Plasmapheresis system and method

• US 4,806,247 A
• Filed: 07/29/1987
• Issued: 02/21/1989
• Est. Priority Date: 04/12/1985
• Status: Expired due to Term

• Current Assignee: Baxter International Inc.
• Original Assignee: Baxter International Inc.
• Inventors: Hansen, Lee E., Schoendorfer, Donald W.
• Primary Examiner(s): Sever, Frank
• Application Number:
  US07/079,108
• Time in Patent Office: 573 Days
• Field of Search: 210/644, 210/645, 210/646, 210/647, 210/648, 210/649, 210/650, 210/651, 210/652, 210/780, 210/784, 210/195.2, 210/216, 210/217, 210/257.2, 210/297, 210/321.1 , 210/321.2, 210/321.3, 210/359, 210/360.1, 210/433.2, 210/402, 210/416.1
• US Class Current: 210/321.68
• CPC Class Codes: A61M 1/265 inducing Taylor vortices
• CPC Class Codes: A61M 1/30 Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/303 having a reservoir for treated blood to be returned
• CPC Class Codes: A61M 1/308 Volume control, e.g. with open or flexible containers, by counting the number of pump revolutions, weighing
• CPC Class Codes: A61M 1/3496 Plasmapheresis; Leucopheresis; Lymphopheresis A61M1/3472 takes precedence
• CPC Class Codes: A61M 1/3672 Means preventing coagulation
• CPC Class Codes: A61M 1/3693 using separation based on different densities of components, e.g. centrifuging

Abstract

A reliable flow rate plasmapheresis system includes a rotating enhanced vortex type of membrane filter coupled to receive a flow of anticoagulated whole blood and separate concentrate and filtrate in responses thereto. An anticoagulant pump is coupled to mix controlled amounts of anticoagulant with the input blood flow. Degradation of plasma flow rate during multiple extraction-reinfusion cycles is inhibited by selecting the starging anticoagulant pH value and controlling the anticoagulant flow rate relative to the whole blood to establish a final whole blood/plasma pH value in the range of 6.8 to 7.2, with an anticoagulant to blood ratio in the range of 1:6 to 1:25.

Claims

1. A system for separating plasma filtrate from whole blood comprising:

a filter system including a rotating vortex enhanced separator having a filter membrane, the filter system being coupled to receive a flow of anticoagulated whole blood, a source of anticoaguant fluid having a pH value range of 4.4 to 5.5; and

output flows of packed cells and plasma filtrate in response thereto; and

the anticoagulant pump coupled to pump an anticoagulant fluid into the flow of whole blood, the pump including means for operating the pump at a rate controlled to provide anticoagulated whole blood with a pH value in the range of 6.8 to 7.2.

2. A system according to claim 1 wherein the filtrate is plasma.

3. A system according to claim 1 wherein the anticoagulant fluid has a pH in the range of 4.5 to 4.8.

4. A system according to claim 1, wherein the blood is subjected to Taylor vortex action adjacent the filter membrane and including means for maintaining the blood flow rates and plasma extraction rates substantially constant during first and subsequent extraction cycles despite variation in donor blood characteristics.

5. A system for filtration of at least one lighter density component from a whole blood flow passing adjacent a filtration membrane comprising:

a filter membrane;

a source of anticoagulant fluid having a pH value in the range of 4.4 to 5.5;

an anticoagulant pump coupled to mix the anticoagulant fluid with the whole blood;

a blood pump pumping the whole blood with mixed anticoagulant adjacent the filtration membrane for filtering of the lighter density component through the membrane; and

a control system controlling the anticoagulant pump and the blood pump to maintain the proportion of anticoagulant fluid in the range of 1;

6 to 1;

25 relative to the whole blood and the pH of the lighter density component filtered from the whole blood in the range of 6.8 to 7.2.

6. A system according to claim 5 wherein the anticoagulant fluid has a pH in the range of 4.5 to 4.8 and the lighter density component is plasma.

7. A system according to claim 6 wherein the control system passes the whole blood mixed with anticoagulant adjacent the membrane in a plurality of cycles with a dwell interval between each cycle.

8. A system according to claim 7 further comprising a housing disposed in spaced relationship to the membrane with the whole blood mixed with anticoagulant passing therebetween and means for rotating the filter membrane to produce Taylor vortices in the space between the housing and the membrane.