patent Office: 637 Days
• Field of Search: 427/2, 428/304.4, 435/174, 435/180, 435/182, 435/240, 623/1, 623/11, 623/12, 623/66
• US Class Current: 623/1.41
• CPC Class Codes: A61F 2/062 Apparatus for the production of blood vessels made from natural tissue or with layers of living cells prostheses made from natural tissue or living cells A61L27/507
• CPC Class Codes: A61L 27/507 for artificial blood vessels apparatus for applying cells on a blood vessel prosthesis A61F2/062

Abstract

The artificial vessel has a membrane of at least semi-permeable bio-inert synthetic material with a monolayer of endothelial cells on the internal surface and a layer of smooth elastic fiber-generating muscle cells on the outer surface. The membrane may be made pore-less or may be made with a network of opened micropores filled with an aqueous gel to provide a smooth internal surface on which the endothelial cells may be coated.

Claims

1. An artificial vessel comprising

a tubular membrane of at least semi-permeable bio-inert synthetic material;

a monolayer of endothelial cells on an internal surface of said membrane for contact with a blood stream; and

a layer of smooth elastic fiber-generating muscle cells on an outer surface of said membrane.

2. An artificial vessel as set forth in claim 1 wherein said membrane is a poreless polymer of polyamino acids and urethane.

3. An artificial vessel as set forth in claim 1 wherein said membrane is a synthetic material with completely open micropores of a diameter between 10 and 50 μ

m.

4. An artificial vessel as set forth in claim 3 wherein said pores have a diameter of 30 μ

m.

5. An artificial vessel as set forth in claim 1 which further comprises a support structure surrounding said membrane to limit dilation of said membrane.

6. An artificial vessel as set forth in claim 5 wherein at an internal pressure of 80 to 150 mm Hg, said membrane has a linear elasticity of 0.03 to 0.1% per mm Hg pressure increase.

7. An artificial vessel as set forth in claim 5 wherein said support structure consists of a textile knitwear having a stitch width between 0.2 and 2 millimeters.

8. An artificial vessel as set forth in claim 7 wherein said support structure consists of braided material of individual spirally arranged filaments of polyester threads of a diameter of 10 to 40 μ

m.

9. An artificial vessael as set forth in claim 1 wherein said membrane has a thickness of from 0.1 to 1 millimeter.

10. An artificial vessel comprising

a membrane of at least semi-permeable bio-inert synthetic material and having a thickness of from 0.1 to 1 millimeter;

a monolayer of endothelial cells on an internal surface of said membrane for contact with a blood stream;

a layer of smooth elastic fiber-generating muscle cells on an outer surface of said membrane; and

a support structure surrounding said membrane to limit dilation of said membrane.

11. An artificial vessel as set forth in claim 10 wherein said support structure consists of braided material of individual spirally arranged filaments of polyester threads of a diameter of 10 to 40 μ

m.